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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review显示文摘 | Colosia AD Palencia R Khan S | 2013 | Diabetes Metab Synch' Obes2013，6，02： | 1 |
| 3 | , a review 显示文摘 | Patil S B Khan M K Germinated brown rice as a value added rice product | 2011 | Journal of Food Science and Technology2011，48，6： | 1 |
| 4 | Gastrointestinal norovirus infection associated with exacerbation of inflammatory bowel disease显示文摘 | Khan RR Lawson AD Minnich LL etal | 2009 | J Pediatr Gastroenterol Nutr2009，48，3： | 1 |
| 5 | Current concepts in intervertebral disc restoration显示文摘 | Diwan AD Parvataneti HK Khan SN | | 0，，03： | 1 |
| 6 | Cerebral a- neurysm associated with an intracranial tumor: staged en- dovascular and surgical treatment in two cases显示文摘 | Javadpour M Khan AD Jenkinson MD | 2004 | Br J Neu- rosurg2004，18，3： | 1 |
| 7 | Current concepts in intervertebral disc restoration显示文摘 | Diwan AD Parvataneti HK Khan SN | 2000 | Orthop Clin North Am2000，31，： | 1 |
| 8 | Current concepts in intervertebral disc restoration显示文摘 | Diwan AD Parvataneni HK Khan SN | 2000 | Orthop Clin North Am2000，31，3： | 1 |
| 9 | Imaging of acute pulmonary em- boli显示文摘 | Khan A Cann AD Shah RD | 2004 | Thorac Surg Clin2004，14，： | 1 |
| 10 | Continuous low-dose cy- clophosphamide and methotrexate combined with celecoxib for pa- tients with advanced cancer显示文摘 | Khan OA Blann AD Payne MJ | 2011 | Br J Cancer2011，104，12： | 1 |
| 11 | Antibacterial activity of Artocarpus heterophyllus显示文摘 | Khan MR Omoloso AD Kihara M | 2003 | Fitotempia2003，74，5： | 1 |
| 12 | The molecular basis of intervertebral disk degeneration显示文摘 | Chung SA i Khan SN Diwan AD | 2003 | Orthop Clin North Am2003，4，2： | 1 |
| 13 | Current concepts in intervertebral disk resoration显示文摘 | Diwan AD Pavalaneni HK Khan SN | 2000 | Orthopedic Clinics of North America2000，31，： | 1 |
| 14 | Current concepts in intervertebral disc restoration 显示文摘 | Diwan AD Parvalaneni HK Khan SN | 2000 | Orthop Clin Nor Am2000，31，3： | 1 |
| 15 | Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies:a systematic literature review显示文摘 | Colosia AD Palencia R Khan S | 2013 | Diabetes Metab Syndr Obes2013，6，： | 1 |
| 16 | Current concept in intervertebral disc restoration显示文摘 | Diwan AD Parvataneti HK Khan SN el al | 2000 | Orthop Clin North Am2000，31，： | 1 |
| 17 | Anti microbial activity of Bi-dens pilosa, Bischofia javanica, Elmerillia papuana and Siges-bekiaorientalis显示文摘 | Khan MR Kihara M Omoloso AD | 2001 | Fitoterapia2001，72，6： | 1 |
| 18 | Current concepts in intervertebral disc restoration显示文摘 | Diwan AD Parvataneni HK Khan SN | 2003 | Orthop Ciin North Am2003，31，： | 1 |
| 19 | Accumulation dynamics and acute toxicity of silver nanoparticles to Daphnia magna and Lumbriculus variegatus: implications for metal modeling approaches 显示文摘 | Khan FR Paul KB Dybowska AD | 2015 | Environ Sci Technol2015，49，7： | 1 |
| 20 | Current concepts in intervertebral disk restoration 显示文摘 | Diwan AD Parvataneni HK Khan SN | 2000 | Orthop Clin North Am2000，31，3： | 1 |
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