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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Pharma-cokinetic/pharmacodynamic modeling of pegfilgras-tim in healthy subjects显示文摘 | Roskos LK Lum P Lockbaum P | 2006 | J Clin Pharmaco2006，46，7： | 1 |
| 3 | Method ofdelivery and pregnancy outcomes inAsia:theWHO global survey onmaternal and perinatal health显示文摘 | Lum biganon P Laopa iboon M Gulmezoglu AM | 2010 | The Lancet2010，375，9713： | 1 |
| 4 | Computed tomography an- giography intralurninal filling defect is predictive of internal ca- rotid artery free-floating tlarombus 显示文摘 | Jaberi A Lum C Stefanski P | 2014 | Neuroradiology2014，56，1： | 1 |
| 5 | Quantification of force abnormalities during passive and active-assisted upper-limb reaching movements in post-stroke hemiparesis显示文摘 | Lum P S Burgar C G Kenney D E | 1999 | IEEE Trans on Biomed Eng1999，46，6： | 1 |
| 6 | Integrating XML with relational database using middleware approach显示文摘 | Computer Science and Information Lecture Notes in Computer Science Lum L C Lee S P | 2005 | Malaysian Journal of Computer Science2005，18，2： | 1 |
| 7 | Max-min surrogate-assisted evolutionary algorithm for robust design显示文摘 | Ong Y S Nair P B Lum K Y | 2006 | IEEE Trans on Evolutionary Computation2006，10，4： | 1 |
| 8 | Renal arteries iso tropic, high-spatial-resolution, unenhanced MR angiography with three dimensional radial phase contrast显示文摘 | Francois C J Lum D P Johnson K M | 2011 | Radiology2011，258，1： | 1 |
| 9 | An inward-facing conformation of a putative metal-chelatetype ABC transporter显示文摘 | Pinkett HW Lee AT Lum P Locher KP Rees DC | | 0，，5810： | 1 |
| 10 | AutoCITE : Automa-ted delivery of CI therapy with reduced effort by therapists 显示文摘 | TAUB E LUM P HARDIN P | 2005 | Stroke2005，6，： | 1 |
| 11 | Modeling Vehicle Accidents and Highway Geometric Design Relationships显示文摘 | MIAOU S P LUM H | 1993 | Ac- cident Analysis & Prevention1993，25，6： | 1 |
| 12 | The bimanual lifting rehabilitator: an adaptive machine for therapy of stroke patients 显示文摘 | LUM P S LEHMAN S L | 1995 | IEEE Transactions on Rehabilitation Engineering1995，3，2： | 1 |
| 13 | Identification of the heterogeneous nuclear ribonucleoprotein A2/B1 as the antigen for the gastrointestinal cancer specific monoclonal antibody MG7 显示文摘 | Lee C H Lum J H Cheung B P | 2005 | Proteomics2005，5，4： | 1 |
| 14 | Variations in DNA elucidate molecular networks that cause disease 显示文摘 | Chen Y Q Zhu J Lum P Y | 2008 | Nature2008，452，7186： | 1 |
| 15 | AutoCITE: automateddelivery of CI therapy with reduced effort by therapists显示文摘 | Taub E Lum PS Hardin P | 2012 | Stroke2012，36，6： | 1 |
| 16 | Polymorphism of bovine β-lactoglobulin promoter and differences in the binding affinity of activator protein 2 transcription factor显示文摘 | Lum S L Dovc P Medrano J F | 1997 | J Dairy Sci1997，80，： | 1 |
| 17 | Development of Robots for Rehabilitation Therapy: The Palo Alto VA/Stanford Experience 显示文摘 | Burgar C G Lum P S Shor P C | 2000 | Journal Rehabilitation Research Development2000，37，6： | 1 |
| 18 | Development of robots for rehabilitation therapy:the Palo Alto VA/Stanford experience显示文摘 | Burgar C G Lum S L Shor P C | 2000 | Journal of Rehabilitation Research and Development2000，37，6： | 1 |
| 19 | Polymorphisms of bovine β-lactoglobulin promoter and differences in the binding affinity of activator protein-2 transcription factor显示文摘 | Lum LS Dov (c) P Medrano JF | | 0，，07： | 1 |
| 20 | A telerehabilitation approach to delivery of constraint-induced movement therapy显示文摘 | Lum P S Uswatte G Taub E | 2006 | Journal ??of Rehabilitation Research & Development2006，43，3： | 1 |
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