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| 1 | Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel. | Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth | 2010 | World Journal of Cardiology2010，2，7： | 36 |
| 2 | Diverse Roles of Strigolactones in Plant Development显示文摘与根流出物表明那的 strigolactones 的发现触发寄生杂草种子萌芽,然后作为一个分叉的禁止者和植物荷尔蒙, strigolactone 研究的下一个阶段快速在优化植物生长和开发作为一个主要播放器揭示了这个荷尔蒙类。从植物进化的早阶段,看起来, strigolactones 涉及创新植物修改生长以便为有限资源与附近的有机体在竞争获得优点。例如,苔藓植物能响应从一位邻居发出的 strigolactones 改变它的生长。在更高的植物以内, strigolactones 看起来涉及经由生长和开发的战略修正控制资源分发的平衡。最尤其是,更高种那相遇磷酸盐缺乏增加 strigolactone 生产,它改变根生长并且支持真菌的共生提高磷酸盐吸入。射击也由 channeling 资源变化离开非本质的叶子和分支并且进主要的茎和根系统。这神经质的回答是极端地改变整个植物的建筑学以便在多样的环境条件下面优化生长和开发的关键改编。 | Philip B. Brewer Hinanit Koltai Christine A. Beveridget | 2013 | Molecular Plant2013，6，1： | 30 |
| 3 | The complex relationship between multiple drug resistance and the tumor pH gradient:a review显示文摘Multiple drug resistance(MDR)is the tumor’s way of escaping the cytotoxic effects of various unrelated chemotherapeutic drugs.It can be either innate or acquired.MDR represents the end of the therapeutic pathway,and it practically leaves no treatment alternatives.Reversing MDR is an unfulfilled goal,despite the important recent advances in cancer research.MDR,the main cause of death in cancer patients,is a multi-factorial development,and most of its known causes have been thoroughly discussed in the literature.However,there is one aspect that has not received adequate consideration-intracellular alkalosis-which is part of wider pH deregulation where the pH gradient is inverted,meaning that extracellular pH is decreased and intracellular pH increased.This situation interacts with MDR and with the proteins involved,such as P-gp,breast cancer resistance protein,and multidrug associated resistance protein 1.However,there are also situations in which these proteins play no role at all,and where pH takes the lead.This is the case in ion trapping.Reversing the pH gradient to normal can be an important contribution to managing MDR.The drugs to manipulate pH exist,and most of them are FDA approved and in clinical use for other purposes.Furthermore,they have low or no toxicity and are inexpensive compared with any chemotherapeutic treatment.Repurposing these drugs and combining them in a reasonable fashion is one of the points proposed in this paper,which discusses the relationship between cancer’s peculiar pH and MDR. | Tomas Koltai | 2022 | Cancer Drug Resistance2022，5，2： | 2 |
| 4 | 体育运动与活性氧对大脑的复杂作用显示文摘活性氧(ROS)在有氧代谢中以中度水平持续产生,有利于产生氧化还原信号,但数量较大时却能引起氧化损伤和神经退行性病变。由于大脑对ROS敏感度提高,在不同类型神经细胞中保持正常氧化还原状态尤为重要。过去10年的研究充分说明:有规律的运动对大脑功能产生有益影响,并对中风、老年痴呆和帕金森症的预防和治疗起重要作用。然而,研究运动的具体影响似乎又非常复杂,包括通过神经营养因子的神经发生、毛细血管化增加、氧化损伤减少,以及通过蛋白酶和脑啡肽酶的蛋白降解增加。来自我们及其他实验室的数据表明,运动诱导的ROS水平调节对蛋白含量以及脑源性神经营养因子(BDNF)、酪氨酸激酶B(TrkB)、cAMP反应元件结合蛋白(CREB)的表达有重要作用,有利于完善脑功能、增加神经生成。因此,运动诱导的氧化还原状态调节是一种重要方式,运动能通过这一方式造福于大脑功能、增强对氧化应激的抵抗力,协助从氧化应激中恢复、减弱年龄相关的认知能力下降。 | Zsolt Radak Orsolya Marton Eniko Nagy Erika Koltai Sataro Goto | 2013 | Journal of Sport and Health Science2013，2，2： | 2 |
