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| 1 | Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa... | YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 42 |
| 2 | Efficacy of epalrestat plus α-lipoic acid combination therapy versus monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials显示文摘OBJECTIVE: To evaluate the efficacy of α-lipoic acid(ALA) plus epalrestat combination therapy in the treatment of diabetic peripheral neuropathy(DPN). DATA SOURCES: The electronic databases of Pub Med, Medline, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, the Wanfang Database and the Chinese Biomedical Database were used to retrieve relevant studies without language restrictions. The search was conducted from the inception of each database to 7 October 2016. The key terms were(diabetic peripheral neuropathy or diabetic neuropathy or DPN) AND(α-lipoic acid or lipoic acid or thioctic acid) AND epalrestat. DATA SELECTION: All of the eligible studies met the following inclusion criteria:(1) Randomized controlled trials that compared efficacy and safety of epalrestat plus ALA combination therapy versus epalrestat or ALA monotherapy in patients with DPN.(2) The minimum duration of treatment was 2 weeks.(3) The DPN patients were diagnosed using the World Health Organization standardized type 2 diabetes mellitus and DPN criteria.(4) Studies contained at least one measure that could reflect the efficacy of the drug and nerve conduction velocities. Studies in which the control group used epalrestat or ALA combined with other drugs were excluded. Statistical analyses were performed using STATA software for meta-analysis. OUTCOME MEASURES: The primary outcomes were the therapeutic efficacy, median motor nerve conduction velocity(MNCV), median sensory nerve conduction velocity(SNCV), peroneal MNCV and peroneal SNCV.RESULTS: Twenty studies with 1894 DPN patients were included, including 864 patients in the ALA plus epalrestat group, 473 in the ALA group and 557 in the epalrestat group. The efficacy of ALA plus epalrestat combination therapy was superior to ALA and epalrestat monotherapies(RR = 1.29, 95% CI: 1.21–1.38; RR = 1.43, 95% CI: 1.34–1.54, respectively). ALA plus epalrestat combination therapy also significantly improved median MNCV(WMD = 5.41, 95% CI: 2.07–8.75), median SNCV(WMD = 5.87, 95% CI: 1.52–10.22), peroneal MNCV(WMD = 5.59, 95% CI: 2.70–8.47) and peroneal SNCV(WMD = 4.57, 95% CI: 2.46–6.68).CONCLUSION: ALA plus epalrestat combination therapy was superior to ALA and epalrestat monotherapies for clinical efficacy and nerve conduction velocities in patients with DPN. | Ming Zhao Jia-Yi Chen Yu-Dong Chu Ya-Bin Zhu Lin Luo Shi-Zhong Bu | 2018 | Neural Regeneration Research2018，13，6： | 18 |
| 3 | Soil mulching can mitigate soil water defi ciency impacts on rainfed maize production in semiarid environments显示文摘Temporally irregular rainfall distribution and inefficient rainwater management create severe constraints on crop production in rainfed semiarid areas. Gravel and plastic film mulching are effective methods for improving agricultural productivity and water utilization. However, the effects of these mulching practices on soil water supply and plant water use associated with crop yield are not well understood. A 3-yr study was conducted to analyze the occurrence and distribution of dry spells in a semiarid region of Northwest China and to evaluate the effects of non-mulching(CK), gravel mulching(GM) and plastic film mulching(FM) on the soil water supply, plant water use and maize(Zea mays L.) grain yield. Rainfall analysis showed that dry spells of ≥5 days occurred frequen tly in each of 3 yr, accounting for 59.9–69.2% of the maize growing periods. T he >15-d dry spells during the jointing stage would expose maize plants to particularly severe water stress. Compared with the CK treatment, both the GM and FM treatments markedly increased soil water storage during the early growing season. In general, the total evapotranspiration(ET) was not significantly different among the three treatments, but the mulched treatments significantly increased the ratio of pre- to post-silking ET, which was closely associated with yield improvement. As a result, the grain yield significantly increased by 17.1, 70.3 and 16.7% for the GM treatment and by 28.3, 87.6 and 38.2% for the FM treatment in 2010, 2011 and 2012, respectively, compared with the CK treatment. It's concluded that both GM and FM are effective strategies for mitigating the impacts of water deficit and improving maize production in semiarid areas. However, FM is more effective than GM. | ZHU Lin LIU Jian-liang LUO Sha-sha BU Ling-duo CHEN Xin-ping LI Shi-qing | 2015 | Journal of Integrative Agriculture2015，14，1： | 13 |
