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| 1 | Eight-year survival after advanced gastric cancer treated with S-1 followed by surgery显示文摘We report a case of advanced gastric cancer, with cervical, axillary, and abdominal paraaortic lymph node metastases, that was successfully treated with chemotherapy and surgery. The disease was initially considered unresectable, and the patient was treated with orally administered S-1. Chemotherapy was effective, and all lymph node metastases disappeared after 6 courses. After 27 mo of chemotherapy, the patient underwent curative surgery, with subtotal gastrectomy and lymph node dissection. Histopathological examination revealed many viable poorly differentiated adenocarcinoma cells in the stomach, but no cancer cells in the lymph nodes. The patient is alive, without recurrence, 8 years later. This, therefore, is a case report of an 8-year survivor of advanced gastric cancer with distant lymph node metastasis. | Susumu Hijioka Keisho Chin Yasuyuki Seto Noriko Yamamoto Kiyohiko Hatake | 2010 | World Journal of Gastroenterology2010，16，22： | 10 |
| 2 | Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer显示文摘Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer(CRC),and the importance of angiogenesis in cancer progression has been established.Computed tomography(CT)perfusion(CTP)based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics.CTP has been reported to characterize tumor angiogenesis,and to be a sensitive marker for predicting recurrence or survival in CRC.In this review,we will discuss the biomarker value of CTP in the management of CRC patients. | Koichi Hayano Takeshi Fujishiro Dushyant V Sahani Asami Satoh Tomoyoshi Aoyagi Gaku Ohira Toru Tochigi Hisahiro Matsubara Kiyohiko Shuto | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 3 | Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women显示文摘 | Shunji Fujimori Teruyuki Kishida Tsuyoshi Kobayashi Yoshihisa Sekita Tsuguhiko Seo Kazuhiro Nagata Atsushi Tatsuguchi Katya Gudis Kimiyoshi Yokoi Noritake Tanaka Kiyohiko Yamashita Takashi Tajiri Yoshiharu Ohaki Choitsu Sakamoto | 2005 | Journal of Gastroenterology2005，，9： | 2 |
| 4 | 为与窒息肠塞痛联系的肠的局部缺血的察觉的动态 CT 的动脉的阶段的用途显示文摘 AIM:To clarify the usefulness of arterial phase scans in contrast computed tomography (CT) imaging of stran-gulation ileus in order to make an early diagnosis. METHODS:A comparative examination was carried out with respect to the CT value of the intestinal tract wall in each scanning phase, the CT value of the content in the intestinal tract, and the CT value of ascites fluid in the portal vein phase for a group in which ischemia was observed (Group Ⅰ) and a group in which ischemia was not observed (Group N) based on the pathological findings or intra-surgical findings. Moreover, a comparative examination was carried out in Group Ⅰ subjects for each scanning phase with respect to average differences in the CT values of the intestinal tract wall where ischemia was suspected and in the intestinal tract wall in non-ischemic areas. RESULTS:There were 15 subjects in Group Ⅰ and 30 subjects in Group N. The CT value of the intestinal tract wall was 41.8 ± 11.2 Hounsfield Unit (HU) in Group Ⅰ and 69.6 ± 18.4 HU in Group N in the arterial phase, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ. In the portal vein phase, the CT value of the ischemic bowel wall was 60.6 ± 14.6 HU in Group Ⅰ and 80.7 ± 17.7 HU in Group N, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ; however, no significant differences were observed in the equilibrium phase. The CT value of the solution in the intestine was 18.6 ± 9.5 HU in Group Ⅰ and 10.4 ± 5.1 HU in Group N, being signifi-cantly higher in Group Ⅰ. No significant differences were observed in the CT value of the accumulation of ascites fluid. The average difference in the CT values between the ischemic bowel wall and the non-ischemic bowel wall for each subject in Group Ⅰ was 33.7 ± 20.1 HU in the arterial phase, being significantly larger compared to the other two phases. CONCLUSION:This is a retrospective study using a small number of subjects; however, it suggests that there is a possibility that CT scanning in the arterial phase is useful for the early diagnosis of strangulation ileus. | Gaku Ohira Kiyohiko Shuto Tsuguaki Kono Takayuki Tohma Hisashi Gunji Kazuo Narushima Shunsuke Imanishi Takeshi Fujishiro Tohru Tochigi Toshiharu Hanaoka Hideaki Miyauchi Naoyuki Hanari Hisahiro Matsubara Noriyuki Yanagawa | 2012 | World Journal of Radiology2012，4，11： | 2 |
