|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 3 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 4 | Carotid stenosis:fac-tors affecting symptomatology显示文摘 | Liapis C D Kakisis J D Kostakis A G | 2001 | Stroke2001，32，12： | 1 |
| 5 | Carotid Stenosis:Factors affecting symptomatology显示文摘 | LIPIAS C D KAKISIS J D KOSTAKIS A G | 2001 | Stroke2001，32，： | 1 |
| 6 | The role of cal-protectin in pediatric disease显示文摘 | RVAOS G KOSTAKIS I D ZAVRAS N | 2013 | Biomed Res Int2013，2013，54： | 1 |
| 7 | Severe odontogenic infections: causes of spread and their management 显示文摘 | Igoumenakis D Gkinis G Kostakis G | 2014 | Surg Infect(Larchmt)2014，15，1： | 1 |
| 8 | Longitudinal leueonyehia striata: is it a common sign in Hailey-Hailey and Darier disease? 显示文摘 | Kostaki D Castillo JC Ruzieka T | 2014 | J Eur Aead Dermatol Venere- ol2014，28，1： | 1 |
| 9 | Carotid stenosis:factors affecting symptomatology显示文摘 | Liapis C D Kakisis J D Kostakis A G | 2001 | Stroke2001，32，12： | 1 |
| 10 | RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow,and giant cell tumors of bone显示文摘 | Atkins G J Kostakis P Vincent C Farrugia A N Houchins J P Findlay D M | 2006 | J Bone Miner Res2006，21，： | 1 |
| 11 | Comparison of ery- thropoietin and sildenafil protective role against ischemi- a/reperfusion injury of the testis in adult rats显示文摘 | Zavras N Kostakis I D Sakellariou S | 2014 | Int Urol Nephrol2014，46，4： | 1 |
| 12 | Colorectal cancer stem cells显示文摘 | VAIOPOULOS A G KOSTAKIS I D KOUTSIUERIS M | 2012 | Stem Cells2012，30，3： | 1 |
| 13 | Population drug use in Australia: a wastewater analysis显示文摘 | Irvine R J Kostakis C Felgate P D | 2011 | Forensic Science International2011，210，13： | 1 |
| 14 | Carotid stenosis:factors affecting symptomatology显示文摘 | Liapis C D Kakisis J D Kostakis A G | 2001 | Stroke2001，32，12： | 1 |
| 15 | Predictive significance ofpreoperative serum VEGF - C and VEGF - D,independently andcombined with Cal9 - 9, for the presence of malignancy and lymphnode metastasis in patients with gastric cancer显示文摘 | Tsirlis T D’Kostakis A Papastratis G | 2010 | J Surg Oncol2010，102，6： | 1 |
| 16 | Photodynamic therapy for the treatment of micro invasive squamous cell carcinoma of the lower lip : a case report显示文摘 | Farguoli MC Kostaki D Piccioni A | 2014 | G Ital Dermatol Venereo12014，15，6： | 1 |
| 17 | Carotid stenosis:factors affecting symptomatology显示文摘 | Liapis C D Kakisis J D Kostakis A G | | 0，，14： | 1 |
| 18 | Carotid stenosis:factors affecting symptomatology显示文摘 | Liapis C D Kakisis J D Kostakis A G | 2001 | Stroke2001，32，12： | 1 |
| 19 | Predictive significance of preoperative serum VEGF-C and VEGFD,independently and combined with Ca19-9,for the presence of malignancy and lymph node metastasis in patients with gastric cancer显示文摘 | Tsirlis T D Kostakis A Papastratis G | | 0，，06： | 1 |
| 20 | Dermoscopy in the diagnosis and management of non-melanoma skin cancers显示文摘 | Fargnoli MC Kostaki D Piccioni A | 2012 | Eur J Dennatol2012，22，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员