| 4 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 5 | Effect of repaglinide and gliclazide on glycaemic control, early-phase insulin secretion and lipid profiles in newly diagnosed type 2 diabetics显示文摘repaglinide 和 gliclazide 是的背景广泛地在类型 2 diabetes.They 的治疗使用的胰岛素促泌素通过不同机制刺激胰岛素分泌物并且可以从学习是在 glycaemic 控制上评估 repaglinide 或 gliclazide 的效果的在场的不同 aspects.The 有益于病人,胰岛素分泌物,并且类脂化合物在 47 全部的 A 最新诊断了的类型 2 糖尿病 patients.Methods 介绍打 2 个糖尿病病人被使随机化与 repagl 接受4星期的治疗的 | ZHANG Hong BU Ping XIE Yan-hong LUO Juan LEI Min-xiang MO Zhao-hui LIAO Er-yuan | 2011 | Chinese Medical Journal2011，，2： | 10 |
| 6 | Systematic study of human long intergenic non-coding RNAs and their impact on cancer显示文摘The functional impact of several long intergenic non-coding RNAs (lincRNAs) has been characterized in previous studies. However, it is difficult to identify lincRNAs on a large-scale and to ascertain their functions or predict their structures in laboratory experiments because of the diversity, lack of knowledge and specificity of expression of lincRNAs. Furthermore, although there are a few well-characterized examples of lincRNAs associated with cancers, these are just the tip of the iceberg owing to the complexity of cancer. Here, by combining RNA-Seq data from several kinds of human cell lines with chromatin-state maps and human expressed sequence tags, we successfully identified more than 3000 human lincRNAs, most of which were new ones. Subsequently, we predicted the functions of 105 lincRNAs based on a coding-non-coding gene co-expression network. Finally, we propose a genetic mediator and key regulator model to unveil the subtle relationships between lincRNAs and lung cancer. Twelve lincRNAs may be principal players in lung tumorigenesis. The present study combines large-scale identification and functional prediction of human lincRNAs, and is a pioneering work in characterizing cancer-associated lincRNAs by bioinformatics. | SUN Liang LUO HaiTao LIAO Qi BU DeChao ZHAO GuoGuang LIU ChangNing LIU YuanNing ZHAO Yi | 2013 | Science China(Life Sciences)2013，56，4： | 6 |
| 7 | Multi-objective optimization of space station short-term mission planning显示文摘This paper studies the multi-objective optimization of space station short-term mission planning(STMP), which aims to obtain a mission-execution plan satisfying multiple planning demands. The planning needs to allocate the execution time effectively, schedule the on-board astronauts properly, and arrange the devices reasonably. The STMP concept models for problem definitions and descriptions are presented, and then an STMP multi-objective planning model is developed. To optimize the STMP problem, a Non-dominated Sorting Genetic Algorithm II(NSGA-II) is adopted and then improved by incorporating an iterative conflict-repair strategy based on domain knowledge. The proposed approach is demonstrated by using a test case with thirty-five missions, eighteen devices and three astronauts. The results show that the established STMP model is effective, and the improved NSGA-II can successfully obtain the multi-objective optimal plans satisfying all constraints considered. Moreover, through contrast tests on solving the STMP problem, the NSGA-II shows a very competitive performance with respect to the Strength Pareto Evolutionary Algorithm II(SPEA-II) and the Multi-objective Particle Swarm Optimization(MOPSO). | BU HuiJiao ZHANG Jin LUO YaZhong ZHOU JianPing | 2015 | Science China(Technological Sciences)2015，58，12： | 6 |
| 8 | Development of miniature HTSC wide-band filter with open-loop resonators显示文摘The strong electric and magnetic coupled novel HTSC (high temperature superconductor) open-loop microstrip resonators are studied in this report and the traditional structure of open-loop resonators is improved. A miniature wide-band HTSC bandpass filter is developed by the novel structure, which is fabricated on YBCO/LaAlO3/YBCO substrate with dimensions of 14.8×9.6 mm2. This filter is tested at 77 K, and the specifications are that the center frequency is 2230 MHz, the bandwidth is 455 MHz, and the best insertion loss is 0.14 dB in passband. | ZHANG TianLiang YANG Kai NING JunSong BU ShiRong LIU JuanXiu LUO ZhengXiang | 2008 | Chinese Science Bulletin2008，53，9： | 5 |
