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| 1 | Diabetes epidemic sweeping the Arab world显示文摘The prevalence of type-2 diabetes mellitus(T2DM) has increased dramatically during the last 2 decades, a fact driven by the increased prevalence of obesity, the primary risk factor for T2 DM. The figures for diabetes in the Arab world are particularly startling as the number of people with diabetes is projected to increase by 96.2% by 2035. Genetic risk factors may play a crucial role in this uncontrolled raise in the prevalence of T2 DM in the Middle Eastern region. However, factors such as obesity, rapid urbanization and lack of exercise are other key determinants of this rapid increase in the rate of T2 DM in the Arab world. The unavailability of an effective program to defeat T2 DM has serious consequences on the increasing rise of this disease, where available data indicates an unusually high prevalence of T2 DM in Arabian children less than 18 years old. Living with T2 DM is problematic as well, since T2 DM has become the 5th leading cause of disability, which was ranked 10 th as recently as 1990. Giving the current status of T2 DM in the Arab world, a collaborative international effort is needed for fighting further spread of this disease. | Bisher Abuyassin Ismail Laher | 2016 | World Journal of Diabetes2016，7，8： | 3 |
| 2 | 肌联蛋白titin介导抗阻和有氧运动对糖尿病性心肌舒张功能障碍的不同影响显示文摘目的:比较有氧和抗阻运动对糖尿病性心肌舒张功能障碍的不同影响,探讨titin在抗阻和有氧运动干预糖尿病性心肌舒张功能障碍中的作用。方法:6周龄雄性Sprague-Dawley大鼠60只,随机分为6组:空白对照组(C)、有氧运动对照组(A)、抗阻运动对照组(R)、糖尿病模型组(D)、糖尿病有氧运动干预组(DA)和糖尿病抗阻运动干预组(DR),每组各10只。7周高脂高糖饲料喂养联合1次小剂量链脲佐菌素(streptozotocin,STZ)腹腔注射建立糖尿病大鼠模型;有氧干预采用小动物跑台跑步运动(21 m/min,60 min/天),抗阻干预采用负重爬梯运动(50%、75%、90%最大负重各爬行3次,100%最大负重≤3次,1组/天),每周5天,共训练8周。结果:糖尿病大鼠均表现出明显的空腹血糖(FBG)升高(+336.3%)和左心室舒张末压(LVEDP)增大(+36.1%),左心室内压最大下降速率(Min dp/dt)降低(-26.4%),松弛时间常数(Tau)明显延长(+25.5%),且心肌肌联蛋白titin表达显著下降(-21.7%);抗阻和有氧运动都可明显降低糖尿病大鼠血糖的高水平状态(有氧:-54.3%;抗阻:-66.0%)。有氧运动干预后糖尿病大鼠心肌titin表达明显升高(+15.9%vD,+22.0%vDR),Tau明显缩短(-17.1%vD,-23.3%vDR);抗阻运动干预后糖尿病大鼠心肌titin表达、Min dp/dt和Tau并未出现明显改善。结论:有氧运动对大鼠糖尿病性心肌舒张功能障碍的改善效果明显优于抗阻运动,可能与两种运动方式对心肌肌联蛋白titin表达的不同影响有关。 | 李顺昌 高德润 Ismail Laher 苏全生 | 2021 | 中国体育科技2021，57，11： | 2 |
| 3 | Amniocentesis trainer: development of a cheap and reproducible new training model 显示文摘 | Tassin M Cordier AG Laher G | 2012 | Journal de Gyn~cologie Obstetrique et Biologie de la Reproduction2012，41，7： | 1 |
| 4 | Newfrontiers in obstructive sleep apnoea显示文摘 | Najib T Ayas Allen A J Hirsch Ismail Laher | 2014 | Clinical Science2014，127，4： | 1 |
| 5 | New frontiers in ob- structive sleep apnoea显示文摘 | Ayas N THirsch A A Laher I | 2014 | Clin Sci (Lond)2014，127，4： | 1 |
| 6 | Antioxidants in the treatment of diabetes显示文摘 | Golbidi S Ebadi S A Laher I | 2011 | Curr Diabetes Rev2011，7，2： | 1 |
| 7 | Insulin-induced vasodilation is dependent on tetrahydrobiopterin synthesis显示文摘 | Verma S Arikawa E Yao L Laher I McNeill JH | 1998 | Metabolism1998，47，： | 1 |
| 8 | Updated excitation and ionization cross sections for electron impact on atmoic oxygen/显示文摘 | Laher R Gilmore F | 1990 | Journal of Physical and Chemical Reference Data1990，19，1： | 1 |
| 9 | Exercise, vascular wall andcardiovascular diseases: an update: part 2 显示文摘 | Yung LM Laher I Yao X | 2009 | Sports Med2009，39，： | 1 |
| 10 | Antioxidant and anti-inflammatory effects of exer- cise in diabetic patients 显示文摘 | Golbidi S Badran M Laher I | 2012 | Exp Diabetes Res2012，2012，94： | 1 |
| 11 | Molecular mechanisms of the cardiovascular protective effects of polyphenols显示文摘 | Andriantsitohaina R Auger C Thierry Chataigneau T ltienne-Selloum N Huige Li H Marttnez MC Schini-Kerth VB Laher I | | 0，，： | 1 |
| 12 | Oxidized low-density lipoprotein Inhibits endothelium-dependent vasodilation by an antioxidantsensitive,lysophosphatidylcholine-independent mechanism 显示文摘 | Chan H Lougheed M Laher I | 2003 | Cardiovasc Pharmacol2003，41，6： | 1 |
| 13 | Twenty Years of Calcium Imaging:Cell Physiology To Dye For显示文摘 | Knot HJ Laher I Sobie EA | 2005 | Mol Interview2005，5，2： | 1 |
| 14 | Signaling mechanisms in cerebral vasospasm 显示文摘 | Nishizawa S Laher I | 2005 | Trends Cardiovasc Med2005，15，1： | 1 |
| 15 | Protein kinase C and cerebral vasospasm显示文摘 | Laher I Zhang J H | 2001 | J Cereb Blood Flow Metab2001，21，8： | 1 |
| 16 | Antioxidants in the treatment of diabetes显示文摘 | Golbidi S Alireza Ebadi S Laher I | 2011 | Current Diabetes Reviews2011，7，2： | 1 |
| 17 | Exercise,Vascular Wall and Cardiovascular Diseases显示文摘 | Leung FP Yung LM Laher 1 | 2008 | Sports Medicine2008，38，12： | 1 |
| 18 | Twenty years of calcium imaging: cell physiology to dye for显示文摘 | Knot HJ Laher I Sobie EA | 2005 | Mol Inter2005，5，： | 1 |
| 19 | Bladder dysfunction in diabetes mellitus显示文摘 | Golbidi S Laher I | 2010 | Front Pharmacol2010，1，： | 1 |
| 20 | Insights into obstructive sleep apnea research显示文摘 | Badran M Ayas N Laher I | 2014 | Sleep Med2014，15，5： | 1 |
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