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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | The genotoxic and cytotoxic activities of inorganic fluoride in cultured rat bone marrow cells 显示文摘 | Khalil AM Da'dara AA | 1994 | Arch Environ Contam Toxicol1994，26，1： | 1 |
| 3 | Renal stone disease and obesity: what is important for urologists and nephrologists 显示文摘 | Ahmed MH Ahmed HT Khalil AA | 2012 | Renal Failure2012，34，10： | 1 |
| 4 | The submental flap for oral cavity reconstruction: extended indications and technical refinements 显示文摘 | Amin AA Sakkary MA Khalil AA | 2011 | Head Neck Oncol2011，3，1： | 1 |
| 5 | Heat shock proteins in on- cology: Diagnostic biomarkers or therapeutic targets? 显示文摘 | Khalil AA Kabapy NF Deraz SF | 2011 | Bio-chim Biophys Acta2011，16，2： | 1 |
| 6 | The submental flap for oral cavity reconstruction:extended indications and technical refinements显示文摘 | Amin AA Sakkary MA Khalil AA | 2011 | Head Neck Oncol2011，3，： | 1 |
| 7 | Heat shock pro- teins in oncology:diagnostic biomarkers or therapeutic targets显示文摘 | Khalil AA Kabapy NF Deraz SF | 2011 | Biochem Biophys Acta2011，1816，2： | 1 |
| 8 | The submental flap for oral cavity reconstruction:extended indications and technical refinements显示文摘 | Amin AA Sakkary MA Khalil AA | 2011 | Head Neck Oncol2011，3，： | 1 |
| 9 | Discordance in fetal biometry and Doppler are independent predictors of the risk of perinatal loss in twin pregnancies显示文摘 | Khalil AA Khan N Bowe S | 2015 | Am J Obstet Gynecol2015，213，2： | 1 |
| 10 | Squamous cell carcino- ma of the cervix implanting in the episiotomy site 显示文摘 | Khalil AM Khatib RA Mufarrij AA | 1993 | Gynecol 0nco11993，51，： | 1 |
| 11 | A planning study of radiotherapy dose escalation of PET-active tumour volumes in non-small cell lung cancer patients 显示文摘 | M~ller DS Khalil AA Knap MM | 2011 | Acta Oncol2011，50，6： | 1 |
| 12 | Depressive symptoms and dietary nonadherence in patients with end -stage renal disease receiving hemodialysis: a review of quantitative evidence显示文摘 | Khalil AA Frazier SK | 2010 | Issues Ment Health Nurs2010，31，5： | 1 |
| 13 | Cisplatin and hyperthermia treatment of a C3H mammary carcinoma in vivo显示文摘 | Lindegaard J Radacic M Khalil AA | 1992 | Acta oncologica1992，31，： | 1 |
| 14 | Development of radiation pneumopathy and generalised radiological changes after radiotherapy are independent negative prognostic factors for survival in non-small cell lung cancer patients 显示文摘 | FarrKP Khalil AA Knap MM | 2013 | RadiotherOncol2013，107，3： | 1 |
| 15 | Hepatitis C in dialysis pa-tients in egypt:relationship to dialysis dura-tion,blood transfusion,and liver disease显示文摘 | Hassan AA Khalil R | 2000 | Saudi J Kidney Dis Transpl2000，11，： | 1 |
| 16 | Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum显示文摘 | Lukacova S Khalil AA Overgaard J | 2005 | Int J Radiat Biol2005，81，12： | 1 |
| 17 | What fac- tors detemine academic achievement in high achieving undergraduate medical students?A qualitative study 显示文摘 | Abdulghani HM AI-Drees AA Khalil MS el al | 2014 | Med Teach2014，36，1： | 1 |
| 18 | Renal stone disease and obesity:what is important for urologists and nephrologists?显示文摘 | Ahmed MH Ahmed HT Khalil AA | 2012 | Renal Failure2012，34，10： | 1 |
| 19 | Predictors of dietary and fluid non-adherence in Jordanian patients with end-stage renal disease receiving haemodialysis:A cross-sectional study显示文摘 | Khalil AA Darawad M AGamal E | | 0，，： | 1 |
| 20 | The influence of hypoxia and pH on bioluminescence imaging of luciferase-transfected tumor cells and xenografts显示文摘 | Khalil AA Jameson MJ Broaddus WC | 2013 | IntJ Mol Imaging2013，2013，28： | 1 |
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