| 9 | Design of high temperature superconducting contiguous-band diplexer显示文摘A high temperature superconducting (HTS) contiguous-band diplexer was designed and fabricated. The HTS contiguous-band diplexer was made using 2-inch-diameter LaA1O3 wafers coated with epi-taxial thin film YBO on both sides, and was made up of two 4-pole singly-terminated low-pass prototype bandpass channel filters connected in parallel. Its operation frequency was centered at 3.25GHz and 3.75GHz with 500-MHz-wide channels. The HTS diplexer operated at 77 K shows excellent performance. The insertion loss in the pass-band is less than 0.8 dB and the rejection between per channel is greater than 30dB. In comparison with the conventional diplexer, the HTS diplexer offers more than 2dB improvement in insertion loss performance and 3/4 volume reduction. This design concept can be applied to the design of HTS multiplexer and the future HTS ESM channeliser systems. | NING JunSong YANG Kai LUO ZhenXian BU ShiRong ZHANG TianLiang | 2009 | Chinese Science Bulletin2009，54，7： | 5 |
| 10 | Treatment results and prognostic factors of patients undergoing postoperative radiotherapy for laryngeal squamous cell carcinoma显示文摘Postoperative radiotherapy (PRT) is widely advocated for patients with squamous cell carcinomas of the head and neck that are considered to be at high risk of recurrence after surgical resection. The aims of this study were to evaluate the treatment outcomes of PRT for patients with laryngeal carcinoma and to identify the value of several prognostic factors. We reviewed the records of 256 patients treated for laryngeal squamous cell carcinoma between January 1993 and December 2005. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Log-rank test was employed to identify significant prognostic factors for DFS and OS. The Cox proportional hazards model was applied to identify covariates significantly associated with the aforementioned endpoints. Our results showed the 3-, 5-, and 10-year DFS for all patients were 69.9%, 59.5%, and 34.9%, respectively. The 3-, 5-, and 10-year OS rates were 80.8%, 68.6%, and 38.8%, respectively. Significant prognostic factors for both DFS and OS on univariate analysis were grade, primary site, T stage, N stage, overall stage, lymph node metastasis, overall treatment times of radiation, the interval between surgery and radiotherapy, and radiotherapy equipment. Favorable prognostic factors for both DFS and OS on multivariate analysis were lower overall stage, no cervical lymph node metastasis, and using 60Co as radiotherapy equipment. In conclusion, our data suggest that lower overall stage, no cervical lymph node metastasis, and using 60Co as radiotherapy equipment are favorable prognostic factors for DFS and OS and that reducing the overall treatment times of radiation to 6 weeks or less and the interval between surgery and radiotherapy to less than 3 weeks are simple measures to remarkably improve treatment outcome. | Ting Jin Wei-Han Hu Li-Bing Guo Wen-Kuan Chen Qiu-Li Li Hui Lin Xiu-Yu Cai Nan Ge Rui Sun Si-Yi Bu Xin Zhang Meng-Yao Qiu Wei Zhang Su Luo Yi-Xin Zhou | 2011 | Chinese Journal of Cancer2011，30，7： | 5 |
| 11 | Direct generation of watt-level yellow Dy^(3+)-doped fiber laser显示文摘Yellow lasers(∼565–590 nm)are of tremendous interest in biomedicine,astronomy,spectroscopy,and display technology.So far,yellow lasers still have relied heavily on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost yellow laser systems.Here,we address the challenge through demonstrating,for the first time,to the best of our knowledge,watt-level high-power yellow laser generation directly from a compact fiber laser.The yellow fiber laser simply consists of a Dy^(3+)-doped ZBLAN fiber as gain medium,a fiber end-facet mirror with high reflectivity at yellow and a 450-nm diode laser as the pump source.We comprehensively investigated the dependence of the yellow laser performance on the output coupler reflectivity and the gain fiber length and demonstrated that the yellow fiber laser with an output coupler reflectivity of 4% and a gain fiber length of∼1.8 m yields a maximum efficiency of 33.6%.A maximum output power of 1.12 W at 575 nm was achieved at a pump power of 4.20 W.This work demonstrated the power scaling of yellow Dy^(3+)-doped ZBLAN fiber lasers,showing their promise for applications in ophthalmology,astronomical exploration,and high-resolution spectroscopy. | Jinhai Zou Tianran Li Yanbo Dou Jin Li Nan Chen Yikun Bu Zhengqian Luo | 2021 | Photonics Research2021，9，4： | 5 |
