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| 1 | Influence of Various Materials on Biomechanical Behavior of Endocrown-Restored, Endodontically-Treated Mandibular First Molar: A 3D-Finite Element Analysis显示文摘To evaluate the effect of restorative materials on stress distribution of endodontically treated teeth, the 3D models of an endodontically treated mandibular fi rst molar, restoration, and cement layer were created. Three different materials(composite resin, ceramage and ceramic) were studied and two loading conditions(vertical and oblique load) were simulated. Mohr-Coulomb failure criterion of enamel, dentine, endocrown and cement were evaluated separately. It is indicated that under both loading conditions, the highest values of Mohr-Coulomb failure criterion were observed in Ceramage-restored group for remaining tooth structure while in ceramic-restored group for the restoration. Compared to composite resin and Ceramage, ceramic endocrown transferred less stress, namely was more protective to the tooth structure. | 陈彬文 马彦昭 WU Kunxue CHEN Hong LI Lu LIANG Liang LIU Jun 陈智 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，3： | 8 |
| 2 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 3 | Ascorbate oxidase electrochemical biosensor based on the biocompatible poly(3,4-ethylenedioxythiophene) matrices for agricultural application in crops显示文摘在庄稼的维生素 C (VC ) 是成功地 poly 基于 biocompatible 用 ascorbate oxidase (AO ) 决定了电气化学的生物传感器(3, 4-ethylenedioxythiophene )(PEDOT ) 矩阵,它被一步舞电极淀积技术容易在离子的液体微乳液准备。制作生物传感器显示了优秀 bioelectrocatalytic 性能到 VC 的氧化,宽线性范围,低察觉限制,快反应时间,好运作并且存储稳定性,在蔬菜庄稼的 VC 的决心的好结果显示制作生物传感器将是在近的未来的庄稼的生理、生物化学的研究的一个好候选人。 | Yang Ping Wen Li Min Lu Dong Li Ming Liu Hao Hua He Jing KunXu | 2012 | Chinese Chemical Letters2012，23，2： | 3 |
| 4 | Facile preparation of core-shell Si@Li4Ti5O12 nanocomposite as large-capacity lithium-ion battery anode显示文摘As a promising alternative anode material,silicon(Si)presents a larger capacity than the commercial anode to achieve large capacity lithium-ion batteries.However,the application of pure Si as anode is hampered by limitations such as volume expansion,low conductivity and unstable solid electrolyte interphase.To break through these limitations,the core-shell Si@Li4Ti5O12nanocomposite,which was prepared via in-situ self-assembly reaction and decompressive boiling fast concentration method,was proposed in this work.This anode combines the advantages of nano-sized Si particle and pure Li4Ti5O12(LTO)coating layer,improving the performance of the lithium-ion batteries.The Si@Li4Ti5O12 anode displays a high initial discharge/charge specific capacity of 1756/1383 m Ahg^-1 at 500 mAg^-1(representing high initial coulombic efficiency of 78.8%),a large rate capability(specific capacity of 620 mAhg^-1 at4000 mAg^-1),an outstanding cycling stability(reversible specific capacity of 883 mAhg^-1 after 150 cycles)and a low volume expansion rate(only 3.3% after 150 cycles).Moreover,the synthesis process shows the merits of efficiency,simplicity,and economy,providing a reliable method to fabricate large capacity Si@Li4Ti5O12nanocomposite anode materials for practical lithium-ion batteries. | Mengjing Liu Hanyang Gao Guoxin Hu Kunxu Zhu Hao Huang | 2020 | Journal of Energy Chemistry2020，29，1： | 3 |
| 5 | Genetic and Neutralization Properties of HIV-1 ENV Clones From Subtype B/BC/AE Infections in China 显示文摘 | Chong Huihui Hong Kunxue Zhao Chuntao | 2008 | J Acquit Immune Defic Syndr2008，47，5： | 1 |
| 6 | Relationship Between Syphilis and HIV Infections Among Men Who Have Sex With Men in Beijing, China显示文摘 | Yuhua Ruan Dongliang Li Xinxu Li Han-zhu Qian Wei Shi Xiaoxi Zhang Zhenkai Yang Xiaoyan Zhang Chen Wang Yingjie Liu Miao Yu Dong Xiao Chun Hao Hui Xing Kunxue Hong Yiming Shao | 2007 | Sexually Transmitted Diseases2007，，8： | 1 |
| 7 | Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B显示文摘HIV-1 Rev is an accessory protein that plays a key role in nuclear exportation,stabilization,and translation of the viral mRNAs.Rev of HIV-1 clade BC often shows a truncation of 16 AAs due to a premature stop codon at residue 101.This stop codon presents the highest frequency in clade BC and the lowest frequency in clade B.In order to discover the potential biological effect of this truncation on Rev activity and virus replication of clade BC,we constructed Rev expression vectors of clade BC with or without 16 AAs within C-terminal separately,and replaced the stop codon by Q in a CRF07_BC infectious clone.We found that 16 AAs truncation had no effect on expression and activity of Rev in clade BC.Also,the mutation from the stop codon to Q had no effect on virus replication of clade BC.Next,to investigate the effect of this truncation on Rev activity and replication capacity of clade B,Rev expression vectors of clade B carrying or lacking 16 AAs in C-terminal were constructed respectively,and residue Q at position 101 within Rev was substituted by the stop codon in a clade B infectious clone.It was found that 16 AAs truncation significantly down-regulated Rev expression and impaired clade B Rev activity.Furthermore,a Q-to-stop codon substitution within Rev significantly reduced viral replication fitness of clade B.These results indicate that the premature stop codon at residue 101 within Rev exerts diverse impact on viral replication among different HIV-1 clades. | Zheng Wang Xiaolin Ji Yanling Hao Kunxue Hong Liying Ma Dan Li Yiming Shao | 2020 | Virologica Sinica2020，35，2： | 1 |
| 8 | Community-Based Survey of HIV Transmission Modes among Injection Drug Users in Sichuan,China显示文摘 | Ruan Yuhua Chen Kanglin Hong Kunxue | 2004 | Sexually Transmitted Diseases2004，31，10： | 1 |
