|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Insights into the regulation of C-repeat binding factors in plant cold signaling显示文摘Cold temperatures, a major abiotic stress,threaten the growth and development of plants, worldwide. To cope with this adverse environmental cue, plants from temperate climates have evolved an array of sophisticated mechanisms to acclimate to cold periods,increasing their ability to tolerate freezing stress. Over the last decade, significant progress has been made in determining the molecular mechanisms underpinning cold acclimation, including following the identification of several pivotal components, including candidates for cold sensors, protein kinases, and transcription factors. With these developments, we have a better understanding of the CBF-dependent cold-signaling pathway. In this review,we summarize recent progress made in elucidating the cold-signaling pathways, especially the C-repeat binding factor-dependent pathway, and describe the regulatory function of the crucial components of plant cold signaling.We also discuss the unsolved questions that should be the focus of future work. | Jingyan Liu Yiting Shi Shuhua Yang | 2018 | Journal of Integrative Plant Biology2018，60，9： | 36 |
| 2 | Development of quantitative methods for detecting climate contributions to boundary shifts in farming-pastoral ecotone of northern China显示文摘易碎的区域上的气候变化的量的效果是对气候变化的回答的地里的一个热话题。以前的研究把品质上记录气候的影响在耕作牧剧交错群落(FPE ) 在边界移动上变化;然而,为检测气候贡献的量的方法仍然保持相对有限。自从 1970,基于气象学的车站的长期的数据和陆地使用的解释, 1970 年代, 1980 年代, 1990 年代和 2000 年代的气候和陆地使用边界被描出。为了检测气候贡献到 FPE 边界,变,我们开发了二个量的方法在东方西方探索气候和陆地使用边界的空间时间的模式(或南方北方)( 渔网方法) 并且横断方向(数字海岸线分析系统, DSAS 方法) 。结果显示重要差别在不同时期期间在不同区域在气候边界,陆地使用边界,以及气候贡献被展出。西北 FPE 有更小的变化,当东北 FPE 有更大的移动时。在更大的 Hinggan 山和内部蒙古的高原的东南穗的西北部分,气候边界的移动是显著地与陆地使用边界有关。在一个东方西方方向的气候贡献从 10.7% ~ 44.4%,并且那些从 4.7% ~ 55.9% 在一个南方北方方向变化了。从 DSAS 的结果的多数与从渔网的那些一致。DSAS 方法为在小规模的精确察觉更精确、合适,而渔网方法简单在大规模很快并且直接进行统计分析。我们的研究将是有用的适应气候变化,以开发生产潜力,以及在北中国保护 FPE 的环境。 | SHI Wenjiao LIU Yiting SHI Xiaoli | 2017 | Journal of Geographical Sciences2017，27，9： | 8 |
| 3 | Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment显示文摘Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of Salmonella in immunocompetent and immunodeficient mice bearing melanoma allografts.Since flagella are key inducers of the host immune response during bacterial infection,flagella were genetically disrupted to analyse their involvement in Salmonella-mediated cancer therapy.The results showed that flagellum-deficient strains failed to induce significant anti-tumor effects,even when more bacteria were administered to offset the difference in invasion efficiency.Flagella mainly activate immune cells via Flagellin/Toll-like receptor 5(TLR5)signalling pathway.Indeed,we showed that exogenous activation of TLR5 signalling by recombinant Flagellin and exogenous expression of TLR5 both enhanced the therapeutic efficacy of flagellum-deficient Salmonella against melanoma.Our study highlighted the therapeutic value of the interaction between Salmonella and the host immune response through Flagellin/TLR5 signalling pathway during Salmonella-mediated cancer therapy,thereby suggesting the potential application of TLR5 agonists in the cancer immune therapy. | Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 4 | 3D printing of high-performance micro-supercapacitors with patterned exfoliated graphene/carbon nanotube/silver nanowire electrodes显示文摘Micro-supercapacitors(MSCs)show great potential as on-chip energy storage devices for portable electronics.The major flaw of thin-film MSCs is their low energy density.To improve the energy density,thicker electrodes are required.However,the fabrication of MSCs with thick electrodes remains a challenge.In this work,a novel 3D printing method is employed to fabricate high-performance MSCs with interdigitated exfoliated graphene(EG)/carbon nanotube(CNT)/silver nanowire(Ag NW)electrodes.The nanowelding of Ag NW junction plays a critical role in the realization of 3D printing.To enhance the electrochemical performances of EG,phosphorus atoms are incorporated into the carbon framework with 1.7 at%.The areal capacitance of the 3D printed MSC is 21.6 mF cm^(-2)at a scan rate of 0.01 V s^(-1).The areal energy density of the MSC ranges from 0.5 to 2μWh cm^(-2)with a maximum power density of 2.5 mW cm^(-2). | LIU Lang LU JunYong LONG XinLin ZHOU Ren LIU YingQuan WU YiTing YAN KangWei | 2021 | Science China(Technological Sciences)2021，64，5： | 4 |
