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| 1 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 2 | Down-regulation of tyrosinase,TRP-1,TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma显示文摘Objective:To investigate the suitability of citrus-press cakes,by-products of the juice industry as a source for the whitening agents for cosmetic industry.Methods:Ethylacetate extracts of citrus-press cakes(CCE)were examined for their anti-melanogenic potentials in terms of the inhibition of melanin production and mechanisim of melanogenesis by using Western Blot analysis with tyrosinese,tyrosinase-related protein-1(TRP-1),TRP2,and microphthalmia-associated transcription factor(MITF)proteins.To apply the topical agents,citrus-press cakes was investigated the safety in human skin cell line.Finally flavonoid analysis of CCE was also determined by HPLC analysis.Results:Results indicated that CCE were shown to down-regulate melanin content in a dose-dependent pattern.The CCE inhibited tyrosinase,TRP-2,and MITF expressions in a dose-dependent manner.To test the applicability of CCE to human skin,we used MTT assay to assess the cytotoxic effects of CCE on human keratinocyte HaCaT cells.The CCE exhibited low cytotoxicity at 50μg/mL.Characterization of the citrus-press cakes for flavonoid contents using HPLC showed varied quantity of rutin,narirutin,and hesperidin.Conclusions:Considering the anti-melanogenic activity and human safety,CCE is considered as a potential anti-melanogenic agent and may be effective for topical application for treating hyperpigmentation disorders. | Sang Suk Kim Min-Jin Kim Young Hun Choi Byung Kuk Kim Kwang Sik Kim Kyung Jin Park Suk Man Park Nam Ho Lee Chang-Gu Hyun | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 7 |
| 3 | Symmetric redox supercapacitor with conducting polyaniline electrodes显示文摘 | Kwang Sun Ryu Kwang Man Kim Nam-Gyu Park Yong Joon Park Soon Ho Chang | 2002 | Journal of Power Sources2002，，2： | 2 |
| 4 | HBV DNA and HBsAg Levels as Risk Predictors of Early and Late Recurrence after Curative Resection of HBV-related Hepatocellular Carcinoma显示文摘 | Won Sohn Yong-Han Paik Jong Man Kim Choon Hyuk Kwon Jae Won Joh Ju Yeon Cho Geum-Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Annals of Surgical Oncology2014，，7： | 2 |
| 5 | Structure Development during Flow of Ternary Blends of a Polyamide (Nylon46), a Thermotropic Liquid Crystal- line Polymer E Poly ( ester amide) 1, and a Thermoplastic Elastomer (EPDM) 显示文摘 | Yongsok Seo Soon Man Hong Kwang Ung Kim | 1997 | Macromolecules1997，30，： | 1 |
| 6 | Preparation and electrochemical properties of lithium-sulfur polymer batteries 显示文摘 | Byoung Ho Jeon Jin Hee Yeon Kwang Man Kim | 2002 | J Power Sources2002，109，1： | 1 |
| 7 | Electrochemical and physical characterization of lithium ionic salt doped polyaniline as a polymer electrode of lithium se?condary battery显示文摘 | Kwang Sun Ryu Kwang Man Kim Seong-Gu Kangv et a1 | 2000 | Synth Metals2000，10，： | 1 |
| 8 | Preparation and electrochemical properties of lithium-sulfur polymer batteries显示文摘 | Byoung Ho Jeon Jin Hee Yeon Kwang Man Kim | | 0，，01： | 1 |
| 9 | Electrochemical and physical characterization of lithium ionic salt doped polyaniline as a polymer electrode of lithium secondary battery显示文摘 | Kwang Sun Ryu Kwang Man Kim Seong-Gu Kang Gye Joong Lee Jinsoo Joo Soon Ho Chang | 2000 | Synthetic Metals2000，，3： | 1 |
| 10 | 显示文摘 | Kwang Hee Jung Hogi Kim Kwang Man Kim | 2011 | J Ap- pl Electrochem2011，41，5： | 1 |
| 11 | Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors显示文摘 | Yong Kwang Park Eun-Sook Park Doo Hyun Kim Sung Hyun Ahn Seung Hwa Park Ah Ram Lee Soree Park Hong Seok Kang Ji-Hyun Lee Jong Man Kim Suk-Koo Lee Keo-Heun Lim Nathalie Isorce Shuping Tong Fabien Zoulim Kyun-Hwan Kim | 2015 | Journal of Hepatology2015，，： | 1 |
| 12 | Capacity and cycle performance of a lithium-ion polymer battery using commercially available LiNiCoO2显示文摘 | KIM Jin-Chul Park Nam-Gyu | 2003 | Journal of Power Sources2003，123，3： | 1 |
| 13 | Symmetric redox supercapacitor with conducting polyaniline electrodes显示文摘 | Ryu Kwang Sun Kim Kwang Man Park Nam-guy | | 0，，： | 1 |
| 14 | Characteristics of PVDF-HFP/TiO2 composite membrane elec-trolytes prepared by phase inversion and conventional castingmethod显示文摘 | KIM Kwang Man PARK Nam-Gyu RYU Kwang Sun | 2006 | Electrochim Acta2006，51，： | 1 |
| 15 | 显示文摘 | Kim Kwang Man Park Nam-Gyu Ryu Kwang Sun | 2006 | Electrochimical Acta2006，51，26： | 1 |
| 16 | Time of hepatocellular carcinoma recurrence after liver resection and alpha‐fetoprotein Are important prognostic factors for salvage liver transplantation显示文摘 | Sanghoon Lee Choon Hyuck David Kwon Jong Man Kim Jae‐Won Joh Seung Woon Paik Bong‐Wan Kim Hee‐Jung Wang Kwang‐Woong Lee Kyung‐Suk Suh Suk‐Koo Lee | 2014 | Liver Transpl2014，，9： | 1 |
| 17 | Preparation and electrochemical properties of lithium - sulfur polymer batteries 显示文摘 | Byoung Ho Jeon Jin Hee Yeon Kwang Man Kim | 2002 | J Power Sources2002，109，： | 1 |
| 18 | Preparation and electrochemical properties of lithium-sulfur polymer batteries 显示文摘 | Byoung Ho Jeon Jin Hee Yeon Kwang Man Kim | 2002 | Journal of Power Sources2002，109，1： | 1 |
| 19 | Preparation and electrochemical properties of lithium-sulfur polymer batteries显示文摘 | Byoung Ho Jeon Jin Hee Yeon Kwang Man Kim | 2002 | J Power Sources2002，109，1： | 1 |
| 20 | Preparation and electrochemical properties of lithium-sulfur polymer batteries显示文摘 | BYOUNG HO JEON JIN HEE YEON KWANG MAN KIM | 2002 | J Power Sources2002，109，1： | 1 |
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