| 12 | A comparative study on different regeneration processes of Pt-Sn/γ-Al2O3 catalysts for propane dehydrogenation显示文摘Three different regeneration processes including hydrogen or nitrogen purging and coke-burning treatment were used to restore the Pt-Sn/γ-Al_2O_3 catalysts, through which propane dehydrogenation reaction was performed in a consecutive reaction-regeneration mode. It was found that the catalyst using hydrogen regeneration showed the best stability compared with those regenerated by nitrogen purging and coke-burning treatment, suggesting that hydrogen regeneration is an effective approach for maintaining the performance of Pt-Sn/γ-Al_2O_3 catalysts in propane dehydrogenation reaction. The effect of different regeneration atmospheres on the metal active center and the coke deposition was investigated by XRD,TEM, N_2-physisorption, TPO, TG and Raman technologies, and the results revealed that hydrogen or nitrogen regeneration resulted in little impact on the size and structure of metal active center, retaining the effective Pt Sn phase over the catalyst. Moreover, hydrogen regeneration not only removed the low dense components of the coke, but also altered the property of the residual coke through hydrogenation, leading to a higher mobility of coke, and thus a higher accessibility of the metal active centers. Whereas nitrogen regeneration only removed the low dense components of the coke. Although coke-burning regeneration caused a thorough coke removal, the catalyst subjected to repeated redox exhibited poor stability due to metal agglomeration, phase segregation and the resulting large Pt_3Sn particle and core-shell structure with a Sn-rich surface. | Changyong Sun Junyin Luo Mingjin Cao Ping Zheng Guocheng Li Jiahao Bu Zhou Cao Shihong Chen Xiaowei Xie | 2018 | Journal of Energy Chemistry2018，27，1： | 5 |
| 13 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 14 | Space station short-term mission planning using ontology modelling and time iteration显示文摘This paper studies the problem of the space station short-term mission planning, which aims to allocate the executing time of missions effectively, schedule the corresponding resources reasonably and arrange the time of the astronauts properly. A domain model is developed by using the ontology theory to describe the concepts, constraints and relations of the planning domain formally, abstractly and normatively. A method based on time iteration is adopted to solve the short-term planning problem. Meanwhile, the resolving strategies are proposed to resolve different kinds of conflicts induced by the constraints of power, heat, resource, astronaut and relationship. The proposed approach is evaluated in a test case with fifteen missions, thirteen resources and three astronauts. The results show that the developed domain ontology model is reasonable, and the time iteration method using the proposed resolving strategies can successfully obtain the plan satisfying all considered constraints. | Huijiao Bu Jin Zhang Yazhong Luo | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 4 |
