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| 1 | Regulation of Rice Tillering by RNA-Directed DNA Methylation at Miniature Inverted-Repeat Transposable Elements显示文摘Tillering is a major determinant of rice plant architecture and grain yield.Here,we report that depletion of rice OsNRPD1a and OsNRPD1b,two orthologs of the largest subunit of RNA polymerase IV,leads to a high-tillering phenotype,in addition to dwarfism and smaller panicles.OsNRPD1a and OsNRPD1b are required for the production of 24-nt small interfering RNAs that direct DNA methylation at transposable elements(TEs)including miniature inverted-repeat TEs(MITEs).Interestingly,many genes are regulated either positively or negatively by TE methylation.Among them,OsMIR156d and OsMIR156j,which promote rice tillering,are repressed by CHH methylation at two MITEs in the promoters.By contrast,D14,which suppresses rice tillering,is activated by CHH methylation at an MITE in its downstream.Our findings reveal regulation of rice tillering by RNA-directed DNA methylation at MITEs and provide potential targets for agronomic trait enhancement through epigenome editing. | Le Xu Kun Yuan Meng Yuan Xiangbing Meng Min Chen Jianguo Wu Jiayang Li Yijun Qi | 2020 | Molecular Plant2020，13，6： | 9 |
| 2 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 3 | Face Masks in the New COVID-19 Normal: Materials, Testing,and Perspectives显示文摘The increasing prevalence of infectious diseases in recent decades has posed a serious threat to public health.Routes of transmission differ,but the respiratory droplet or airborne route has the greatest potential to disrupt social intercourse,while being amenable to prevention by the humble facemask.Different types of masks give different levels of protection to the user.The ongoing COVID-19 pandemic has even resulted in a global shortage of face masks and the raw materials that go into them,driving individuals to self-produce masks from household items.At the same time,research has been accelerated towards improving the quality and performance of face masks,e.g.,by introducing properties such as antimicrobial activity and superhydrophobicity.This review will cover mask-wearing from the public health perspective,the technical details of commercial and home-made masks,and recent advances in mask engineering,disinfection,and materials and discuss the sustainability of mask-wearing and mask production into the future. | Ming Hui Chua Weiren Cheng Shermin Simin Goh Junhua Kong Bing Li Jason Y.CLim Lu Mao Suxi Wang Kun Xue Le Yang Enyi Ye Kangyi Zhang Wun Chet Davy Cheong Beng Hoon Tan Zibiao Li Ban Hock Tan Xian Jun Loh | 2020 | Research2020，，1： | 5 |
| 4 | Radiation response of the central nervous system显示文摘 | Schultheiss TE Kun LE Ang KK | 1995 | Int J Radiat Oncol Biol Phys1995，31，： | 1 |
| 5 | Radiation response of the central nervous system显示文摘 | Schulthesis TE Kun LE Ang KK | 1995 | Int J Radiat Oncol Biol Phys1995，31，： | 1 |
| 6 | Intracranial germino- ma: on whole-ventricular irradiation 显示文摘 | Roberge D Kun LE Freeman CR | 2005 | Pediatr Blood Cancer2005，44，4： | 1 |
| 7 | A detrimental effect of a combined chemotherapy-radiotherapy approach in chil- dren with diffuse intrinsic brain stem gliomas? 显示文摘 | Freeman CR Kepner J Kun LE | 2000 | Int J Radiat Oncol Biol Phys2000，47，3： | 1 |
| 8 | 显示文摘 | Zhang Le Hart Pengde Wang Kun | 2012 | Journal of Alloys and Compounds2012，541，： | 1 |
| 9 | Multilayer struc- tured MFI-type titanosilicate: Synthesis and catalytic proper-ties in selective epoxidation of bulky molecules 显示文摘 | Wang Jianggan Xu Le Zhang Kun | 2012 | J Catal2012，288，： | 1 |
| 10 | Radiation response of the central nervous system显示文摘 | Schultheiss TE Kun LE Ang KK | | 0，，05： | 1 |
| 11 | Childhood centra]nervous system leukemia:historical perspectives,current therapy,and acute neurological sequelae显示文摘 | Laningham FH Kun LE Reddick WE | 2007 | Neuroradiology2007，49，11： | 1 |
| 12 | Adult Secondhand Smoke Exposure—Shanghai Municipality,2018显示文摘Summary What is already known on this topic?The average secondhand smoke exposure rate was 68.1%in China in 2018.The World Health Organization suggests that legislation must be used to achieve a 100%smoke-free environment and protect nonsmokers from secondhand smoke.What is added by this report? | Yuanqiao Sun De Chen Jian Wang Lin Xiao Kun Xu Chenchen Xie Kunlei Le Zhengyang Gong Xiaoxian Jia Jingrong Gao Liming Wu | 2020 | China CDC weekly2020，2，22： | 1 |
| 13 | Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function显示文摘 | Merchant TE Kiehna EN Kun LE | 2006 | J Neurosurg2006，104，2： | 1 |
| 14 | Radiation response of the central nervous system 显示文摘 | Schultheiss TE Kun LE Ang KK | 1995 | Int J Radiat Oncol Phys1995，31，5： | 1 |
| 15 | Influence of Oil and Water Components on Wall-sticking Occurrence Temperature in High Water-cut Crude Oil Pipeline显示文摘To study the wall-sticking phenomenon and prevent pipeline blockage accidents,two analytical methods are used to evaluate the influence of different crude oil components on the wall-sticking occurrence temperature(WSOT).The WSOT and the interactions among oil,water,and surface solids are measured and calculated by various devices under different values of the wax content,water pH,and salinity.The results show that there is greater correlation between the wax content and WSOT than between resins/asphaltenes and WSOT.Furthermore,the wax content,water pH,and salinity have different effects on WSOT.There is generally a positive correlation between wax content and WSOT,whereas the maximum WSOT occurs when the water pH is in the range 5.7–6.5,and decreases under more acidic or alkaline conditions.As the salinity increases,WSOT decreases slightly,but quickly becomes saturated.In terms of interactions,variations in the interfacial tension and adhesion work with pH and salinity are consistent with that of WSOT,while the contact angle exhibits the opposite relation. | Cheng Xianwen Huang Qiyu Wang Kun Cui Yue Hei Shunan Yu Le | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，4： | 1 |
| 16 | Radiation response of the central nervous system 显示文摘 | Schultheiss TE Kun LE Ang KK | 1995 | Int J Radiat Oncol Biol Phys1995，31，： | 1 |
| 17 | Disruption of Klf4 in Villin-Positive Gastric Progenitor Cells Promotes Formation and Progression of Tumors of the Antrum in Mice显示文摘 | Qiang Li Zhiliang Jia Li Wang Xiangyu Kong Qi Li Kun Guo Dongfeng Tan Xiangdong Le Daoyan Wei Suyun Huang Lopa Mishra Keping Xie | 2012 | Gastroenterology2012，，3： | 1 |
| 18 | Serum cytokine profiles associated with clinical presentation in Vietnamese infected with hepatitis B virus显示文摘 | Le H. Song Vu Q. Binh Dinh N. Duy Jürgen F.J. Kun Thomas C. Bock Peter G. Kremsner Adrian J.F. Luty | 2002 | Journal of Clinical Virology2002，，1： | 1 |
| 19 | Survival after recurrence of Ewing's tumors: the St Jude Children's Research Hospital experience, 1979~1999显示文摘 | Rodriguez GC Billups CA Kun LE | 2002 | Cancer2002，94，2： | 1 |
| 20 | Phase II trial of con-formal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function显示文摘 | Merchant TE Kiehna EN Kun LE | | 0，，： | 1 |
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