| 5 | Imaging biomarkers for the treatment of esophageal cancer显示文摘Esophageal cancer is known as one of the malignant cancers with poor prognosis.To improve the outcome,combined multimodality treatment is attempted.On the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”medicine.Recent advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer treatment.In this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer. | Koichi Hayano Gaku Ohira Atsushi Hirata Tomoyoshi Aoyagi Shunsuke Imanishi Toru Tochigi Toshiharu Hanaoka Kiyohiko Shuto Hisahiro Matsubara | 2019 | World Journal of Gastroenterology2019，25，24： | 2 |
| 6 | Characterization of a Chitosanase from Aspergillus fumigatus ATCC13073 显示文摘 | Katsuaki Hirano Sitthinan Arayaveerasid Kiyohiko Seki | 2012 | Bioscience Biotechnology and Biochemistry2012，76，8： | 1 |
| 7 | Genetic relationship between lipid content and linolenic acid concentration in soybean seeds显示文摘 | Masayuki S kiyohiko T Aya U | 2008 | Breeding Science2008，58，： | 1 |
| 8 | Production of high-strength glass-ceramics from industrial wastes using phase equilibrium diagram of CaO-Al2O3-SiO2 system显示文摘 | Kiyohiko IKEDA Hiroyuki KINOSHITA Ryusuke KAWAMURA | | 0，，05： | 1 |
| 9 | Rotavirus infection among infants with diarrhea in Pakistan 显示文摘 | Osamu Nshio Kiyohiko Matsui Tomohiro Oka | 2000 | Pediatrics International2000，，42： | 1 |
| 10 | Document-sharing platform for a virtual enterprise: CoOrbiter 显示文摘 | Kajiwara Kiyohiko Kimura Akihiro | 1999 | NTTR and D1999，48，3： | 1 |
| 11 | In situ stress measurements in a borehole close to the Nojima fault显示文摘 | Hiroaki Tsukahara Ryuji Ikeda and Kiyohiko Yamamoto | 2001 | The island arc2001，10，： | 1 |
| 12 | Effects of temperature and inoculum on the degradability of poly(e-caprolactone)during compoating显示文摘 | Akihito Ohtaki Naoki Akakura Kiyohiko Nakasaki | 1998 | Polym Degrad Stab1998，62，1： | 1 |
| 13 | Coagulation processof soymilk characterized by electrical impedance spectroscopy 显示文摘 | Xingshu Li Kiyohiko Toyoda Ikko Ihara | 2011 | Journal of Food Engineering2011，105，3： | 1 |
| 14 | Rotavirus infection among infants with diarrhea in Pakistan显示文摘 | Osamu Nishio Kiyohiko Matsui Tomohiro Oka | 2000 | Pediatrics International2000，42，： | 1 |
| 15 | COBAS ? TaqMan ? MTB, smear positivity grade and MGIT culture; correlation analyses of three methods for bacillary quantification显示文摘 | Kinuyo Chikamatsu Akio Aono Tomoko Kato Akiko Takaki Hiroyuki Yamada Yuka Sasaki Kiyohiko Izumi Lina Yi Satoshi Mitarai | 2015 | Journal of Infection and Chemotherapy2015，，： | 1 |
| 16 | Characteristics of anaerobic ammonia removal by a mixed culture of hyrogen producing photosynthetic bacteria 显示文摘 | HIROO T KIYOHIKO S IN-BEOM K | 2004 | Bioresource Technology2004，95，2： | 1 |
| 17 | Perioperative Blood Transfusion as a Prognostic Indicator in Patients with Hepatocellular Carcinoma显示文摘 | Toshimasa Asahara Kouji Katayama Toshiyuki Itamoto Masatsugu Yano Hiroshi Hino Yuzo Okamoto Hideki Nakahara Kiyohiko Dohi Katsufumi Moriwaki Osafumi Yuge | 1999 | World Journal of Surgery1999，，7： | 1 |
| 18 | Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women显示文摘 | Shunji Fujimori Teruyuki Kishida Tsuyoshi Kobayashi Yoshihisa Sekita Tsuguhiko Seo Kazuhiro Nagata Atsushi Tatsuguchi Katya Gudis Kimiyoshi Yokoi Noritake Tanaka Kiyohiko Yamashita Takashi Tajiri Yoshiharu Ohaki Choitsu Sakamoto | 2005 | Journal of Gastroenterology2005，，9： | 1 |
| 19 | Reduced glial cell ling-derived neurotrophic factor lev el in aganglionic bowel in Hirschsprung's disease显示文摘 | Kiyohiko O Puri P | 1998 | J Pediatr Surg1998，3，6： | 1 |
| 20 | Isolated caudate lobectomy by anterior approach for hepatocellular carcinoma originating in the paracaval portion of the caudate lobe显示文摘 | Toshimasa Asahara Kiyohiko Dohi Hiroshi Hino Hideki Nakahara Kouji Katayama Toshiyuki Itamoto Eiji Ono Katsufumi Moriwaki Osafumi Yuge Toshio Nakanishi Mikiya Kitamoto | 1998 | Journal of Hepato - Biliary - Pancreatic Surgery1998，，4： | 1 |
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