| 5 | Terrain relief periods of loess landforms based on terrain profiles of the Loess Plateau in northern Shaanxi Province,China显示文摘The Loess Plateau is densely covered by numerous types of gullies which represent different soil erosion intensities.Therefore,research on topographic variation features of the loess gullies is of great significance to environmental protection and ecological management.Using a5 m digital elevation model and data from a national geographic database,this paper studies different topographical areas of the Loess Plateau,including Shenmu,Suide,Yanchuan,Ganquan,Yijun,and Chunhua,to derive representative gully terrain profile data of the sampled areas.First,the profile data are standardized in MATLAB and then decomposed using the ensemble empirical mode decomposition method.Then,a significance test is performed on the results;the test confidence is 95% to 99%.The most reliable decomposition component is then used to calculate the relief period and size of the gullies.The results showed that relief periods of the Chunhua,Shenmu,Yijun,Yuanchuan,Ganquan,and Suide gullies are 1110.14 m,1096.85 m,1002.49 m,523.48 m,498.12 m,and 270.83 m,respectively.In terms of gully size,the loess landforms are sorted as loess fragmented tableland,aeolian and dune,loess tableland,loess ridge,loess hill and loess ridge,and loess hill,in descending order.Taken together,the gully terrain features of the sample areas and the results of the study are approximately consistent with the actual terrain profiles.Thus,we conclude that ensemble empirical mode decomposition is a reliable method for the study of the relief and topography of loess gullies. | Jianjun CAO Guoan TANG Xuan FANG Jilong LI Yongjuan LIU Yiting ZHANG Ying ZHU Fayuan LI | 2019 | Frontiers of Earth Science2019，13，2： | 4 |
| 6 | Isolation of Secondary Metabolites with Antimicrobial Activities from Bacillus amyloliquefaciens LWYZ003显示文摘The strain LWYZ003, which can restrain multiple pathogens, was screened from the sediment of the ocean and identified as Bacillus amyloliquefaciens. Large-scale fermentation and modern chromatographic separation technologies(macroporous resin column chromatography, silica gel column chromatography, thin-layer chromatography and high-performance liquid chromatography) were used to separate antimicrobial products from the fermentation broth of marine-derived Bacillus amyloliquefaciens LWYZ003. Bioactive-guided separation was used in the term of seeking antimicrobial products from the secondary metabolites of Bacillus amyloliquefaciens LWYZ003. As a result, two natural products cycloheximide( 1) and trehalose( 2) were obtained. Their structures were elucidated by Fourier transform infrared spectroscopy, high-resolution mass spectrometry, ~1 H and ^(13) C nuclear magnetic resonance analysis. In the cylinder plate method, compound 1 exhibited stronger antimicrobial activities than compound 2 against Micrococcus luteus, and also exhibited wider antimicrobial spectrum than compound 2. In conclusion, isolation of bioactive secondary metabolites from marine Bacillus sp. has enormous potentials in finding suitable antibiotics to inhibit multiple pathogens. | Zhen Liu Yiting Wang Xiaoqiang Jia Wenyu Lu | 2019 | Transactions of Tianjin University2019，25，1： | 3 |
