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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 3 | Treatment efficacy of radiof requency ablation of 338 patients with hepatic malignant tumor and the relevant complications显示文摘AIM: To investigate the treatment efficacy of radiofrequency ablation (RFA) of hepatic malignant tumor and the relevant complications.METHODS: A total of 338 patients with 763 hepatic tumors underwent ultrasound-guided RFA (565 procedures).There were 204 cases of hepatic cellular carcinoma (HCC)with 430 tumors, the mean largest diameter was 4.0 cm.Of them, 48 patients (23.5%) were in stages Ⅰ-Ⅱ (UICC Systems) and 156 (76.5%) in stages Ⅲ-Ⅳ There were 134 cases of metastatic liver carcinoma (MLC), with 333metastases in the liver, the mean diameter was 4.1 cm,the liver metastases of 96 patients (71.6%) came from gastrointestinal tract. Ninety-three percent of the 338patients were treated using the relatively standard protocol. Crucial attention must be paid to monitor the abnormal changes in ultrasound images as well as the vital signs of the patients to find the possible hemorrhage and peripheral structures injury in time. The tumors were considered as ablated completely, if no viability was found on enhanced CT within 24 h or at 1 mo after RFA. These patients were followed up for 3-57 mo.RESULTS: The ablation success rate was 93.3% (401/430tumors) for HCC and was 96.7% (322/333 tumors) for MLC. The local recurrence rate for HCC and MLC was 7.9% (34/430 tumors) and 10.5% (35/333 tumors),respectively. A total of 137 patients (40.5%) underwent 2-11times of repeated ablations because of tumor recurrence or metastasis. The 1st, 2nd, and 3rd year survival rate was84.6%, 66.6%, and 63.1%, respectively;the survival rate from 48 patients of Ⅰ-Ⅱ stage HCC was 93.7%, 80.4%,and 80.4%, respectively. The major complication rate in this study was 2.5% (14 of 565 procedures), which consisted of 5 hemorrhages, 1 colon perforation, 5 injuries of adjacent structures, 2 bile leakages, and 1 skin burn.CONCLUSION: RFA, as a minimally invasive local treatment,has become an effective and relatively safe alternative for the patients of hepatic malignant tumor, even of advanced liver tumor, tumor recurrence, and liver metastases. Knowledge about possible complications and their control may increase the treatment efficacy and help to promote the use of RFA technique. | Min-Hua Chen Wei Yang Kun Yan Wen Gao Ying Dai Yan-Bin Wang Xiao-Peng Zhang Shan-Shan Yin | 2005 | World Journal of Gastroenterology2005，11，40： | 25 |
| 4 | Evaluation of contrast-enhanced ultrasound for diagnosis of dysplastic nodules with a focus of hepatocellular carcinoma in liver cirrhosis patients显示文摘Objective: To compare the enhancement features of dysplastic nodules with a focus of hepatocellular carcinoma(DN-HCC) versus HCC and regenerative nodules(RN) in cirrhotic patients.Methods: One hundred and ninety-three cirrhotic patients were enrolled in this study; they had 215 focal liver lesions, 1.0-3.5 cm in size, which were examined using contrast-enhanced ultrasound(CEUS) with Sono Vue?and diagnosed as HCC, RN or DN-HCC by biopsy. Samples were obtained using 18-gauge needles in the different enhanced areas. The enhancement features of DN-HCC, HCC and RN were evaluated.Results: There were 86 HCC lesions, 102 RN lesions, and 27 DN-HCC lesions diagnosed by biopsy. Of 86 HCC lesions, 87.2%(75/86) showed complete enhancement during the arterial phase, and 12.8%(11/86) had inhomogeneous enhancement, with no enhancement in the central area during the arterial phase; 100%(86/86) exhibited washout during the late phase. Of 102 RN lesions, 95.1%(97/102) had delayed or simultaneous enhancement during the arterial phase, and 4.9%(5/102) displayed slight enhancement during the arterial phase; 26.5%(27/102) exhibited washout and 73.5%(75/102) exhibited no washout during the late phase. In 