|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients显示文摘AIM: To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. METHODS: Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 (MEN 1) and Zollinger-Ellison syndrome (ZES) underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors (NETs) between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test (SASI test) with secretin or calcium solution was performed as well as somatostatin receptor scintigraphy (SRS) and other imaging methods such as computed tomography (CT) or magnetic resonance imaging (MRI). The modus of surgery for gastrinoma has been changed over time, searching for the optimal surgery: pancreaticoduodenectomy (PD) was first performed guided by localization with the SAST test, then local resection of duodenal gastrinomas with dissection of regional lymph nodes (LR), and recently pancreas-preserving total duodenectomy (PPTD) has been performed for multiple duodenal gastrinomas. RESULTS: Among various types of preoperative localizing methods for gastrinoma, the SASI test was the most useful method. Imaging methods such as SRS or CT made it essentially impossible to differentiate functioning gastrinoma among various kinds of NETs. However, recent imaging methods including SRS or CT were useful for detecting both distant metastases and ectopic NETs; therefore they are indispensable for staging of NETs. Biochemical cure of gastrinoma was achieved in 14 of 16 patients (87.5%); that is, 100% in 3 patients who underwent PD, 100% in 6 patients who underwent LR (although in 2 patients (33.3%) second LR was performed for recurrence of duodenal gastrinoma), and 71.4% in 7 patients who underwent PPTD. Pancreatic NETs more than 1 cm in diameter were resected either by distal pancreatectomy or enucleations, and no hepatic metastases have developed postoperatively. Pathological study of the resected specimens revealed co-existence of pancreatic gastrinoma with duodenal gastrinoma in 2 of 16 patients (13%), and G cell hyperplasia and/or microgastrinoma in the duodenal Brunner's gland was revealed in all of 7 duodenal specimens after PPTD. CONCLUSION: Aggressive resection surgery based on accurate localization with the SASI test was useful for biochemical cure of gastrinoma in patients with MEN 1. | Masayuki Imamura Izumi Komoto Shuichi Ota Takuya Hiratsuka Shinji Kosugi Ryuichiro Doi Masaaki Awane Naoya Inoue | 2011 | World Journal of Gastroenterology2011，17，10： | 5 |
| 2 | Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan显示文摘 | Tetsuhide Ito Hironobu Sasano Masao Tanaka R. Yoshiyuki Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Kazuhiko Nakamura Hisato Igarashi Rober | 2010 | Journal of Gastroenterology2010，，2： | 4 |
| 3 | Catalytic FriedelCrafts acylation of aniline derivatives显示文摘 | Kobayashi S Komoto I Matsuo J I | 2001 | Advanced Synthesis &Catalysis2001，343，1： | 1 |
| 4 | A comparative study on cost and life-cycle analysis for 100MW very large-scale (VLS-PV)systems in deserts u-sing m-si,a-si CdTe and CIS modules显示文摘 | Ito M Kato K Komoto K Kichimi T Kurokava K | | 0，，： | 1 |
| 5 | In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer显示文摘 | Komoto M Nakata B Nishii T | 2010 | Cancer Sci2010，101，2： | 1 |
| 6 | Effect of arbutin on melanogenic proteins in human melanocytes显示文摘 | CHAKRABORTY A K FUNASAKA Y KOMOTO M | 1998 | Pigment Cell Res1998，11，4： | 1 |
| 7 | A framework for computer- aided conceptual design and its application to system architec- ting of mechatronics products显示文摘 | KOMOTO H TOMIYAMA T | 2012 | Computer-Aided Design2012，44，10： | 1 |
| 8 | Helicobacter pylori in- fection is the major risk factor for atrophic gastritis 显示文摘 | Kawaguchi H Haruma K Komoto K | 1996 | Am J Gas- troenterol1996，91，5： | 1 |
| 9 | Pancreatic Endocrine Tu in Japan显示文摘 | Doi R Komoto I Nakamura Y | 2004 | P2004，28，3： | 1 |
| 10 | Effect of arbutin on melanogenic proteins in human melanocytes显示文摘 | CHAKRABORTY A K FUNASAKA Y KOMOTO M | 1998 | Pigment Cell Res1998，11，4： | 1 |
| 11 | A system architecting tool for mecha-tronic systems design显示文摘 | Komoto H Tomiyama T | 2010 | CIRP Annals - Manufacturing Tech-nology2010，59，1： | 1 |
| 12 | Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosorne marker 显示文摘 | Hanaki K Momo A Oku T Komoto A Maenosono S Yamagu- ehi Y | 2003 | Biochem Biophys Res Commun2003，302，3： | 1 |
| 13 | MDR1 T-129C polymor- phism can be predictive of differentiation, and thereby prognosis of coloreetal adenocarcinomas in Japanese 显示文摘 | Koyama T Nakamura T Komoto C | 2006 | Biol Pharm Bull2006，29，7： | 1 |
| 14 | Relationship between solid- state molecular' motion and morphology for ultrahigh molecular weight polyethylene crystallized under different conditions 显示文摘 | Uehara H Yamanobe T Komoto T | 2000 | Macromolecules2000，33，： | 1 |
| 15 | Apical hypertrophy with massive myocardial fibrosis: comparison with electrocardiographic changes显示文摘 | Fujimoto S Komoto Y Sakaguchi Y | 1998 | Intern Med1998，37，： | 1 |
| 16 | Prevalence of serum celiac antibody in patients with IBD in Japan 显示文摘 | Watanabe C Komoto S Hokari R | 2013 | J Gastroenterol2013，，： | 1 |
| 17 | Prospective study of non-closure or closure of the peritoneum at cesarean delivery in 124 women:Impact of prior peritoneal closure at primary cesarean on the interval time between first cesarean section and the next pregnancy and significant adhesion at second cesarean显示文摘 | Komoto Y Shimoya K Shimizu T | 2006 | J Obstet Gynaecol Res2006，32，4： | 1 |
| 18 | Crystal structure of S-adenosylhomocysteine hydrolase from rat liver显示文摘 | Hu Y Komoto J Huang Y | 1999 | Biochemistry1999，38，26： | 1 |
| 19 | Experimental study of alleviation of hypertension, diabetes and pain by radon inhalation 显示文摘 | Yamaoka K Komoto Y | 1996 | Physiol Chem Phys Med NMR1996，28，1： | 1 |
| 20 | A re- view of funetion modeling: approaches and applications 显示文摘 | ERDENMS KOMOTO H VAN BEEK T J | 2008 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2008，22，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员