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| 1 | Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease显示文摘Mitochondrial dysfunction is known to be a contributing factor to a number of diseases including chronic alcohol induced liver injury. While there is a detailed understanding of the metabolic pathways and proteins of the liver mitochondrion, little is known regarding how changes in the mitochondrial proteome may contribute to the development of hepatic pathologies. Emerging evidence indicates that reactive oxygen and nitrogen species disrupt mitochondrial function through post-translational modifications to the mitochondrial proteome. Indeed, various new affinity labeling reagents are available to test the hypothesis that post-translational modification of proteins by reactive species contributes to mitochondrial dysfunction and alcoholic fatty liver disease. Specialized proteomic techniques are also now available, which allow for identification of defects in the assembly of multi-protein complexes in mitochondria and the resolution of the highly hydrophobic proteins of the inner membrane. In this review knowledge gained from the study of changes to the mitochondrial proteome in alcoholic hepatotoxicity will be described and placed into a mechanistic framework to increase understanding of the role of mitochondrial dysfunction in liver disease. | Sudheer K Mantena Adrienne L King Kelly K Andringa Aimee Landar Victor Darley-Usmar Shannon M Bailey | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 2 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 3 | Prednisone,azathioprine,and N-acetylcysteine for pulmonary fibrosis显示文摘 | Raghu G Anstrom K J King TE Jr | | 0，，21： | 2 |
| 4 | Acute lung injury review 显示文摘 | Tsushima K King LS Aggarwal NR | 2009 | Intern Med2009，48，9： | 1 |
| 5 | Correlation of heavy-truck driver fatigue with vehicle-based control measures显示文摘 | SIEGMUND G P KING D J MUMFORD D K | 1995 | SAE Paper 9525941995，，： | 1 |
| 6 | On edge detection of X -ray images using fuzzy sets显示文摘 | PAL S K KING R A | 1983 | IEEE Trans Part Analand Machine Intell1983，5，1： | 1 |
| 7 | Zinc biosorption on Tectona grandis L leaves biomass:Equilibrium and kinetic studies显示文摘 | Kumar Y P King P Prasad V S R K | 2006 | Chemical Engineering Journal2006，124，1： | 1 |
| 8 | Retinal artery occlusion following intravitreal anti-VEGF therapy显示文摘 | von Hanno T Kinge B Fossen K | 2010 | Acta Ophthalmol2010，88，2： | 1 |
| 9 | Cell cycle and apoptosis:common pathways to life and death显示文摘 | King K L Cidlowski J A | 1995 | Cell Biochem1995，58，2： | 1 |
| 10 | Control of yeast mating signal transduction by a mammalian β2-Adrenergic receptor and Gsα subunit 显示文摘 | King K Dohlman HG Thorner J | 1990 | Science1990，250，： | 1 |
| 11 | Measurement of angular acceleration of a rigid body using linear accelerometers显示文摘 | Padgaonkar A J Kriege K W King A I | 1975 | Journal of Applied Mechanics (S0021-8936)1975，42，： | 1 |
| 12 | Image enhancement using smoothing with fuzzy sets显示文摘 | PAL S K KING R A | 1981 | IEEE Transactions on System Man and Cybermetics1981，11，7： | 1 |
| 13 | Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model 显示文摘 | KING G D MUHAMMAD A K CURTIN J F | 2008 | Neuro Oncol2008，10，1： | 1 |
| 14 | AACVPR/ACC/AHA2007 performance measures on cardiac rehabilitation for referral to and delivery of cardiac rehabilitation/secondary prevention services 显示文摘 | Thomas R J King M Lui K | 2007 | Circulation2007，116，14： | 1 |
| 15 | Prccipitation reactions in Magnesium-rate eaeth aIloys containing yttrium,gadolinium ordysprosium显示文摘 | Apps P J Karimzadeh H King J K | 2003 | Scripta Materialia2003，48，： | 1 |
| 16 | A rapid method for magnetic granulometry with applications to environmental studies显示文摘 | Banerjee S K King J Marvin J | | 0，，04： | 1 |
| 17 | Antecedents of knowledge trans- fer from consultants to clients in enterprise system implementations显示文摘 | Dong-Gil K Kitsch L J King W R | 2005 | MIS Quarterly2005，29，1： | 1 |
| 18 | Why positive psychology is necessary 显示文摘 | SHELIX)N K M KING L | 2001 | American psychologist2001，56，3： | 1 |
| 19 | Self-organization in a multicore fiber laser array显示文摘 | E J Bochove P K Cheo G G King | 2003 | Opt Lett2003，28，14： | 1 |
| 20 | Gibberellin regulates Arabidopsis seed germination via RGL2,a GAI/RGA-like gene whose expression is up-regulated following imbibition 显示文摘 | Lee S Cheng H King K E | 2002 | Genes Dev2002，16，： | 1 |
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