27 DN-HCC lesions, only part of the lesions enhanced during the arterial phase and washed out during the late phase; the other areas had delayed or simultaneous enhancement during the arterial phase, and 29.6%(8/27) exhibited slight washout in the late phase. In 86 HCCs, the pathological feature was HCC in the enhanced area of 75 lesions, hepatocellular fatty degeneration in the slightly enhanced area of 7 lesions, and hepatocellular necrosis in the unenhanced area and HCC in the enhanced area of 4 lesions. In 102 RNs, the pathological diagnosis was hepatocyte proliferation with or without fatty degeneration. In 27 DN-HCCs, the pathological feature was HCC in the enhanced area and hepatocyte regeneration in the unenhanced area.Conclusions: CEUS is useful for the diagnosis of focal liver lesions in cirrhotic patients. CEUS can help determine the progression from RN to DN-HCC to HCC by analyzing the hemodynamics. CEUS can promote the diagnostic accuracy of a biopsy by providing more accurate information on the site of the biopsy. | Wei Wu Minhua Chen Kun Yan Yin Dai Shanshan Yin Wei Yang Zhihui Fan | 2015 | Chinese Journal of Cancer Research2015，27，1： | 15 |
| 5 | Magnolol additive as a replacer of antibiotic enhances the growth performance of Linwu ducks显示文摘Magnolol rich in Magnolia officinalis is a bioactive polyphenolic compound. The aim of this study was to examine the effects of magnolol additive(MA) on growth performance, expression levels of antioxidantrelated genes, and intestinal mucosal morphology of Linwu ducks aged from 49 to 70 days, comparing with that of an antibiotic additive(colistin sulfate [CS]). A total of 275,49-day-old ducks were assigned to5 groups with 5 cages of 11 ducks each and fed diets supplemented with 0,100, 200 and 300 mg of MA/kg and 300 mg of CS/kg for 3 weeks, respectively. The results showed that the average daily body weight gain(ADG) was increased significantly in MA-fed groups(200 and 300 mg/kg), compared with the basal diet(BD) group(P < 0.05). The mRNA levels of superoxide dismutase-1(SOD1), manganese superoxide dismutase-2(MnSOD2) and catalase(CAT) were also increased significantly in MA groups(P < 0.05). In addition, hematoxylin and eosin staining revealed that Linwu ducks fed the diets with MA had more intact intestinal mucosa than those fed the BD and CS diets. In addition, ileal villus height, ileal villus height/crypt depth ratio(V/C) and duodenal V/C were also improved significantly(P < 0.05). Taken together, these data demonstrated that MA is an effective feed additive to enhance the growth performance of the Linwu ducks by improving the antioxidant and intestinal mucosal status, suggesting that MA will be a potential additive to replace antibiotic(CS). | Qian Lin Jianfei Zhao Kun Xie Yushi Wang Guili Hu Guitao Jiang Qiuzhong Dai Zhiyong Fan Jianhua He Xi He De-Xing Hou | 2017 | Animal Nutrition2017，，2： | 14 |
| 6 | Efficient spectrum prediction and inverse design for plasmonic waveguide systems based on artificial neural networks显示文摘In this paper, we propose a novel approach to achieve spectrum prediction, parameter fitting, inverse design, and performance optimization for the plasmonic waveguide-coupled with cavities structure(PWCCS) based on artificial neural networks(ANNs). The Fano resonance and plasmon-induced transparency effect originated from the PWCCS have been selected as illustrations to verify the effectiveness of ANNs. We use the genetic algorithm to design the network architecture and select the hyperparameters for ANNs. Once ANNs are trained by using a small sampling of the data generated by the Monte Carlo method, the transmission spectra predicted by the ANNs are quite approximate to the simulated results. The physical mechanisms behind the phenomena are discussed theoretically, and the uncertain parameters in the theoretical models are fitted by utilizing the trained ANNs.More importantly, our