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| 1 | Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells显示文摘AIM:To investigate effects of iron on oxidative stress, heme oxygenase-1(HMOX1)and hepatitis C viral(HCV) expression in human hepatoma cells stably expressing HCV proteins. METHODS:Effects of iron on oxidative stress,HMOX1, and HCV expression were assessed in CON1 cells. Measurements included mRNA by quantitative reverse transcription-polymerase chain reaction,and protein levels by Western blots. RESULTS:Iron,in the form of ferric nitrilotriacetate,increased oxidative stress and up-regulated HMOX1 gene expression.Iron did not affect mRNA or protein levels of Bach1,a repressor of HMOX1.Silencing the up-regulation of HMOX1 nuclear factor-erythroid 2-related factor 2(Nrf2)by Nrf2-siRNA decreased FeNTA-mediated up-regulation of HMOX1 mRNA levels.These iron effects were completely blocked by deferoxamine(DFO).Iron also significantly decreased levels of HCV core mRNA and protein by 80%-90%, nonstructural 5A mRNA by 90%and protein by about 50%in the Con1 full length HCV replicon cells, whereas DFO increased them. CONCLUSION:Excess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells.This probably mitigates liver injury caused by combined iron overload and HCV infection. | Wei-Hong Hou Lisa Rossi Ying Shan Jian-Yu Zheng Richard W Lambrecht Herbert L Bonkovsky | 2009 | World Journal of Gastroenterology2009，15，36： | 5 |
| 2 | Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis显示文摘 | Herbert L Bonkovsky Qaiser Jawaid Kristina Tortorelli Paula LeClair Joseph Cobb Richard W Lambrecht Barbara F Banner | 1999 | Journal of Hepatology1999，，3： | 2 |
| 3 | Optical-absorption bands in the 1-3 eV range in n-type SiC polytypes 显示文摘 | LIMPIJUMNONG S LAMBRECHT W R L RASHKEEV S N | 1998 | Physical Review B1998，57，12： | 1 |
| 4 | Influence of dif- ferent chemical elements on irradiation-induced hardening embrittlement of RPV steels 显示文摘 | Lambrecht M Malerba L Almazouzi A | 2008 | Journal of Nuclear Ma- terials2008，378，3： | 1 |
| 5 | Deep venous throm- bosis in gynecological oncology: incidence and clinical symptoms study 显示文摘 | Santoso J T Evans L Lambrecht L | 2009 | Eur J Obstet Gynecol Reprod Biol2009，144，2： | 1 |
| 6 | Anopheles gambiae immune responses to Sephadex beads:involvement of anti-Plasmodium factors in regulating melanization显示文摘 | Warr E Lambrechts L Koella JC | | 0，，10： | 1 |
| 7 | ltow to simulate wear? Overview of existing methods 显示文摘 | Lambrechts P Debels F Van l anduyt K | | Dent Mater0，22，8： | 1 |
| 8 | Position,shape,and dimension of the maxilla in unoperated cleft lip and palate patients显示文摘 | Lambrecht TH Kreusch TH Schulz L | 2000 | Clin Anat2000，13，： | 1 |
| 9 | Calculated phonon band structure and density of states and interpretation of Raman spec-trum in rocksalt ScN显示文摘 | Paudel Tula R Lambrecht Walter R L | 2009 | Phys Rev B2009，79，85： | 1 |
| 10 | Treatment Of motorneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS 显示文摘 | L Storkebaum D Lambrechts M Dewerchin | 2005 | Nat Neurosci2005，8，： | 1 |
| 11 | Deep venous thrombosisin gynecological oncology: Incidence and clinical symptoms study显示文摘 | Santoso JT Evans L Lambrecht L’ | 2009 | Eur J Obstet Gj^necol Reprod Biol2009，14，6： | 1 |
| 12 | 显示文摘 | Kim K Lambrecht W R L Segall B | 1996 | Phys Rev B1996，53，16： | 1 |
| 13 | Validated sandwich en- zyme-linked immunosorbent assay for casein and its application to retail and milk-allergic complaint foods显示文摘 | HEFLE S L LAMBRECHT D M | 2004 | Journal of Food Protec- tion2004，67，9： | 1 |
| 14 | Elastic constant and related properties of tetrahedrally bonted BN,Ain,GaN and InN显示文摘 | Kimk Lambrecht W R L Segall B | 1996 | Phys Rev B1996，53，16： | 1 |
| 15 | Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects 显示文摘 | Swan S K St Peter J V Lambrecht L J | 2000 | Pharmacotherapy2000，20，7： | 1 |
| 16 | Deep venous thrombosis in gynecological oncology:incidence and clinical symptoms study 显示文摘 | Santoso JT Evans L Lambrecht L | 2009 | European Journal of Obstetrics Gynecology and Reproductive Biology2009，144，2： | 1 |
| 17 | Effects of a self-etching primer on enamel shear bond strengths and SEM morphology显示文摘 | Perdigao J Lopes L Lambrechts P | 1997 | Am J Dent1997，10，： | 1 |
| 18 | Consequences of the expan- ding global distribution of Aedes albopictus for dengue virus trans- mission显示文摘 | Lambrechts L Scott T W Gubler D J | 2010 | PLoS Negl Trop Dis2010，4，5： | 1 |
| 19 | The heterologous expression of polysaccharidase-encoding genes with oenological relevance in Saccharomyces cerevisiae 显示文摘 | van Rensburg P Strauss M L Lambrechts M G | 2007 | J Appl Microbiol2007，103，6： | 1 |
| 20 | Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission 显示文摘 | LAMBRECHTS L SCOTT TW GUBLER DJ | 2010 | PLoS Negl Trop Dis2010，4，5： | 1 |
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