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| 1 | Factors affecting the performance of a low-pressure submrane photocatalytic reactor显示文摘 | Chin S S L im T M Chiang K | 2007 | Chem Eng J2007，130，1： | 1 |
| 2 | Development of a plate technique for screening of polysaccharide-degrading microorganisms by using a mixture of insoluble chromogenic substrates 显示文摘 | Ten L N Im W T Kim M K | 2004 | Microbiological Methods2004，56，： | 1 |
| 3 | Biological activities of lipoteichoic acid and peptidoglycan - teichoic acid of Bacillus subtilis 168 (Marburg)显示文摘 | L Pyhala RM Olander O Merimskaya T Kuzina O Lysyuk A Pronin A Sanin IM Helander and M Sarvas | 1993 | J Gen Microbiol1993，139，11： | 1 |
| 4 | Production of alpha-1, 3-galactosyltransferase knockout pigs by nuclear transfer cloning显示文摘 | Lai L Kolber-Simonds D Park K W Cheong H T Greenstein J L Im G S Samuel M Bonk A Rieke A DayB N Murphy C N Carter D B Hawley R J Prather R S | 2002 | Science2002，295，5557： | 1 |
| 5 | Synthesis and dispersion characteristics of muhiwalled carbon nanotube composites with poly (methylmethacrylate) prepared by in situ bulk polym erization 显示文摘 | Park S J C ho M S L im S T | 2003 | Maeromoleeular Rapid Communications2003，24，18： | 1 |
| 6 | Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results显示文摘AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) infection.METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic regression.RESULTS SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs. | Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch | 2017 | World Journal of Virology2017，6，4： | 1 |
| 7 | Insulin resistanceand endocrine characteristics of the different phenotypesof polycystic ovary syndrom e: a prospective study显示文摘 | D im itrios P K onstantinos T G eorgios M e ta l | | H um an R eproduction0，27，： | 1 |
| 8 | Development of a plate technique for screening of polysaccharide-degrading microorganisms by using a mixture of insoluble chromogenic substrates 显示文摘 | TEN L N IM W T KIM M K | 2004 | Journal of Microbiological Methods2004，56，： | 1 |
| 9 | Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response 显示文摘 | Rice GI Bond J Asipu A Brunette RL Manfield IW Carr IM Fuller JC Jackson RM Lamb T Briggs TA Ali M GomaU H Couthard LR Aeby A Attard-Montalto SP Bertini E Bodemer C Brockmann K Bmeton LA Corry PC Desguerre I Fazzi E Cazorla AG Gener B Hamel BCJ Heiberg A Hunter M van der Knaap MS Kumar R Lagae L Landrieu PG Lourenco CM Marom D McDermott MF van der Merwe W Orcesi S PrendiviUe JS Rasmussen M Shalev SA Soler DM Shinawi M Spiegel R Tan TY Vanderver A Wakeling EL Wassmer E Whittaker E Lebon P Stetson DB Bonthron DT Crow YJ 2009 | 2009 | Nat Genet2009，41，7： | 1 |
| 10 | Measurement of H2O2 within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix显示文摘 | COCHEME HM QUIN C MCQUAKER S J CABREIRO F LOGAN A PRIME T A ABAKUMOVA I PATEL J V FEARNLEY IM JAMES A M PORTEOUS C M SMITH ROBIN A J SAEED S CARRE J E SINGER M GEMS D ttARTLEY R C PAR- TRIDGE L MURPHY M P | 2011 | Cell Metabolism2011，13，： | 1 |
| 11 | 肾脏叶酸受体1基因变异导致自发性高血压大鼠发生代谢综合征显示文摘同型半胱氨酸以及其他含硫氨基酸代谢与叶酸代谢密切相关。该研究在自发性高血压大鼠(spontaneously hypertensiverats,SHR)与棕色挪威大鼠的重组近交系BXH/HXB中分析叶酸及含硫氨基酸在代谢综合征发展中的可能作用。方法:在含有调节肾脏叶酸受体1mRNA水平的顺式作用表达数量性状基因座的1号染色体区绘制半胱氨酸浓度的数量性状基因座。 | Pravenec M Kozich V Krijt J Sokolová J Zídek V Landa V Mlejnek P ilhavy J imáková M kop V Trnovská J Kazdová L Kajiya T Wang J Kurtz TW 赵狄 练桂丽 | 2015 | 中华高血压杂志2015，23，11： | 0 |
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