| 7 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 8 | Recent progress in perovskite solar cells:material science显示文摘Perovskite solar cells represent a promising third-generation photovoltaic technology with low fabrication cost and high power conversion efficiency.In light of the rapid development of perovskite materials and devices,a systematic survey on the latest advancements covering a broad range of related work is urgently needed.This review summarizes the recent major advances in the research of perovskite solar cells from a material science perspective.The discussed topics include the devices based on different type of perovskites(organic-inorganic hybrid,all-inorganic,and lead-free perovskite and perovskite quantum dots),the properties of perovskite defects,different type of charge transport materials(organic,polymeric,and inorganic hole transport materials and inorganic and organic electron transport materials),counter electrodes,and interfacial materials used to improve the efficiency and stability of devices.Most discussions focus on the key progresses reported within the recent five years.Meanwhile,the major issues limiting the production of perovskite solar cells and the prospects for the future development of related materials are discussed. | Jiang-Yang Shao Dongmei Li Jiangjian Shi Chuang Ma Yousheng Wang Xiaomin Liu Xianyuan Jiang Mengmeng Hao Luozheng Zhang Chang Liu Yiting Jiang Zhenhan Wang Yu-Wu Zhong Shengzhong(Frank)Liu Yaohua Mai Yongsheng Liu Yixin Zhao Zhijun Ning Lianzhou Wang Baomin Xu Lei Meng Zuqiang Bian Ziyi Ge Xiaowei Zhan Jingbi You Yongfang Li Qingbo Meng | 2023 | Science China Chemistry2023，66，1： | 3 |
| 9 | Artificial Intelligence Rehabilitation Evaluation and Training System for Degeneration of Joint Disease显示文摘Degeneration of joint disease is one of the problems that threaten global public health.Currently,the therapies of the disease are mainly conservative but not very effective.To solve the problem,we need to find effective,convenient and inexpensive therapies.With the rapid development of artificial intelligence,we innovatively propose to combine Traditional Chinese Medicine(TCM)with artificial intelligence to design a rehabilitation assessment system based on TCM Daoyin.Our system consists of four subsystems:the spine movement assessment system,the posture recognition and correction system,the background music recommendation system,and the physiological signal monitoring system.We incorporate several technologies such as keypoint detection,posture estimation,heart rate detection,and deriving respiration from electrocardiogram(ECG)signals.Finally,we integrate the four subsystems into a portable wireless device so that the rehabilitation equipment is well suited for home and community environment.The system can effectively alleviate the problem of an inadequate number of physicians and nurses.At the same time,it can promote our TCM culture as well. | LIU Weichen SHEN Mengqi ZHANG Anda CHENG Yiting ZHANG Wenqiang | 2021 | ZTE Communications2021，19，3： | 2 |
| 10 | Mechanism of micro-wetting of highly hydrophobic coal dust in underground mining and new wetting agent development显示文摘The internal mechanism of the high hydrophobicity of the coal samples from the Pingdingshan mining area was studied through industrial,element,and surface functional group analysis.Laboratory testing and molecular dynamics simulations were employed to study the impact of three types of surfactants on the surface adsorption properties and wettability of highly hydrophobic bituminous coal.The results show that the surface of highly hydrophobic bituminous coal is compact,rich in inorganic minerals,and poorly wettable and that coal molecules are dominated by hydrophobic functional groups of aromatic rings and aliphatic structures.The wetting performance of surfactants as the intermediate carrier to connect coal and water molecules is largely determined by the interaction force between surfactants and coal(Fs-c)and the interaction force between surfactants and water(Fs-w),which effectively improve the wettability of modified coal dust via modifying its surface electrical properties and surface energy.A new type of wetting agent with a dust removal rate of 89%has been developed through discovery of a compound wetting agent solution with optimal wetting and settling performance.This paper provides theoretical and technical support for removing highly hydrophobic bituminous coal dust in underground mining. | Mingzhong Gao Hongmei Li Yun Zhao Yiting Liu Weiqi Zhou Luming Li Jing Xie Jie Deng | 2023 | International Journal of Mining Science and Technology2023，33，1： | 2 |