| 9 | Dissipative mechanism in Godunov‐type schemes显示文摘 | KunXu ZuowuLi | 2001 | Int J Numer Meth Fluids2001，，1： | 1 |
| 10 | Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort显示文摘During the early mid-1990s,a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1.However,AIDS progression in the former blood donors(FBDs)is various.The aim of this study is to assess human leukocyte antigen(HLA)class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression.A total of 353 FBDs were enrolled in the cohort including 294 ART na ve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects.The viral load and CD4/CD8 T cell counts were assessed in all subjects.Compared with HIV-seropositive group,the frequency of HLA-A*03 in control was significantly higher.After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes,detrimental effect of HLA Bw6/Bw6 homozygosity was also confirmed in the HIV-seropositive subjects.This study provides novel evidence on HLA class I allele distribution and association of HLA-A*03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs,which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression. | ZHANG WeiLun WANG Li HONG KunXue LIU YanXin SU Bing XU Cheng XU JianQin RUAN YuHua SHAO YiMin ZHENG DeXian | 2013 | Science China(Life Sciences)2013，56，11： | 0 |
| 11 | Analysis of Application of Environmental Engineering Construction in Ecological City显示文摘At present,with the continuous deterioration of the ecological environment and the gradual deepening of human understanding of the relationship between man and nature,the construction of an ecological city has become the trend and inevitable urban construction in the future.Finding harmonious development among cities,human beings,and the natural environment through the construction of the ecological environment is an inevitable choice for human and urban development.In order to provide sufficient theoretical exploration for the construction of ecological cities,this paper first introduced the two important concepts of ecological environment and environmental engineering and the necessity of ecological construction.On the basis of this,it analyzes the various obstacles and predicaments in the current construction of ecological cities and achieves the purpose of clarifying the problems;finally,it proposes corresponding countermeasures[1]. | Shutian Sun Kunxue Huang Yu Hu Zhixin Xing Qingjiang Su | 2018 | Smart Construction Research2018，2，4： | 0 |
| 12 | Impact of HIV Pretreatment Drug Resistance on Virological Failure After One-Year Antiretroviral Therapy--China,2018-2019显示文摘Summary What is already known about this topic?While antiretroviral therapy(ART)has been rapidly scaled-up among the population living with human immunodeficiency virus or acquired immune deficiency syndrome(HIV/AIDS)patients since 2016,pretreatment drug resistance(PDR)has also increased. | Miaomiao Li Chang Song Aobo Dong Jing Hu Ruihua Kang Hui Xing Yuhua Ruan Yiming Shao Kunxue Hong Lingjie Liao | 2022 | China CDC weekly2022，4，25： | 0 |
| 13 | MicroRNA 31 inhibits CD8^(+) T-cell function by increasing its sensitivity to type I interferon signaling in chronic viral infection显示文摘Chronic viral infections and malignant tumors can cause T cells to become dysfunctional and exhausted through two different associated immune statuses:inflammation and immunosuppression.Inflammatory immunity is a necessary step for the establishment of the immune response to control infection and cancer.However,once a pathogen cannot be cleared in time or a tumor continues to progress,an immunosuppressive environment involving various immune cells and cytokines may form,thereby promoting the persistence of the pathogen or tumor.Among those immune factors,type I interferons play a dual role by driving inflammation and inducing a variety of suppressive factors that limit immune responses in chronic infection and cancer. | Mingming Jia Yiming Shao Kunxue Hong | 2018 | Cellular & Molecular Immunology2018，15，5： | 0 |
| 14 | Quantum simulation of a general anti-PT-symmetric Hamiltonian with a trapped ion qubit显示文摘Non-Hermitian systems satisfying parity-time(PT)symmetry have aroused considerable interest owing to their exotic features.Anti-PT symmetry is an important counterpart of the symmetry,and has been studied in various classical systems.Although a Hamiltonian with anti-PT symmetry only differs from its PT-symmetric counterpart in a global phase,the information and energy exchange between systems and environment are different under them.It is also suggested theoretically that anti-PT symmetry is a useful concept in the context of quantum information storage with qubits coupled to a bosonic bath.So far,the observation of anti-PT symmetry in individual quantum systems remains elusive.Here,we implement an anti-PT-symmetric Hamiltonian of a single qubit in a single trapped ion by a designed microwave and optical control-pulse sequence.We characterize the anti-PT phase transition by mapping out the eigenvalues at different ratios between coupling strengths and dissipation rates.The full information of the quantum state is also obtained by quantum state tomography.Our work allows quantum simulation of genuine open-system feature of an anti-PT-symmetric system,which paves the way for utilizing non-Hermitian properties for quantum information processing. | Ji Bian Pengfei Lu Teng Liu Hao Wu Xinxin Rao Kunxu Wang Qifeng Lao Yang Liu Feng Zhu Le Luo | 2023 | Fundamental Research2023，3，6： | 0 |
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