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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 3 | Deep brain stimulation for intractable pain:A 15-year experience显示文摘 | Krishan K Cory T Rahul NK | 1997 | Nanrosurgery1997，40，4： | 1 |
| 4 | Standardization of Method for Lactoperoxidase Assay in Milk显示文摘 | RAJESH K KRISHAN L BHATIA | 1999 | Lait1999，79，： | 1 |
| 5 | Marked limb bilateral asymmetry in an agricultural endogamous population of North India 显示文摘 | Krishan K | 2011 | Am J Hum Biol2011，23，5： | 1 |
| 6 | Chemical structure and physical properties of diamond-like amorphous carbon films prepared by magnetron sputtering显示文摘 | Cho N H Krishan K M Hopper C B | 1990 | Jour Mater Res1990，5，11： | 1 |
| 7 | Enzymatic saccharification of pretreated sunflower stalks 显示文摘 | Sharma Sanjeev K Kalra Krishan L Grewal Harmeet S | 2002 | Biomass and Bioenergy2002，23，3： | 1 |
| 8 | Functional outcome of computer-assisted spinal pedicle screw placement:a systematic review and meta-analysis of 23 studies including 5,992 pedicle screws显示文摘 | Verma R Krishan S Haendlmayer K | | 0，，03： | 1 |
| 9 | Multifunctional facets of retrovirus integrase显示文摘The retrovirus integrase(IN) is responsible for integration of the reverse transcribed linear c DNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends. IN utilizes the 3' OH ends to catalyze the concerted integration of the two ends into opposite strands of the cellular DNA producing 4 to 6 bp staggered insertions, depending on the retrovirus species. The staggered ends are repaired by host cell machinery that results in a permanent copy of the viral DNA in the cellular genome. Besides integration, IN performs other functions in the replication cycle of several studied retroviruses. The proper organization of IN within the viral internal core is essential for the correct maturation of the virus. IN plays a major role in reverse transcription by interacting directly with the reverse transcriptase and by binding to the viral capsid protein and a cellular protein. Recruitment of several other host proteins into the viral particle are also promoted by IN. IN assists with the nuclear transport of the preintegration complex across the nuclear membrane. With several retroviruses, IN specifically interacts with different host protein factors that guide the preintegration complex to preferentially integrate the viral genome into specific regions of the host chromosomal target. Human gene therapy using retrovirus vectors is directly affected by the interactions of IN with these host factors. Inhibitors directed against the human immunodeficiency virus(HIV) IN bind within the active site of IN containing viral DNA ends thus preventing integration and subsequent HIV/AIDS. | Duane P Grandgenett Krishan K Pandey Sibes Bera Hideki Aihara | 2015 | World Journal of Biological Chemistry2015，6，3： | 1 |
| 10 | Chemical structure and physical properties of diamond-like amorphous carbon films prepared by magnetron sputtering显示文摘 | Cho N H Krishan K M Hopper C B | 1990 | J Mater Res1990，5，11： | 1 |
| 11 | Thermal Studies of6CSubstituted Cellulose and Its Subsequent Phosphorylated Products in Air 显示文摘 | LAC KRISHAN BHATNAGAR HARI L | 1986 | Thermachimica Acta1986，97，： | 1 |
| 12 | Thermal studies of C - 6 substituted cellulose and its subsequent phosphorylated products in air显示文摘 | JAIN RAJESH K LAC KRISHAN BHATNAGAR HARI L | 1986 | Thermachimica Acta1986，97，： | 1 |
| 13 | Thermal studies of C-6 substituted cellulose and its subsequent phosphorylated products in air 显示文摘 | JAIN RAJ ESH K LAC KRISHAN BHATNAGAR HARI L | 1986 | Thermachimica Acta1986，，97： | 1 |
| 14 | Establishing correlation of footprints with body weight - Forensic aspects 显示文摘 | Krishan K | 2008 | Forensic Science Int2008，179，： | 1 |
| 15 | Space conditioning using evaporative cooling for summers in Delhi显示文摘 | Krishan K Ashvini K Mullick S C | 2001 | Building and Environment2001，36，： | 1 |
| 16 | cDermo-1 misexpression induces dense dermis,feathers,and scales显示文摘 | Krishan K Yusuf F | 2005 | Dev Biol2005，277，： | 1 |
| 17 | Structure of One Neutron Halo Light Nuclei 11Be and 19O 显示文摘 | Bhattacharya R Krishan K | 1997 | Phys Rev C1997，56，： | 1 |
| 18 | Functional outcome of computer-assisted spinal pedicle serew placement:asystematic review and meta-analysis of 23studies including 5992 pedicle serew显示文摘 | Verma R Krishan S Headlmayer K etal | 2010 | Eur Spine J2010，19，： | 1 |
| 19 | Colloidal Nanocrystal Shape and Size Control: the Case of Cobalt 显示文摘 | Puntes V F Krishan K M Alivisatos A P | 2001 | Science2001，291，5511： | 1 |
| 20 | Functional outcome of computer-assisted spinal pedicle screw placement:a systematic review and meta-analysis of 23 studies including 5,992 pedicle screws显示文摘 | Verma R Krishan S Haendlmayer K | | 0，，03： | 1 |
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