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| 1 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
| 2 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 3 | Foamed crosslinked LDPE/PP blends made by hot mold injection molding显示文摘 | Touleshkov N Christova D | 2002 | Macromolecular Symposia2002，181，1： | 1 |
| 4 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 5 | Strength, deformation and relax- ation of joints bonded with modified eyanoacrylate adhesives显示文摘 | Petrov C Serafimov B Kotzev D L | 1988 | Int J Adhe~1988，8，1： | 1 |
| 6 | Studies of mechanical properties and melting behaviour of foamed and crosslinked LDPE/PP blends显示文摘 | G Kotzev | 2002 | Cellular Polymers2002，21，6： | 1 |
| 7 | Studies of mechanical properties and melting behaviour of foamed and crosslinked LDPE/PP blends显示文摘 | G Kotzev | 2002 | Cellular Polymers2002，21，6： | 1 |
| 8 | Prevalence of vitamin D deficiency and insufficiency in Bulgarian patients with chronic Hepatitis C viral infection显示文摘 | Daniela Ivanova Gerova Bistra Tzaneva Galunska Irina Ivanova Ivanova Iskren Andreev Kotzev Trifon Georgiev Tchervenkov Svetlozar Petrov Balev Dobrin Avramov Svinarov | 2014 | Scandinavian Journal of Clinical & Laboratory Investigation2014，，8： | 1 |
| 9 | Non-isocyanate-based polyu rethanes derived upon the reaction of amines with eyclocar bonate resins显示文摘 | Diakoumakos D C Kotzev L D | 2004 | Macromolecular Symposia2004，216，1： | 1 |
| 10 | Non-isocyanate basod polyurethanes derived upon the reaction of amines with cycloearbonate resins显示文摘 | DIAKOUMAKOS C D KOTZEV O L | 2004 | Macromolecular Symposia2004，216，： | 1 |
| 11 | A New Cationic Polymerizable Surfactant Bearing A Vinylamide Moiety显示文摘 | Kotzev A Laschewsky A | 2001 | Tenside Surfactants Detergents2001，38，3： | 1 |
| 12 | Risk and protective factors for development of colorectal polyps and cancer (Bulgarian experience)显示文摘 | Kotzev I Mirchev M Manevska B | 2008 | Hepatogastroenterology2008，55，8283： | 1 |
| 13 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 14 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 15 | Non-Isocyanate Based Pol- yurethanes Derived upon the Reaction of Amines with Cy- clecarbonate Resins 显示文摘 | Diakoumakos C D Kotzev D L | 2004 | Macromolecular Symposia2004，216，1： | 1 |
| 16 | Polyurethanes derived upon the reaction of amines with cyclocarbonate resins显示文摘 | C D Diakoumakos D L Kotzev | | 0，，： | 1 |
| 17 | Studies ofmechanical properties and melting behaviors of foamed and crosslinked LDPE/PP blends 显示文摘 | George Kotzev | 2002 | Cellular Polymers2002，21，6： | 1 |
| 18 | Foamed erosslinked LOPE /PP blends made by hot mold injection molding 显示文摘 | George Kotzev NikolaTouleshkov Denka Christova | 2002 | M acromolecular Symposia2002，181，1： | 1 |
| 19 | Risk and protective factors for development of colorectal polyps and cancer (Bulgarianexperience) 显示文摘 | Kotzev IM Manevska B | 2008 | Hepatogastroenterology2008，55，： | 1 |
| 20 | Foamed crosslinked LDPE/PP blends made by hot mold injection molding显示文摘 | George Kotzev Nikola Touleshkov Denka Christova | 2002 | Macromolecular Symposia2002，181，1： | 1 |
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