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| 1 | 内源乙烯与1-MCP互作对番茄成熟和细胞壁物质代谢的影响显示文摘【目的】探讨内源乙烯与1-MCP的相互作用对贮藏过程中番茄成熟和细胞壁代谢的影响。【方法】将破色期番茄('佛罗里达47')果实分为4组,其中2组经低压低氧(8kPa,1.7kPaO2)处理6h后,分别立即使用50μg/L液态1-MCP(HH+1-MCP)或去离子水(HH)浸泡1min;另外2组未经HH处理的番茄果实,也分别使用50μg/L1-MCP(1-MCP)或去离子水(对照)浸泡1min,测定处理后果实在贮藏(20℃)过程中成熟相关生理指标及细胞壁组分的变化。【结果】番茄果实经HH处理后,内源乙烯含量(IEC)急剧降低至对照水平的75.6%,且对1-MCP的反应敏感性有所提高。HH+1-MCP处理显著抑制了果实硬度的下降,其硬度值在贮藏第4~16天中,平均分别较对照和1-MCP处理高29.8%和15.6%;HH+1-MCP处理果实的呼吸和乙烯峰出现时间均较对照推迟4d,较1-MCP处理推迟2d,但对峰值影响未达到显著水平;与1-MCP处理相比,HH+1-MCP处理对多聚半乳糖醛酸酶(PG)、果胶甲脂酶(PME)、α-半乳糖苷酶(α-Gal)、β-半乳糖苷酶(β-Gal)等细胞壁降解酶活性的变化影响较大,对PG的影响尤为明显;HH+1-MCP处理还显著地抑制了番茄果实贮藏期水溶性和CDTA溶性糖醛酸(UA)含量的增加,其水溶性UA含量在贮藏的第6~12天平均值分别较对照和1-MCP处理低37.3%和21.9%,其CDTA溶性UA含量在贮藏的第6~12天平均值分别较1-MCP处理果实低31.4%和20.5%;凝胶渗透色谱分析结果显示,1-MCP和HH+1-MCP处理延缓了番茄果实多聚糖醛酸分子的降解过程,且后者效果更为明显。此外,本试验HH处理各项测定指标与对照无显著差异。【结论】内源乙烯含量是调节1-MCP反应能力的重要因素,解释了不同跃变型果实在成熟起始后对1-MCP反应敏感性差异的原因。 | 张正科 HUBER Donald J LEE James H 饶景萍 | 2010 | 西北农林科技大学学报(自然科学版)2010，38，11： | 5 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 4 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
| 5 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
| 6 | Human papillomavirus type 16 E6 activates NF-kappaB, induces elAP-2 expression, and protects against apoptosis in a PDZ binding motif-depend ent manner显示文摘 | James M A Lee J H Klingelhutz A J | 2006 | J Virol2006，80，： | 1 |
| 7 | The fore- casting of international expo tourism using quantitative and qualitative techniques 显示文摘 | LEE C K A SONG H J B JAMES M W C | 2008 | Tourism Management2008，，6： | 1 |
| 8 | Glucoamylases:Microbial sources,industrial applications and molecular biology:A review显示文摘 | JAMES J A LEE B H | 1997 | Food Biochemistry1997，21，： | 1 |
| 9 | Gear fatigue crack prognosis using embelded model,gear dynamic model and fracture mechanics显示文摘 | JAMES C LEE H | 2005 | Mechanical Systems and Signal Processing2005，19，2： | 1 |
| 10 | Estimating size of gear tooth root crack using embedded modeling显示文摘 | James Li C Lee H Choi S H | 2002 | Mechanical System Signal Processing2002，16，5： | 1 |
| 11 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
| 12 | Constrained linear state estimation-a moving horizon approach 显示文摘 | CHRISTOPHER V RAO JAMES B RAWLINGS JAY H LEE | 2000 | Automatica2000，37，10： | 1 |
| 13 | Vibration stabilization of a phase shifting interferometer for large optics显示文摘 | COLE G C JAMES H B LEE R D | 1997 | SPIE1997，3134，： | 1 |
| 14 | In - plane Permeability Measurement and Analysis in Liquid Composite Molding显示文摘 | T James Wang C H Wu and L James Lee | 1994 | Polymer Composites1994，15，4： | 1 |
| 15 | ORA Lassila the semantic Web显示文摘 | Berners- Lee T James H | 2001 | Scientific Amcrican2001，，5： | 1 |
| 16 | In-plane Permeability Measurement and Analysys in Liquid Composite Molding显示文摘 | T James Wang C H Wu and L James Lee | 1994 | Polymer Composites1994，15，4： | 1 |
| 17 | Modeling of crack initiation and growth in solid rocket propellants using micromechanics and micromechanics theories显示文摘 | | 1996 | AD-A3195211996，，： | 1 |
| 18 | Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatographyelectrospray tandem mass spectrometry 显示文摘 | James I Lee Bih H Hsu Di Wu | 2006 | J Chromatogr A2006，1116，： | 1 |
| 19 | Cadmium zinc telluride and its use as a nuclear radiation detector material 显示文摘 | SCHLESINGER T E TONEY J E YOON H LEE E Y BRUNETT B A FRANKS L JAMES R B | 2001 | Mater Sci and Eng2001，32，： | 1 |
| 20 | Management and long-term follow-up of hepatic cysts显示文摘 | Matthew F Hansman John A Ryan James H Holmes Stephen Hogan Faye T Lee Donna Kramer Thomas Biehl | 2001 | The American Journal of Surgery2001，，5： | 1 |
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