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| 1 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，9： | 1 |
| 4 | Dynamic mechanical analysis of carbon/epoxy composites for structural pipeline repair 显示文摘 | Goertzen W K Kessler M R | 2007 | Composite B2007，38，1： | 1 |
| 5 | Creep behavior of carbon fi- ber/epoxy matrix composites显示文摘 | Goerzen W K Kessler M R | 2006 | Mater Sci Eng A2006，421，12： | 1 |
| 6 | Identification of potential cell-surfaceproteins in Candida albicans and investigation of the role of aputative cell-surface glycosidase in adhesion and virulence显示文摘 | Alberti-Segui C Morales A J Xing H Kessler M M Willins DA Weinstock K G | 2004 | Yeast2004，21，： | 1 |
| 7 | The Di- mensionality of Counterproductivity: Are All Counterproductive Behaviors Created Equal 显示文摘 | Spector P E Fox S Penney L M Bruursema K Goh A Kessler S | 2006 | Journal of Vocational Behavior2006，，03： | 1 |
| 8 | Effect of a zirconium tungstate filler on the cure behavior of a cyanate ester resin显示文摘 | Haman K Badrinarayanan P Kessler M R | 2009 | ACS Applied Materials & Interfaces2009，1，6： | 1 |
| 9 | Bone mineralization defects and vitamin D deficiency:histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients显示文摘 | Priemel M von Domarus C Klatte TO Kessler S Schlie J Meier S Proksch N Pastor F Netter C Streichert T Püschel K Amling M | | 0，，： | 1 |
| 10 | The Dimensionality of Counterproductively: Are all Counterproductive Behaviors Created Equal 显示文摘 | Spector P E Fox S Penney L M Bruursema K Goh A Kessler S | 2006 | Journal of Vocational Behavior2006，68，3： | 1 |
| 11 | The Dimensionality of Counter productiv- ity:Are All Counterproductive Behaviors Created Equal? 显示文摘 | Speetor P E Fox S Penney L M Bruursema K Goh A and Kessler S | 2006 | Journal of Vocational Behavior2006，68，3： | 1 |
| 12 | Review of human injuries,illness and economics losses caused by wildlife in the United States显示文摘 | Pitt W C Kessler K K | 1995 | Wildlife Society Bulletin1995，23，3： | 1 |
| 13 | Dynamic mechanical analysis of carbon/epoxy composites for structural pipeline repair 显示文摘 | Goertzen W K Kessler M R | 2007 | Composites Part B : Engineering2007，38，1： | 1 |
| 14 | Reproducibility and circadian rhythm of heart rate variability in healthy subjects显示文摘 | Kessler K M Terracall E | 1990 | Am J Cardiol1990，65，5： | 1 |
| 15 | Sudden cardiac death:epidemiology,transient risk,and intervention assessment显示文摘 | MYERBURG R J KESSLER K M CASTELLANOS A | 1993 | Ann Intern Med1993，119，12： | 1 |
| 16 | Thermal and mechanical evaluation of cyanate ester composites with lowtemperature proeessability显示文摘 | | 2007 | Composites Part A:Applied Science and Manufacturing2007，38，3： | 1 |
| 17 | Use of Veff and iso-NTCP in the implementation of dose escalation protocols 显示文摘 | Ten Haken R K Martel M K Kessler M L | 1993 | Int J Radiat Oncol Biol Phys1993，27，3： | 1 |
| 18 | The use of 3-D dose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，4： | 1 |
| 19 | Gprof: a call graph execution profiler显示文摘 | GRAHAM S L KESSLER P B MCKUSICK M K | 2004 | ACM SIGP- LAN Notices2004，39，4： | 1 |
| 20 | Gprof: A call graph execution profiler显示文摘 | Graham S L Kessler P B Mckusick M K | 1982 | ACM Sigplan Notices1982，17，6： | 1 |
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