results demonstrate that this model-driven method not only realizes the inverse design of the PWCCS with high precision but also optimizes some critical performance metrics for the transmission spectrum. Compared with previous works, we construct a novel model-driven analysis method for the PWCCS that is expected to have significant applications in the device design, performance optimization, variability analysis,defect detection, theoretical modeling, optical interconnects, and so on. | TIAN ZHANG JIA WANG QI LIU JINZAN ZHOU JIAN DAI XU HAN YUE ZHOU KUN XU | 2019 | Photonics Research2019，7，3： | 13 |
| 7 | Multiple fault diagnosis of down-hole conditions of sucker-rod pumping wells based on Freeman chain code and DCA显示文摘It is important to achieve continuous, stable and efficient pumping well operation in actual oilfield operation. Down-hole pumping well working conditions can be monitored in real-time and a reasonable production scheme can be designed when computer diagnosis is used. However, it is difficult to make a comprehensive analysis to supply efficient technical guidance for operation of the pumping well with multiple faults of down-hole conditions, which cannot be effectively dealt with by the common methods. To solve this problem, a method based on designated component analysis (DCA) is used in this paper. Freeman chain code is used to represent the down-hole dynamometer card whose important characteristics are extracted to construct a designated mode set. A control chart is used as a basis for fault detection. The upper and lower control lines on the control chart are determined from standard samples in normal working conditions. In an incompletely orthogonal mode, the designated mode set could be divided into some subsets in which the modes are completely orthogonal. The observed data is projected into each designated mode to realize fault detection according to the upper and lower control lines. The examples show that the proposed method can effectively diagnose multiple faults of down-hole conditions. | LI Kun GAO Xian-wen YANG Wei-bing DAI Ying-long TIAN Zhong-da | 2013 | Petroleum Science2013，10，3： | 12 |
| 8 | Relationship between circumcision and human papillomavirus infection: a systematic review and meta-analysis显示文摘男割礼(MC ) 被报导减少人的乳头状瘤病毒(HPV ) 在人的流行。然而,功效仍然保持不精确。这研究的目的是进行系统的评论和元分析估计在 MC 和生殖器的 HPV 感染和生殖器的肉赘之间的关系。科学的 PUBMED, EMBASE,和网从开始被寻找到 2015 年 3 月 22 日。我们识别了 30 份报纸,包括 12149 的一个总数割除并且与生殖器的 HPV 或生殖器的肉赘为割礼的协会被评估的 12252 个异教的人。与是的人相比,没割除的、割除的人可能有生殖器的 HPV 流行的显著地减少的机会(机会比率[或] :0.68;95% 信心间隔[95% CI ] :0.56-0.82 ) 。在 MC 和新感染的生殖器的 HPV 获得之间没有重要协会(或:0.99;95% CI:0.62-1.60 ) ,生殖器的 HPV 清理(或:1.38;95% CI:0.96-1.97 ) ,并且生殖器的肉赘的流行(或:1.17;95% CI:0.63-2.17 ) 。这元分析建议割礼减少生殖器的 HPV 感染的流行。然而,没有清楚的证据被发现那割礼与减少的 HPV 获得被联系,增加的 HPV 清理,或减少生殖器的肉赘的流行。更多的研究被要求足够地在 HPV 感染和生殖器的肉赘的流行的获得和清理上评估 MC 的效果。 | Yi-Ping Zhu Zhong-Wei Jia Bo Dai Ding-Wei Ye Yun-Yi Kong Kun Chang Yue Wang | 2017 | Asian Journal of Andrology2017，19，1： | 11 |
| 9 | Intraperitoneal hemorrhage during and after percutaneous radiofrequency ablation of hepatic tumors: reasons and management显示文摘Background Introperitoneal hemorrhage is one of the mos t common complications of radiofrequency (RF) ablation of hepatic tumors. This study was designed to investigate the reason and management of intraperitoneal h emorrhage occurred during or after percutaneous RF ablation of hepatic tumors. Methods Three hundred and fifty-six patients with hepatic tumo rs have been treated at 592 procedures of ultrasound guided RF ablation. Intrap eritoneal hemorrhage occurred in 5 patients (0.8%). The reasons and management of intraperitoneal hemorrhage in these 5 cases were retrospectively analyzed. Results Two patients with liver metastasis and one hepatocellul ar carcinoma (HCC) patient suffered from hemorrhage during the RF treatment. Tw o patients with recurrent HCC after surgery developed hemorrhage 20 minutes or 