| 15 | Evolutionary annotation of conserved long non-coding RNAs in major mammalian species显示文摘Mammalian genomes contain tens of thousands of long non-coding RNAs(lnc RNAs) that have been implicated in diverse biological processes. However, the lnc RNA transcriptomes of most mammalian species have not been established, limiting the evolutionary annotation of these novel transcripts. Based on RNA sequencing data from six tissues of nine species, we built comprehensive lnc RNA catalogs(4,142–42,558 lnc RNAs) covering the major mammalian species. Compared to protein-coding RNAs, expression of lnc RNAs exhibits striking lineage specificity. Notably, although 30%–99% human lnc RNAs are conserved across different species on DNA locus level, only 20%–27% of these conserved lnc RNA loci are detected to transcription, which represents a stark contrast to the proportion of conserved protein-coding genes(48%–80%). This finding provides a valuable resource for experimental scientists to study the mechanisms of lnc RNAs. Moreover, we constructed lnc RNA expression phylogenetic trees across nine mammals and demonstrated that lnc RNA expression profiles can reliably determine phylogenic placement in a manner similar to their coding counterparts. Our data also reveal that the evolutionary rate of lnc RNA expression varies among tissues and is significantly higher than those for protein-coding genes. To streamline the processes of browsing lnc RNAs and detecting their evolutionary statuses, we integrate all the data produced in this study into a database named Phylo NONCODE(http://gffzz4d3d7636fb124c4fhcupuw6ofn5f56kxp.ffgz.tsg.suse.edu.cn/phylo Noncode). Our work starts to place mammalian lnc RNAs in an evolutionary context and represent a rich resource for comparative and functional analyses of this critical layer of genome. | BU DeChao LUO HaiTao JIAO Fei FANG ShuangSang TAN ChengFu LIU ZhiYong ZHAO Yi | 2015 | Science China(Life Sciences)2015，58，8： | 3 |
| 16 | Study on daily surface evapotranspiration with SEBS in Tibet Autonomous Region显示文摘有卫星数据集的表面土壤水分蒸发蒸腾损失总量(et ) 的评价是在气候变化,灾难在西藏自治区域(tar ) 监视和水蒸汽和精力的发行量的理解的主要题目之一。这研究在1月11日选择卫星图象,在 2010 的4月6日,7月31日和象冬季,春天,夏天和秋天的代表的10月19日分别地,与潜在的土壤水分蒸发蒸腾损失总量(宠物)和从 Penman-Monteith (下午)方法导出的 et 一起基于表面精力平衡系统( SEBS )估计每日的表面 et 的分发。结果如下被获得。(1 ) et 和宠物的季节的分发基本上从东南部分减少到焦油的西北部分。尽管 et 和宠物有类似的空间分布,仍然有一些差别估计极端特别在焦油的中间、东南的部分珍视最大的价值。不管我们采用了什么样的方法, et 和宠物的最大的价值总是出现在夏天,当那在冬季是最小的时,由秋天或春天列在后面。(2 ) 在 et 的评价当模特儿以便更好理解 SEBS 的精确性,我们从从下午方法获得的 SEBS 和 ET 比较了 ET。结果证明从 SEBS 的 ET 能估计实际 et 的变化趋势,但是它稍微总体上低估或过高估计 et 的价值,特别为有厚森林的那些区域。(3 ) 规范的差别植被索引(NDVI ) 的空间分发从东南部分展出一个减少的趋势到显示在 et 和植被索引之间的分布的显著一致性的 tar 的西北部分。当时, et 与在不同季节的 NDVI,最小,平均数,最大的空气温度和阳光持续时间有关断然好否定地在夏天与降水,相对湿度和风有关加速。 | ZHUO Ga LA Ba PUBU Ciren LUO Bu | 2014 | Journal of Geographical Sciences2014，24，1： | 3 |
| 17 | Network for hypersonic UCAV swarms显示文摘Unmanned combat aerial vehicles(UCAVs)that swarm with both autonomous decision-making and cooperative attacking have been regarded as revolutionary elements of modern warfare.In such a swarm,inter-group connectivity must be ensured in a network to maintain a collective consensus.In recent years,academia and industry have made many efforts to achieve common tactical data link systems and commercial drone networks.However,the existing results have difficulty meeting the needs of cooperative autonomous UCAV swarms with both hypersonic mobility and time sensitivity in severe confrontation scenarios.In this article,we conduct an in-depth investigation of the network used for the hypersonic UCAV swarms,which can be considered as a special form of mobile wireless network.Furthermore,faced with specific functional demands,we summarize the main challenges of designing this dedicated network.In addition,a comprehensive survey of potential solutions for the network design is presented.Lastly,we discuss the possible capabilities of the network given the current forefront of technology,as well as remaining challenges and open issues. | Shixun LUO Zhongshan ZHANG Shuai WANG Shuo ZHANG Jibo DAI Xiangyuan BU Jianping AN | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 18 | Satellite dataset analysis of recent vegetation variation in Tibet region显示文摘This research investigates the recent distribution variation trends of vegetation in the Tibet region using Normalized Difference Vegetation Index (NDVI) data from 2000 to 2007. It also discusses the causes of vegetation degradation in typical regions (such as Nagqu) based on climatic conditions, human activity, and other influencing factors. Results show that the areas with the best vegetation cover are in Nyingchi and the southern part of Shannan, followed by Chamdo, the Lhasa area, and the eastern part of Nagqu. Vegetation in various regions exhibits significant seasonal differences. The vegetation status has improved in some parts of the Tibet region in the past few years, while the areas with the most serious degradation