| 11 | Gas Occurrence and Accumulation Characteristics of Cambrian–Ordovician Shales in the Tarim Basin, Northwest China显示文摘The Tarim Basin is located in northwestern China and is the biggest basin in China with huge oil and gas resources. Especially the Lower to Middle Cambrian and Middle to Upper Ordovician possess the major marine source rocks in the Tarim Basin and have large shale gas resource potential. The Cambrian–Ordovician shales were mainly deposited in basin–slope facies with thicknesses between 30–180 m. For shales buried shallower than 4500 m, there is high organic matter abundance with TOC(total organic carbon) mainly between 1.0% and 6.0%, favorable organic matter of Type I and Type II, and high thermal maturity with RoE as 1.3%–2.75%. The mineral composition of these Cambrian–Ordovician shale samples is mainly quartz and carbonate minerals while the clay minerals content is mostly lower than 30%, because these samples include siliceous and calcareous shale and marlstone. The Cambrian and Ordovician shales are compacted with mean porosity of 4% and 3%, permeability of 0.0003×10^(-3)–0.09×10^(-3) μm^2 and 0.0002×10^(-3)–0.11×10^(-3) μm^2, and density of 2.30 g/m^3 and 2.55 g/m^3, respectively. The pores in the shale samples show good connectivity and are mainly mesopore in size. Different genetic types of pores can be observed such as intercrystal, intergranular, dissolved, organic matter and shrinkage joint. The reservoir bed properties are controlled by mineral composition and diagenesis. The maximum adsorption amount to methane of these shales is 1.15–7.36 cm^3/g, with main affecting factors being organic matter abundance, porosity and thermal maturity. The accumulation characteristics of natural gas within these shales are jointly controlled by sedimentation, diagenesis, hydrocarbon generation conditions, reservoir bed properties and the occurrence process of natural gas. The natural gas underwent short-distance migration and accumulation, in-place accumulation in the early stage, and adjustment and modification in the later stage. Finally, the Yulin(well Y1) and Tazhong(well T1) areas are identified as the targets for shale gas exploration in the Tarim Basin. | LIU Luofu WANG Ying CHEN Yiting SHEN Baojian GAO Xiaoyue | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 12 | Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift显示文摘Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate rocks.The results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate rocks.Firstly,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study area.Secondly,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic strata.From NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic strata.In profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type faults.In plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal direction.Among them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weakest.This fault activity can be divided into four periods:Sinian,Cambrian-Permian,the early Indosinian period and the late Indosinian-Himalayan period,the transtensional strikeslip faults being the products of oblique extensions of pre-existing weak zones in the Xingkai and Emei taphrogenesis,with a particular inheritance in the main faults.