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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis显示文摘 | Lutchman G Modi A Kleiner DE | 2007 | Hepatology2007，46，2： | 1 |
| 3 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 4 | End points and clini- cal trial design for nonalcoholic steatohepatitis显示文摘 | Sanyal A J Brunt EM Kleiner DE | 2011 | Hepatolo- gy2011，54，1： | 1 |
| 5 | Real-time localization and ele- vation mapping within urban search and rescue scenarios 显示文摘 | Kleiner A Dornhege C | 2007 | Journal of Field Robotics2007，24，89： | 1 |
| 6 | The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis显示文摘 | Lutchman G Modi A Kleiner DE | 2007 | Hepatoplogy2007，46，： | 1 |
| 7 | Formation of helicalbeams by use of Pancharatnam-Berry phase optical ele- ments 显示文摘 | Biener G Niv A Kleiner V | 2002 | Optics Letters2002，27，21： | 1 |
| 8 | Manufacturing of Light weight Components by Metal Forming 显示文摘 | KLEINER M GEIGER M KLAUS A | 2003 | Annals of the CIRP2003，52，2： | 1 |
| 9 | Microstructures and mechanical properties of squeeze cast and semi-solid cast Mg-Al alloys 显示文摘 | Kleiner S Beffort O Wahlen A | 2002 | Journal of Light Metals2002，2，4： | 1 |
| 10 | Spiral phase elements obtained by use of discrete space-variant subwavelentgh gratings显示文摘 | Niv A Biener G Kleiner V | 2005 | Opt Commun2005，251，： | 1 |
| 11 | 查看详情显示文摘 | Zakirov M I Kleiner V I Adrov O I Nifantev I E Shklyaruk B F Stroganov V S Nedorezova P M Klyamkina A N | | 0，，9： | 1 |
| 12 | Computer-generate dinfrared depolarzer using space-variant sub wavelength dielectric gratings 显示文摘 | BIENER C NIV A KLEINER V | 2003 | J O S A2003，28，16： | 1 |
| 13 | Manufacturing oflightweight components by metal forming显示文摘 | KLEINER M GEIGER M KLAUS A | 2003 | Annals ofthe CIRP2003，52，： | 1 |
| 14 | The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis 显示文摘 | Lutchman G Modi A Kleiner DE | 2007 | Hepatology2007，46，2： | 1 |
| 15 | Manufacturing of light- weight components by metal forming显示文摘 | KLEINER M GEIGER M KLAUS A | 2003 | CIRP Annals Manu- facturing Technology2003，52，2： | 1 |
| 16 | Determination of flow curves at high strain rates using the electromagnetic forming process and an iterative finite element simulation scheme显示文摘 | BEERWALD C KLEINER M | 2003 | Journal De Physique2003，110，4： | 1 |
| 17 | Validation of a model of colon cancer progression显示文摘 | Hewitt RE Mc Marlin A Kleiner D | 2000 | J Pathol2000，192，4： | 1 |
| 18 | Stability analysis of latent and active 72 - kDa type Ⅳ collagenase: the role of tissue inhabitor of metalloproteinase-2 ( timp - 2 ) 显示文摘 | Kleiner DE Tuuttila A Karl T | 1993 | Biochemistry1993，32，6： | 1 |
| 19 | On the relationship between web services security and traditional protocols显示文摘 | Kleiner E Roscoe A W | 2006 | Elec- tronic Notes in Theoretical Computer Science2006，155，1： | 1 |
| 20 | Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3显示文摘 | Cramer A Kleiner S Westermann M | 2005 | J Cell Biochem2005，95，4： | 1 |
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