4 hours after RF treatment. One case of hemorrhage was due to the inappropriate electrode positioning induced liver laceration while treating a 1 cm liver metas tasis near the liver capsule. One was due to the injury of a small vessel by th e RF needle in another liver metastasis patient. Three cases were due to tumor rupture with two cases induced by cough or position change after treating large protruding HCC lesions. Four (80%) of the 5 cases of hemorrhage were rapidly id e ntified by ultrasound. The causes and sites of bleeding during the RF treatment in three cases were confirmed through ultrasound, which were successfully treat ed using RF coagulation to achieve hemostasis of the bleeding site. Two patient s with post-ablation hemorrhage recovered in one hour and 24 hours, respectivel y after given blood transfusion and other conservative measures. No surgical in tervention was required. Two patients died of wide spread metastasis 23-36 mon ths afterwards and the other three patients have lived for 18-25 months to date . Conclusions It is important to perform close monitoring during and after RF ablation in order to identify intraperitoneal hemorrhage in time. RF ablation of the bleeding sites was a simple and effective management when the bleeding site could be confirmed by ultrasound. The hemorrhage due to the rupt ure of large and protruding liver tumors could be serious and should be consider ed as contraindication for RF treatment. | CHEN Min-hua DAI Ying YAN Kun YANG Wei GAO Wen WU Wei LIAO Sheng-ri HAO Chun-yi | 2005 | Chinese Medical Journal2005，，20： | 10 |
| 10 | Computer-assisted preoperative planning for proximal humeral fractures by minimally invasive plate osteosynthesis显示文摘 | Chen Yanxi Zhang Kun Qiang Minfei Li Haobo Dai Hao | 2014 | Chinese Medical Journal2014，，18： | 9 |
| 11 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 12 | Toxicarioside A inhibits SGC-7901 proliferation,migration and invasion via NF-κB/bFGF signaling显示文摘AIM:To investigate the inhibitory role of toxicarioside A on the gastric cancer cell line human gastric cancer cell line(SGC-7901) and determine the underlying molecular mechanism.METHODS:After SGC-7901 cells were treated with toxicarioside A at various concentrations(0.5,1.5,4.5,9.0 μg/mL) for 24 h or 48 h,cell viability was determined by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl2H-tetrazolium bromide assay,and the motility and invasion of tumor cells were assessed by the Transwell chamber assay.Immunofluorescence staining,reverse transcription polymerase chain reaction and Western blotting were performed to detect the expression of basic fibroblast growth factor(bFGF) and fibroblast growth factor receptor-1(FGFR1),and nuclear factorkappa B(NF-κB) activation was examined by electrophoretic mobility shift assay.RESULTS:The results showed that toxicarioside A was capable of reducing cell viability,inhibiting cell growth,and suppressing cell migration and invasion activities in a time-and dose-dependent manner in SGC-7901 cells.Further analysis revealed that not only the expression of bFGF and its high-affinity receptor FGFR1 but also the NF-κB-DNA binding activity were effectively blocked by toxicarioside A in a dose-dependent manner compared with the control group(P < 0.05 or P < 0.01).Interestingly,application of the NF-κB specific inhibitor,pyrrolidinedithiocarbamate(PDTC),to SGC-7901 cells significantly potentized the toxicarioside A-induced down-regulation of bFGF compared with the control group(P < 0.05).CONCLUSION:These findings suggest that toxicarioside A has an anti-gastric cancer activity and this effect may be achieved partly through down-regulation of NF-κB and bFGF/FGFR1 signaling. | Jun-Li Guo Shao-Jiang Zheng Yue-Nan Li Wei Jie Xin-Bao Hao Tian-Fa Li Li-Ping xia Wen-Li Mei Feng-Ying Huang Yue-QiongKong Qi-Yi He, Kun Yang Guang-Hong Tan Hao-Fu Dai | 2012 | World Journal of Gastroenterology2012，18，14： | 8 |