(4)Combined with hydrocarbon accumulation factors,it is considered that the epigenetic karstification of the Tongwan and Caledonian unconformities in the northern slope controlled the formation and distribution of carbonate karst reservoirs over a large area,also acting as a good pathway for oil and gas migration.The extensional faults developed at the margin of the NS trending rift,controlling the sag-platform sedimentary pattern in the Dengying Formation of the Sinian.Strike-slip faults in NE,WNW and ENE directions may control the microgeomorphological pattern inside the platform and intensify the differential distribution of grain beach facies.The multi-stage hereditary activity of strike-slip faults not only improved the porosity and permeability of the reservoirs,but also acted as the main channel of oil and gas migration,providing favorable conditions for the development of the current multi-layer gasbearing scenario in the northern slope of the Central Sichuan Basin. | TIAN Xingwang LIU Guangdi LUO Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN Wei YANG Dailin WANG Yunlong SUN Yiting DOU Shuang | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 2 |
| 13 | Fine-tuning inverse metal-support interaction boosts electrochemical transformation of methanol into formaldehyde based on density functional theory显示文摘Different from traditional metal-support heterogenous catalysts,inverse heterogeneous catalysts,in which the surface of metal is decorated by metal oxide,have recently attracted increasing interests owing to the unique interracial effect and electronic structure.However,a deep insight into the effect of metaloxide interaction on the catalytic performance still remains a great challenge.In our work,an inverse hematite/palladium(Fe_(2) O_(3)/Pd) hybrid nanostructure,i.e.,the active Fe_(2) O_(3) ultrathin oxide layers partially covering on the surface of Pd nanoparticles(NPs),exhibited superior electrocatalytic performance towards methanol oxidation reaction(MOR) as compared to the bare Pd NPs based on density functional theory calculation.The charge could transfer from Pd to Fe_(2) O_(3) driven by the built-in potential at the interface of Pd and Fe_(2) O_(3),which favors the downshift of d band center of Pd.With the assistance of interfacial hydroxyl OH*,the cleavage of O—H and C—H in CH_(3) OH could take place much easily with lower barrier ene rgy on Fe_(2) O_(3)/Pd than that on pure Pd via two electrons transferring reaction pathways.Our results highlight that the syne rgy of Pd and Fe_(2) O_(3) at the interface could facilitate the electrochemical transformation of methanol into formaldehyde assisted with interfacial hydroxyl OH*. | Wenjuan Yang Junjun Li Xiaoya Cui Chenhuai Yang Yiting Liu Xianwei Zeng Zhicheng Zhang Qitao Zhang | 2021 | Chinese Chemical Letters2021，32，8： | 2 |
| 14 | Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis显示文摘Protein phosphorylation and dephosphorylation have been reported to play important roles in plant cold responses.In addition,phospho-regulatory feedback is a conserved mechanism for biological processes and stress responses in animals and plants.However,it is less well known that a regulatory feedback loop is formed by the protein kinase and the protein phosphatase in plant responses to cold stress.Here,we report that OPEN STOMATA 1(OST1)and PROTEIN PHOSPHATASE 2C G GROUP 1(PP2CG1)reciprocally regulate the activity during the cold stress response.The interaction of PP2CG1 and OST1 is inhibited by cold stress,which results in the release of OST1 at the cytoplasm and nucleus from suppression by PP2CG1.Interestingly,cold-activated OST1 phosphorylates PP2CG1 to suppress its phosphatase activity,thereby amplifying cold signaling in plants.Mutations of PP2CG1 and its homolog PP2CG2 enhance freezing tolerance,whereas overexpression of PP2CG1 decreases freezing tolerance.Moreover,PP2CG1 negatively regulates protein levels of C-REPEAT BINDING FACTORs(CBFs)under cold stress.Our results uncover a phosphor/dephosphor-regulatory feedback loop mediated by PP2CG1 phosphatase and OST1 protein kinase in plant cold responses. | Jian Lv Jingyan Liu Yuhang Ming Yiting Shi Chunpeng Song Zhizhong Gong Shuhua Yang Yanglin Ding | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 15 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 16 | Eight emitters clogging characteristics and its suitability evaluation under on-site reclaimed water drip irrigation显示文摘 | Pei Yiting Li Yunkai Liu Yaoze | 2014 | Irrigation Science2014，32，2： | 1 |
