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| 1 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Mass vaccination campaign with a two - dose oral cholera vaccine in a refugee camp显示文摘 | Legros D Paquet C Perea W | 1999 | Bull of WHO1999，77，10： | 1 |
| 4 | A patient's guide: polycystic ovary syndrome(PCOS)显示文摘 | Hoeger K M Legro R S Welt C K | 2014 | J Clin Endocrinol Metab2014，99，1： | 1 |
| 5 | Letrozole, gonadotropin, or clomiphene for unexplained infertility 显示文摘 | Diamond MP Legro RS Coutifaris C etal | 2015 | N EnglJ Med2015，373，13： | 1 |
| 6 | Iron-catalyzed Reactions in Organic Synthesis显示文摘 | Bolm C Legros J Paih J L | 2004 | Chem Rev2004，104，12： | 1 |
| 7 | Iron-Catalyzed Reactions in Organic Synthesis显示文摘 | Bolm C Legros J Paiti J L | 2004 | Chem Rev2004，104，： | 1 |
| 8 | Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective , controlled study in 254 affected women显示文摘 | Legro R L Kumselman A R Dodson W C | 1999 | J Clin Endocrinol Metab1999，84，： | 1 |
| 9 | Applications of cata- lytic asymmetric sulfide oxidations to the syntheses of bi- ologically active sulfoxides显示文摘 | LEGROS J DEHLI J R BOLM C | 2005 | Adv Synth Catal2005，347，1： | 1 |
| 10 | Iron-catalyzed reactions in organic synthesis显示文摘 | Bolm C Legros J Paih J L | | 0，，： | 1 |
| 11 | Iron-catalyzed reaction in organic synthe- sis显示文摘 | Bolm C Legros J Paih J | 2004 | Chemical Reviews2004，104，12： | 1 |
| 12 | Evidence for a new class of scorpion toxins active against K+ channels显示文摘 | Legros C Ceard B Bougis PE | 1998 | FEBS Lett1998，431，3： | 1 |
| 13 | Effects of antiepileptic drugs on sleep ar- chitecture: a pilot study显示文摘 | Legros B Bazil C W | 2003 | Sleep Med2003，4，1： | 1 |
| 14 | How Does Calcium-Dependent Intracellular Regulation of Voltage-dependent Sodium Current Increase the Sensitivity to the Oxadiazine Insecticide Indoxacarb Metabolite DecarbomethoxylatedJW062 (DCJW) in Insect Pacemaker Neurons显示文摘 | LAVIALLE-DEFAIX C MOIGNOT B LEGROS C | 2010 | J Pharmacol Exp Ther2010，333，1： | 1 |
| 15 | Fabrication of pure YBaCuO powders with controlled microstructure显示文摘 | C Legros C Haut L Ponsonnet-Mora and J Ayache | 1999 | Journal of the European Ceramic Society1999，19，： | 1 |
| 16 | Scandinavian Journal of Clinical&Laboratory Investigation显示文摘 | Pequeux C Hendrick J C Hagelstein M T Geenen V Legros J J | 2001 | 61(5):4072001，61，5： | 1 |
| 17 | Cancer Research显示文摘 | Pequeux C Breton C Hendrick J C Hagelstein M T Martens H Winkler R Geenen V Legros J J | 2002 | 62(16):46232002，62，16： | 1 |
| 18 | Iron-catalyzed reactions in organic synthesis显示文摘 | BOLM C LEGROS J PAIH J L | 2004 | Chemical Reviews2004，104，12： | 1 |
| 19 | Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women显示文摘 | LEGRO R S KUNSELMAN A R DODSON W C | 1999 | J Clin Endocrinol Metab1999，84，1： | 1 |
| 20 | Iron-catalyzed reactions in organic synthesis 显示文摘 | Bolm C Legros J Paih J L | 2004 | Chem Rev2004，104，： | 1 |
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