| 13 | Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study显示文摘 | GONG Yi SHI Guo-chao WAN Huan-ying YANG Kun PAN Chun-ming CHENG Qi-jian DAI Ran-ran LI Qing-yun LI Min ZHOU Min GUO Yi | 2013 | Chinese Medical Journal2013，，23： | 8 |
| 14 | Ellipsoidal bounding set-membership identification approach for robust fault diagnosis with application to mobile robots显示文摘A robust fault diagnosis approach is developed by incorporating a set-membership identification(SMI) method. A class of systems with linear models in the form of fault related parameters is investigated, with model uncertainties and parameter variations taken into account explicitly and treated as bounded errors. An ellipsoid bounding set-membership identification algorithm is proposed to propagate bounded uncertainties rigorously and the guaranteed feasible set of faults parameters enveloping true parameter values is given. Faults arised from abrupt parameter variations can be detected and isolated on-line by consistency check between predicted and observed parameter sets obtained in the identification procedure. The proposed approach provides the improved robustness with its ability to distinguish real faults from model uncertainties, which comes with the inherent guaranteed robustness of the set-membership framework. Efforts are also made in this work to balance between conservativeness and computation complexity of the overall algorithm. Simulation results for the mobile robot with several slipping faults scenarios demonstrate the correctness of the proposed approach for faults detection and isolation(FDI). | Bo Zhou Kun Qian Xudong Ma Xianzhong Dai | 2017 | Journal of Systems Engineering and Electronics2017，28，5： | 7 |
| 15 | Flexible conductive polymer composites for smart wearable strain sensors显示文摘Wearable strain sensors based on flexible conductive polymer composites(FCPCs)have attracted great attention due to their applications in the fields of human–machine interaction,disease diagnostics,human motion detection,and soft robotic skin.In recent decades,FCPC‐based strain sensors with high stretchability and sensitivity,short response time,and excellent stability have been developed,which are expected to be more versatile and intelligent.Smart strain sensors are required to provide wearable comfort,such as breathability,selfcooling ability,and so forth.To adapt to the harsh environment,wearable strain sensors should also be highly adaptive to protect the skin and the sensor itself.In addition,portable power supply system,multisite sensing capability,and multifunctionality are crucial for the next generation of FCPC‐based strain sensor. | Kangkang Zhou Kun Dai Chuntai Liu Changyu Shen | 2020 | SmartMat2020，1，1： | 7 |
| 16 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 17 | Influence of Gd doping on the absolute quantum efficiency and lifetime of Eu_xGd_(1-x)(TTA)_3 phens显示文摘Absolute quantum yield(Φ) is one of the most important parameters to evaluate the potential of novel materials.Lanthanide complexes Eu_xGd_(1-x)(TTA)3phens are synthesized with the ratio of Gd^(3+) dopant concentration ranging from 10%to 90%to improve the absolute quantum yield.Eu_xGd_(1-x)(TTA)_3phens possess similar infrared and ultraviolet spectra,showing that they have similar molecular structures.The absolute emission quantum yields of Eu_xGd_(1-x)(TTA)_3phens are determined using a fluoromax-4spectrofluorometer equipped with an integrating sphere.The fluorescence lifetimes of the Eu_xGd_(1-x)(TTA)_3phens are measured in the same experiment.It was found that both absolute quantum yields and fluorescence lifetimes of Eu_xGd_(1-x)(TTA)_3phens are of quasi-periodic variation with the change of the Gd^(3+)dopant concentrations.The absolute quantum efficiency and fluorescence lifetime vary with respect to the Gd content in an opposite fashion,indicating that the rate of energy