are in the middle and southern parts of the Nagqu region. On average, distinct vegetation degradation occurred between 2003 and 2006 in the whole Tibet region but vegetation has been increasing since 2006. The vegetation cover in summer basically determines the annual vegetation status. An increase in precipitation and decrease in wind speed generally corresponds to an increase in vegetation cover. The reverse is also true: a decrease in precipitation and increase in wind speed correspond to the decrease in vegetation cover. NDVI is thus positively related to temperature and precipitation but has a negative relation with wind speed. Increasing temperature and decreasing precipitation have led to the present vegetation degradation in Nagqu, and vegetation in all of these regions has been affected by growth of human population, intensified urbanization, livestock overgrazing leading to the proliferation of noxious plants, extraction of underground minerals and alluvial gold, extensive harvesting of traditional Chinese medicinal plants [e.g., Cordyceps sinensis, Caladium spp., and saffron crocus (Crocus sativus)], and serious rodent and other pest damage. | Zhuo Ga Xirl Li LUO Bu CaiYun Wang | 2011 | Research in Cold and Arid Regions2011，3，5： | 3 |
| 19 | 3.6 W compact all-fiber Pr3+-doped green laser at 521 nm显示文摘Green semiconductor lasers are still undeveloped,so high-power green lasers have heavily relied on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost green laser systems.Here,we report the first Watt-level all-fiber CW Pr3t-doped laser operating directly in the green spectral region,addressing the aforementioned difficulties.The compact all-fiber laser consists of a double-clad Pr3t-doped fluoride fiber,two homemade fiber dichroic mirrors at visible wavelengths,and a 443-nm fiber-pigtailed pump source.Benefitting from>10 MW∕cm2 high damage intensity of our designed fiber dielectric mirror,the green laser can stably deliver 3.62-W of continuous-wave power at∼521 nm with a slope efficiency of 20.9%.To the best of our knowledge,this is the largest output power directly from green fiber lasers,which is one order higher than previously reported.Moreover,these green all-fiber laser designs are optimized by using experiments and numerical simulations.Numerical results are in excellent agreement with our experimental results and show that the optimal gain fiber length,output mirror reflectivity,and doping level should be considered to obtain higher power and efficiency.This work may pave a path toward compact high-power green all-fiber lasers for applications in biomedicine,laser display,underwater detection,and spectroscopy. | Jinhai Zou Jinfen Hong Zhuang Zhao Qingyuan Li Qiujun Ruan Hang Wang Yikun Bu Xianchao Guan Min Zhou Zhiyong Feng Zhengqian Luo | 2022 | Advanced Photonics2022，4，5： | 2 |
| 20 | Caspase-3 expression in metastatic lymph nodes of esophageal squamous cell carcinoma is prognostic of survival显示文摘AIM:To assess whether differential expression of caspase-3 in paired metastatic lymph nodes(LNs)is prognostic of survival in patients with resectable esophageal squamous cell carcinoma(ESCC).METHODS:Capases-3 expression was evaluated immunohistochemically in 122 pairs of primary ESCCs and regional metastatic LNs assembled on tissue microarrays.The impact of caspase-3 expression on survival outcomes was analyzed by the Kaplan-Meier method and Cox proportional hazards regression model.RESULTS:The level of caspase-3 expression was significantly higher in LN metastases than in primary tumors(P<0.001).Caspase-3 expression in the primary tumors was associated with longer median survival(23 mo vs21 mo,P=0.033),whereas higher expression in paired metastatic LNs was associated with shorter median survival(20 mo vs 22 mo,P=0.043).Multivariate analysis showed that both were independent prognostic factors.CONCLUSION:Caspase-3 expression in metastatic LNs may be a potential independent predictor of poorer overall survival in patients with resected ESCC and LN metastasis.Protein expression in metastatic tumors may be a biomarker prognostic of survival. | Xiu-Shen Wang Kong-Jia Luo Amos Ela Bella Shan-Shan Bu Jing Wen Shui-Shen Zhang Yi Hu | 2014 | World Journal of Gastroenterology2014，20，15： | 2 |
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