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| 1 | Association between endotoxemia and histological features of nonalcoholic fatty liver disease显示文摘AIM To assess whether surrogate biomarkers of endotoxemia were correlated with the histological features ofnonalcoholic fatty liver disease(NAFLD).METHODS One hundred twenty-six NAFLD patients who had undergone percutaneous liver biopsy were enrolled. Serum lipopolysaccharide(LPS)-binding protein(LBP) and anti-endotoxin core immunoglobulin G(Endo Cab Ig G) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological scores. RESULTS Serum LBP concentration was significantly increased in nonalcoholic steatohepatitis(NASH) patients as compared with nonalcoholic fatty liver(NAFL) subjects and was correlated with steatosis(r = 0.38, P < 0.0001) and ballooning scores(r = 0.23, P = 0.01), but not with the severity of lobular inflammation or fibrosis. Multivariate linear regression analysis revealed that LBP was associated with steatosis score and circulating C-reactive protein, aspartate aminotransferase, and fibrinogen levels. Serum Endo Cab Ig G concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between Endo Cab Ig G and histological findings. CONCLUSION LBP/Endo Cab Ig G were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH. | Hiroyuki Kitabatake Naoki Tanaka Naoyuki Fujimori Michiharu Komatsu Ayaka Okubo Kyogo Kakegawa Takefumi Kimura Ayumi Sugiura Tomoo Yamazaki Soichiro Shibata Yuki Ichikawa Satoru Joshita Takeji Umemura Akihiro Matsumoto Masayoshi Koinuma Kenji Sano Toshifumi Aoyama Eiji Tanaka | 2017 | World Journal of Gastroenterology2017，23，4： | 5 |
| 2 | Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms显示文摘瞄准:评估 Ganoderma 的一篇摘录的安全和功效易懂嗯那出现最强壮 5 α-reductase 在由一个双窗帘的 19 朵可食、药用的蘑菇的摘录之中的禁止的活动,控制安慰剂,使随机化并且在有更低的尿道症状(LUTS ) 的人的变化剂量的学习。方法:在这试用,我们随机分配了与 G 有 slight-to-moderate LUTS 到 12 星期处理的超过 49 年岁的 88 个人。易懂嗯摘录(6 mg 一次一天) 或安慰剂。主要结果措施是在国际前列腺症状分数(IPSS ) 和 uroflowmetry 的变量的变化。第二等的结果措施在前列腺尺寸包括了变化,剩余在 voiding,实验室价值和报导不利效果以后的尿体积。结果: G。易懂嗯对为改进全部的 IPSS, 2.1 个点在处理的目的减少的安慰剂有效、显著地优异(吝啬的差别, −1.18 点;95% 信心间隔, −1.74 到 −0.62;P <
0.0001 ) 。没有变化关于生活分数的质量被观察,山峰尿流动,吝啬的尿流动,剩余尿,前列腺体积,浆液前列腺特定的抗原或睾丸激素层次。全面处理很好没有严重不利效果被容忍。结论:G 的摘录。易懂嗯很好被容忍并且改进了 IPSS 分数。这些结果用 G 的摘录为长持续时间鼓励了植物治疗法的进一步的、大规模评估。易懂嗯在有 LUTS 的人上。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，5： | 2 |
| 3 | Expression of theMAGE gene family in human lymphocytic leukemia显示文摘 | Shigeki Shichijio Rika Tsunosue Kazuhiro Masuoka Hideyo Natori Makoto Tamai Jiro Miyajima Kimitaka Sagawa Kyogo Itoh | 1995 | Cancer Immunology Immunotherapy1995，，2： | 1 |
| 4 | Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine显示文摘 | Masanori Noguchi Tetsuro Sasada Kyogo Itoh | 2013 | Cancer Immunology, Immunotherapy2013，，5： | 1 |
| 5 | Lymphokine production by human melanoma tumor-infiltrating lymphocytes显示文摘 | Marie A. Salmeron Tatsuo Morita Hidetoshi Seki Chris D. Platsoucas Kyogo Itoh | 1992 | Cancer Immunology Immunotherapy1992，，3： | 1 |
| 6 | Immunological evaluation of personalized peptide vaccination for patientswith pancreatic cancer显示文摘 | Koutaro Yamamoto Takashi Mine Kazuko Katagiri Nobuaki Suzuki Toru Kawaoka Tomio Ueno Satoko Matsueda Akira Yamada Kyogo Itoh Hideaki Yamana Masaaki Oka | 2005 | Oncology Reports2005，，5： | 1 |
| 7 | Expression of theMAGE gene family in human lymphocytic leukemia显示文摘 | Shigeki Shichijio Rika Tsunosue Kazuhiro Masuoka Hideyo Natori Makoto Tamai Jiro Miyajima Kimitaka Sagawa Kyogo Itoh | 1995 | Cancer Immunology Immunotherapy1995，，2： | 1 |
| 8 | Personalized Peptide Vaccine for Treatment of Advanced Cancer显示文摘 | Tetsuro Sasada Akira Yamada Masanori Noguchi Kyogo Itoh | 2014 | Current Medicinal Chemistry2014，，： | 1 |
| 9 | Increase in the ability of human cancer cells to induce cytotoxic T lymphocytes by ultraviolet irradiation显示文摘 | Yasuiki Umezu Lazel B Augustus Dai Seito Kazuhiro Hayakawa Merric I Ross Omar Eton David A Swanson Kyogo Itoh | 1993 | Cancer Immunology Immunotherapy1993，，6： | 1 |
| 10 | Protein-bound polysaccharide K induced apoptosis of the human Burkitt lymphoma cell line, Namalwa显示文摘 | Takako Saisho Hattori Nobukazu Komatsu Shigeki Shichijo Kyogo Itoh | 2004 | Biomedicine & Pharmacotherapy2004，，4： | 1 |
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