absorption by the Eu_xGd_(1-x)(TTA)_3phens and the conversion to light energy is critical for the absolute quantum efficiency.The radiative rate constant K_r and non-radiative rate constant K_(nr) are calculated.The dependence of K_r and K_(nr) on the Gd^(3+) dopant concentrations is very similar to that of absolute quantum efficiency.The radiation rate constant K_r and absolute quantum efficiency have a linear relationship. | Ting-Ting Dai Lei Liu Dong-Liang Tao Shi-Gang Li HongZhang Yu-Min Cui Yong-Zhong Wang Ji-Tang Chen Kun Zhang Wen-Zhong Sun Xiao-Yun Zhao gel Liu | 2014 | Chinese Chemical Letters2014，25，6： | 6 |
| 18 | Rapid genetic diagnosis and prenatal diagnosis of spinal muscular atrophy by denaturing high-performance liquid chromatography显示文摘针的肌肉发达的萎缩(SMA ) 是普通正染色体的后退的神经与肌的混乱(1 在 6000 ~ 10 000 出生) 在 5q13 在 SMN1 基因由变化引起了。病人们显示出的 SMA 的更多的 than90%-98% SMN1 的同型结合的删除,它证明了在 SMA 的诊断有用。但是因为高度相应的基因的存在,它被妨碍,在 SMN1 和 SMN2 之间的核苷酸失配上的 SMN2.Based,下列二 DNA 测试通常被执行:单个海滨的 conformational 多型性(SSCP ) 和聚合酶链反应(PCR ) 由限制酶消化列在后面。在我们开发了的这研究为由使中毒的 SMA 的快速的基因诊断的一个新方法高效的液体层析(DHPLC ) 它在检测 SMN1 的同型结合的删除基于人 duplexes 和异种 duplexes 的不同保留。基因、出生前诊断被 DHPLC 为一个 SMA 家庭成功地执行,它为检测 SMN1 的删除作为一种快速、有效的技术被证实。 | ZHU Hai-yan WU Ling-qian PAN Qian TANG Bei-sha LIANG De-sheng LONG Zhi-gao DAI He-ping XIA Kun XIA Jia-hui | 2006 | Chinese Medical Journal2006，，14： | 5 |
| 19 | Broadband photonic radio frequency(RF) channelization based on coherent optical frequency combs and polarization I/Q demodulation显示文摘In this work,we analyze and demonstrate a novel photonic-assisted broadband and high-resolution radio frequency(RF) channelization scheme based on dual coherent optical frequency combs(OFCs),regular optical de-muxes,and polarization I/Q demodulators in theory and experiment.The use of two coherent combs avoids precise optical alignment,and a numerical filter in digital signal processor(DSP) enables an ideal rectangular frequency response in each channel without any ultra-narrow optical filters.Besides,due to the use of polarization I/Q demodulation,ambiguous frequency estimate in direct detection can be avoided and the amplitude,phase mismatch in traditional I/Q demodulation can be mitigated.In experiment,we use two coherent OFCs with the free spectrum range(FSR) of about 40 GHz to demonstrate the channelization scheme with seven channels,500 MHz channel spacing and frequency coverage from 3.75 GHz to 7.25 GHz.The input RF tones are accurately down-converted to an intermediate frequency(IF) with a maximum frequency error of 110 kHz.Meanwhile,crosstalk and spurious free dynamic range(SFDR) of the scheme are also discussed. | DAI YiTang XU Kun XIE XiaoJun YAN Li WANG RuiXin LIN JinTong | 2013 | Chinese Science Bulletin2013，58，7： | 5 |
| 20 | Expression of reconstructive hF Ⅷ in the hrDNA by using hrDNA targeting vector显示文摘Our lab has constructed a new nonviral vec-tor—hrDNA targeting vector(pHrneo). pHrneo is a human derived vector that can target gene into human ribosomal DNA(hrDNA) locus. In this study, we inserted expression cassette of reconstructive hF Ⅷ (hFVIII-BDDAK39) to pHrneo to construct targeting vector: pHrneo-BDDAK39. Through electroporation of pHrneo-BDDAK39 into HT1080 cells, we identified the homologous recombinants by PCR and Southen blotting, and tested the expression of hFVIII- BDDAK39 in the hrDNA locus. The hFⅧ-BDDAK39 was successfully targeted into hrDNA locus of HT-1080 by pHrneo-BDDAK39, and the efficiency of site-specific inte-gration was 2.0×10?5. hFⅧ-BDDAK39 in hrDNA locus of HT-1080 is found to be able to express efficiently (32±5 ng·106 cells?1·24 h?1). Targeting vector pHrneo-BDDAK39 can find use in gene therapy for hemophilia. | LIU Xionghao LIU Mujun SHE Hua WEN Lu XUE Zhigang LIANG Desheng CAI Fang PAN Qian LONG Zhigao WU Lingqian DAI Heping XIA Kun XlA Jiahui | 2005 | Chinese Science Bulletin2005，50，19： | 5 |
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