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| 1 | Development of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers for skin tissue engineering : Effects of topography, mechanical, and chemical stimuli显示文摘 | Kuppan P Vasanthan K S Sundaramurthi D | 2011 | Biomacromolecules2011，9，12： | 1 |
| 2 | Specific role of polymorphs of supporting titania in catalytic CO oxidation on gold 显示文摘 | Beck A Magesh G Kuppan B Schay Z Gesztic O Benk6T Viswanath R P Selvam P Viswanathan B Guczi L | 2011 | Catalysis Today2011，164，1： | 1 |
| 3 | Influence of EDM process parameters in deep hole drilling of Inconel 718显示文摘 | Kuppan P Rajadurai A Narayanan S | 2008 | The International Journal of Advanced Manufacturing Technology2008，38，12： | 1 |
| 4 | Influence of EDM process parameters in deep hole drilling of Inconel 718显示文摘 | Kuppan P Rajadurai A Narayanan S | 2008 | The International Journal of Advanced Manufacturing Technology2008，38，1： | 1 |
| 5 | Development of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers for skin tissue engineering:effects of topography,mechanical,and chemical stimuli显示文摘 | Kuppan P Vasanthan KS Sundaramurthi D | | 0，，09： | 1 |
| 6 | Phosphorus enrichment as a new composition in the solid electrolyte interphase of high-voltage cathodes and its effects on battery cycling显示文摘 | YANG P ZHENG J KUPPAN S | 2015 | Chemistry of Materials2015，27，21： | 1 |
| 7 | Hybrid Aluminium Metal Matrix Composite Reinforced With Si C and Ti B2显示文摘 | Johny James S Venkatesan K Kuppan P | 2014 | Procedia Engineering2014，97，： | 1 |
| 8 | Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway显示文摘Objective:To evaluate the anti-proliferative and apoptogenic activity of ethyl acetate extract from the leaves of Memecylon edule(EtAc-LME) in MKN-74,NUGC gastric cancer cells and non cancerous gastric mucous cells(GES-1),and to explore the mechanism of EtAc-LME induced apoptosis.Methods:The mechanism of EtAc-LME induced apoptosis was explored by analysing the activation of pro-caspases,PARP cleavage,expression of cytochrome-c (Cyt-c) was determined by western blotting,mRNA expression of Bcl-2,Bax by RT-PCR,loss of mitochondrial potential using DiOC6 dye,annexin binding assay and its influence on cell cycle arrest by flow cytometry.Results:The results indicated that EtAc-LME inhibited the gastric cancer cell growth in dose-dependent manner and cytotoxicity was more towards the gastric cancer cells(NUCC and MKN-74) compared to normal gastric cells(GES-1),suggesting more specific cytotoxicity to the malignant cells.Over expression of Cyt-c and subsequent activation of caspases-3 and down regulation of Bcl-2 and loss in mitochondrial potential in EtAc-LME treated MKN-74 and NUGC cells suggested that EtAc-LME induced apoptosis by mitochondrial dependent pathway.Conclusions:The present findings suggest that ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells emphasizing the importance of this traditional medicine for its potential in the treatment of gastric cancer. | VGM.Naidu Bandari Uma Mahesh Ashwini Kumar Giddam Kuppan Rajendran Dinesh Babu Jian Ding K Suresh babu B Ramesh Rajeswara Rao Pragada Gopalakrishnakone P | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 0 |
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