|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation显示文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury. | Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu | 2017 | Neuroscience Bulletin2017，33，3： | 9 |
| 2 | Geophysical Features of the Ore-Controlling Fault in the Chang'an Gold Deposit, Southern Yunnan Province显示文摘The Ailao Mountain is one of the most important metallogenic belts of polymetallic deposits in the Sanjiang region,southwestern China.Located in the southern segment of this metallogenic belt,the newly-discovered Chang’an gold deposit is large in scale(Fig.1A),and has attracted much attention among geologists.The | LI Hua ASKAR ZHOU Yunman ZHANG Wei WU Wenxian ZHOU Yimin ZHOU Kuiwu | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 1 |
| 3 | Study of the Quantitative Diagnosis Scale of Blood Stasis Syndrome显示文摘 | Kuiwu Yao Jie Wang Jingbai Zhong Jitao Wu Juzheng Fang Cuiling Zhu Qiaru Wang Zaiyi Wang | 2006 | Journal of US-China Medical Science2006，3，3： | 0 |
| 4 | Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure显示文摘Ischemic heart failure(HF)remains a leading cause of morbidity and mortality.Maintaining homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF progression.Methyltransferase-like protein 13(Mettl13)has been shown to regulate protein translation efficiency by acting as a protein lysine methyltransferase,but its role in cardiac pathology remains unexplored.This study aims to characterize the roles and mechanisms of Mettl13 in cardiac contractile function and HF.We found that Mettl13 was downregulated in the failing hearts of mice post-myocardial infarction(MI)and in a cellular model of oxidative stress.Cardiomyocyte-specific overexpression of Mettl13 mediated by AAV9-Mettl13 attenuated cardiac contractile dysfunction and fibrosis in response to MI,while silencing of Mettl13 impaired cardiac function in normal mice.Moreover,Mettl13 overexpression abrogated the reduction in cell shortening,Ca^(2+)transient amplitude and SERCA2a protein levels in the cardiomyocytes of adult mice with MI.Conversely,knockdown of Mettl13 impaired the contractility of cardiomyocytes,and decreased Ca^(2+)transient amplitude and SERCA2a protein expression in vivo and in vitro.Mechanistically,Mettl13 impaired the stability of c-Cbl by inducing lysine methylation of c-Cbl,which in turn inhibited ubiquitination-dependent degradation of SERCA2a.Furthermore,the inhibitory effects of knocking down Mettl13 on SERCA2a protein expression and Ca^(2+)transients were partially rescued by silencing c-Cbl in H_(2)O_(2)-treated cardiomyocytes.In conclusion,our study uncovers a novel mechanism that involves the Mettl13/c-Cbl/SERCA2a axis in regulating cardiac contractile function and remodeling,and identifies Mettl13 as a novel therapeutic target for ischemic HF. | Shuting Yu ZhiYong Sun Xiuzhu Wang Tiantian Ju Changhao Wang Yingqi Liu Zhezhe Qu KuiWu Liu Zhongting Mei Na Li Meixi Lu Fan Wu Min Huang Xiaochen Pang Yingqiong Jia Ying Li Yaozhi Zhang Shunkang Dou Jianhao Jiang Xin Li Baofeng Yang Weijie Du | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
| 5 | Loss of NB-3 Aggravates Cerebral Ischemia by Impairing Neuron Survival and Neurite Growth显示文摘2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参加评选,会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过专家对参评者论文和现场报告的综合评判,评出一等奖、二等奖、三等奖、特别奖、最佳表达奖、最佳答辩奖和最佳图表奖共11名。从2013年第6期开始,《生理通讯》将陆续转载获奖者的参评论文各一篇,以飨读者。 | Xin Huang Jia Sun Tong Zhao Kuiwu Wu Kazutada Watanabe Zhi-Cheng Xiao Ling-ling Zhu Ming Fan | 2014 | 生理通讯2014，33，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员