| 5 | Structure-Function Relations of Strigolactone Analogs: Activity as Plant Hormones and Plant Interactions显示文摘Strigolactones (SL ) 作为在他们和共生 arbuscular mycorrhizal (AM ) 的相互作用表明分子有几功能真菌和寄生杂草 Orobanche 和 Striga。SL 也是调整植物开发的植物荷尔蒙的一个新类。在所有三个有机体,一个特定、敏感的调停受体的感觉系统被建议。由在 Arabidopsis 根头发延伸, Orobanche aegyptiaca 种子萌芽,并且 AM 真菌血管球 intraradices 的菌丝的分叉上比较合成 SL 类似物的活动,我们发现每测试有机体在它对各种各样的检验合成 SL 类似物的反应不同。SL 类似物的 Structurefunction 关系作为这个变化的原因在 A-ring 上建议替换。而且,对竞争对抗类似物的描述建议 SL 的 A-ring 能影响不仅亲密关系到受体,而且激活它的分子能力。结果支持 Arabidopsis, Orobanche,和 AM 真菌在受体敏感拥有变化到 SL 类似物的结论,可能由于在在不同种类之中的 SL 受体的变化。 | Maja Cohen Cristina Prandi Ernesto G. Occhiato Silvia Tabasso Smadar Wininger Nathalie Resnick Yosef Steinberger Hinanit Koltai Yoram Kapulnik | 2013 | Molecular Plant2013，6，1： | 2 |
| 6 | Power-assisted adenoidectomy显示文摘 | KOLTAI PJ KALATHIA AS STANISLAW P | 1997 | Arch Otolaryngol Head Neck Surg1997，123，： | 1 |
| 7 | Hemorheological pa-rameters and aging显示文摘 | Feher G Koltai K Kesmarky G | | 0，，： | 1 |
| 8 | Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training显示文摘 | Koltai E Hart N Taylor A | | 0，，02： | 1 |
| 9 | The Effect of Aspirin on Hemorheological Parameters of Patients with Diabetic Retinopathy显示文摘 | Vekasi J koltai K Gaal V | 2008 | Clinical Hemorheology and Microcirculation2008，39，： | 1 |
| 10 | PAF:A review of its effects,antagonists and possible future clinical implications(part2)显示文摘 | Hosford D Guinot P | 1989 | Eur J Pharmacol1989，164，2： | 1 |
| 11 | Are hemorheological parameters independent of aging Clin Hemorheol Microcirc显示文摘 | Feher G Koltai K Toth K | 2007 | 2007，，： | 1 |
| 12 | New strategies forthe control of plant-parasitic nematodes显示文摘 | Oka Y Koltai H Bar-Eyal M | 2000 | PestManagement Science2000，56，： | 1 |
| 13 | Comparative inhibiting effect of polycondensed aromatics and nitrogen compounds on the hydrodesulfurization of alkyldibenzothiophenes显示文摘 | KOLTAI T MACAUDA M GUEVARA A | 2002 | Applied Catalysis A:General2002，232，2： | 1 |
| 14 | Intracapsular tonsillar reduction(partial tonsillectomy),Revi-ving a historical procedure for obstructive sleep disordered breath-ing in children显示文摘 | KOLTAI Peter J SOLARES C Arturo KOEMPEL Jeffery A etal | 2003 | Otolaryngology and head and neck surgery2003，129，5： | 1 |
| 15 | Synthesis of ^14C labelled drotaverine hydrochloride显示文摘 | Koltai E Banfi D Engler J | 1979 | J Label Compd Radiopharm1979，16，2： | 1 |
| 16 | Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age- associated DNA damage 显示文摘 | Koltai E Zhao Z Lacza Z | 2011 | Rejuvenation Res2011，14，6： | 1 |
| 17 | Transcriptional profiling of high pigment-2dg tomato mutant links early fruit plastid biogenesis with its overproduction of phytonutrients显示文摘 | KOLOTILIN I KOLTAI H TADMOR Y | 2007 | Plant Physiology2007，145，2： | 1 |
| 18 | Operative management of juvenileonset recurrent respiratory papillomatosis显示文摘 | Hoff SR Koltai PJ | 2012 | Oper Tech Otolaryngol2012，23，： | 1 |
| 19 | A review of its effects, antagonists and possible future clinical implications (Part Ⅱ) 显示文摘 | Koltai M Hosford D Guinot P | 1991 | Drugs1991，42，2： | 1 |
| 20 | Exercise, oxidative stress and hormesis 显示文摘 | Radak Z Chung H Y Koltai E | 2008 | Ageing Research Reviews2008，7，1： | 1 |
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