| 17 | OPTIMIZATION OF FERMENTATION CONDITIONS AND PURIFICATION OF CORDYCEPIN FROM Cordyceps militaris显示文摘 | Tang Jiapeng Liu Yiting Zhu Li | 2014 | Preparative Biochemistry and Biotechnology2014，，1： | 1 |
| 18 | Comparisons of mouse mesenchymal stem cells in primary adherent culture of compact bone fragments and whole bone marrow 显示文摘 | CAI Yiting LIU Tianshu FANG Fang | 2015 | Stem Cells Int2015，2015，70： | 1 |
| 19 | Enhanced N_(2)-to-NH_(3)conversion efficiency on Cu3P nanoribbon electrocatalyst显示文摘Ambient electroreduction of nitrogen(N_(2))is considered as a green and feasible approach for ammonia(NH_(3))synthesis,which urgently demands for efficient electrocatalyst.Morphology has close relationship with catalytic activity of heterogeneous catalysts.Nanoribbon is attractive nanostructure,which possesses the flexibility of one-dimensional nanomaterials,the large surface area of two-dimensional nanomaterials,and lateral size confinement effects.In this work,Cu_(3)P nanoribbon is proposed as a highly efficient electrocatalyst for N_(2)-to-NH_(3)conversion under benign conditions.When measured in N_(2)-saturated 0.1 M HCl,such Cu_(3)P nanoribbon achieves high performance with an excellent Faradaic efficiency as high as 37.8%and a large yield of 18.9μg·h^(−1)·mgcat.−1 at−0.2 V.It also demonstrates outstanding stability in long-term electrolysis test at least for 45 h. | Qian Liu Yiting Lin Shuang Gu Ziqiang Cheng Lisi Xie Shengjun Sun Longcheng Zhang Yongsong Luo Abdulmohsen Ali Alshehri Mohamed SHamdy Qingquan Kong Jiahong Wang Xuping Sun | 2022 | Nano Research2022，15，8： | 1 |
| 20 | Zinc-substituted hemoglobin with specific drug binding sites and fatty acid resistance ability for enhanced photodynamic therapy显示文摘Precisely designed protein-based nanodrugs, as a kind of colloidal drug system, have attracted significant attention in tumor therapy because of their refined drug loading ratio, controlled delivery efficacy and natural biocompatibility. However, most drugs are conjugated to the protein carriers randomly without specific binding sites. Moreover, such sites could easily be replaced by lipophilic molecules in the physiological environment and result in low delivery efficiency. With strong and specific binding locations especially comparatively narrow spatial binding sites and nonflexible structure, hemin (FePPIX)-free hemoglobin or apohemoglobin (apoHb), as a natural metalloporphyrin protein carrier, represents great potential in bioapplication. Therefore, we herein introduce a folate acid (FA) modified, zinc-substituted hemoglobin (ZnPHb-FA) as a naturally occurring protein matrix-based photosensitizer for cancer photodynamic therapy (PDT). Noncovalent inserted ZnPPIX molecules in apoHb possess an extremely stable property and significant recovered photoproperties with superior biocompatibility and phototoxicity, both in vitro and in vivo. This stability was verified by molecular docking analysis and calculation of binding constant, representing a total of five drug binding sites of apoHb for ZnPPIX molecules, four of which are energetically favorable (△G value of -11.9 kcal/mol), and one which is energetically acceptable (△G value of -9 kcal/mol). Folate acid modification has been shown to efficiently enhance the internalization and retention time of ZnPHb nanodrug. ZnPHb-FA is also an efficient depressor of hemin oxygenase-1 (HO-1), which could, in turn, lower the antioxidant ability of cancer cells by decreasing the production of biiirublin. Results in vitro and in vivo both indicated that the firmly combination of apoHb and ZnPPIX described here represents a novel and efficient protein nanodrug systems for cancer therapy. | Yiting Xu Jiamei Xu Xiaoxiao Hu Xin Xia Qian Dong Zhangkun Liu Zhuo Chen Weihong Tan | 2019 | Nano Research2019，12，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员