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| 1 | Pathophysiology, epidemiology, classification and treatment options for polycystic liver diseases显示文摘Polycystic liver diseases(PLD)represent a group of genetic disorders in which cysts occur in the liver(autosomal dominant polycystic liver disease)or in combination with cysts in the kidneys(autosomal dominant polycystic kidney disease).Regardless of the genetic mutations,the natural history of these disorders is alike.The natural history of PLD is characterized by a continuous increase in the volume and the number of cysts.Both genders are affected;however,women have a higher prevalence.Most patients with PLD are asymptomatic and can be managed conservatively.Severe symptoms can affect 20%of patients who develop massive hepatomegaly with compression of the surrounding organs.Rrarely,patients with PLD suffer from acutecomplications caused by the torsion of hepatic cysts,intraluminal cystic hemorrhage and infections.The most common methods for the diagnosis of PLD are cross sectional imaging studies.Abdominal ultrasound and computerized tomography are the two most frequently used investigations.Magnetic resonance imaging is more sensitive and specific,and it is a valuable test for patients with intravenous contrast allergies or renal dysfunction.Different treatment modalities are available to physicians caring for these patients.Medical treatment has been ineffective.Percutaneous sclerotherapy,transarterial embolization,cyst fenestration,hepatic resection and liver transplantation are indicated to specific groups of patients and have to be tailored according to the extent of disease.This review outlines the current knowledge of the pathophysiology,clinical course,diagnosis and treatment strategies of PLD. | Bassam Abu-Wasel Caolan Walsh Valerie Keough Michele Molinari | 2013 | World Journal of Gastroenterology2013，19，35： | 10 |
| 2 | Immobilized lipasemediated acidolysis of butter oil with conjugated linoleic acid: batch reactor and packed bed reactorstudies显示文摘 | GARCIA H S ACROS J A KEOUGH K J | 2001 | Journal of Molecular Catalysis B: Enzymatic2001，11，46： | 1 |
| 3 | Effects of Selection Practiced on the Frequencies of K-casein and β-lactoglobulm Genotypes in Canadian Artificial Insemination Bulls显示文摘 | SABOUR M P LIN C Y KEOUGH A | 1993 | Journal Dairy Science1993，76，： | 1 |
| 4 | A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for poststroke recovery显示文摘 | MacLellan CL Keough MB Granter-Button S | | 0，，： | 1 |
| 5 | Regulation of a hair follicle keratin intermediate filament gene promoter显示文摘 | Dunn S M Keough R A Rogers G E | 1998 | Journal of Cell Science1998，111，： | 1 |
| 6 | Zinc-binding of endostatin is essential for its antiangiogenic activity显示文摘 | Boehm T O'Reilly MS Keough K | 1998 | Biochem Biophys Res Commun1998，252，1： | 1 |
| 7 | Ticagrelor as an alternative in clopidogrel-flssociated neutropenia显示文摘 | Shah R Keough LA Belalcazar-Portacio A | 2015 | Platelets2015，26，1： | 1 |
| 8 | Blunt chest trauma:review of selected pulmonary injuries focusing on pulmonary contusion显示文摘 | Keough V Pudelek B | 2001 | AACN Clin Issues2001，12，2： | 1 |
| 9 | An improved method for synthesis and purification of ^125I or ^131I labled carrier free 5-iodo-2'-deoxyuridine 显示文摘 | Keough WG Hofer KG | 1978 | J Labelled Comp Radiopharm1978，14，： | 1 |
| 10 | A method for high-sensitivity peptide sequencing using postsource decay matrix-assisted laser desorption ionization mass spectrometry显示文摘 | KEOUGH T YOUNGQUIST R S | 1999 | PNAS1999，13，： | 1 |
| 11 | A method for high-sensitivity peptide sequencing using postsource decay matrix-assisted laser desorption ionization mass spectrometry显示文摘 | KEOUGH T YOUNGQUIST R S LACET M P | 1999 | Proc Natl Acad Sci1999，96，13： | 1 |
| 12 | Blunt chest trauma: review of selected pulmonary injuries focusing on pulmonary eontusion显示文摘 | Keough V Pudelek B | 2001 | AACN Clin lnsues2001，12，2： | 1 |
| 13 | Water-based exercise in COPD with physical comorbidities:a randomised controlled trial显示文摘 | Mc Namara RJ Mc Keough ZJ Mc Kenzie DK | 2013 | Eur Respir J2013，41，6： | 1 |
| 14 | Derivatization procedures to facilitate de novo se-quencing of |ysine-terminated tryptic peptides u- sing postsource decay matrix-assisted laser de- sorption/ionization mass spectrometry显示文摘 | KEOUGH T LACEY M P YOUNGQUIST R S | 2000 | Rapid Commun Mass Spectrom2000，14，24： | 1 |
| 15 | A method for high-sensitivity peptide sequencing using postsource decay matrix-assisted laser desorption ionization mass spectrometry显示文摘 | Keough T Youngquist R S Lacey M P | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 16 | A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for poststroke recovery显示文摘 | MacLellan CL Keough MB Granter-Button S | 2011 | Neurorehabil Neural Repair2011，25，8： | 1 |
| 17 | Anxiety disorders and suicidality in the National Comorbidi- ty Survey-Replication 显示文摘 | Cougle JR Keough ME Riccardi C J | 2009 | J Psychiatr Res2009，43，： | 1 |
| 18 | A ten-unit all-ceramic anterior fixed partial denture using Y-TZP zircoaia显示文摘 | Keough BE Kay HB Sager RD | 2006 | Pract Proced Aesthet Dent2006，18，1： | 1 |
| 19 | Zinc-binding of endostatin is essential for its antiangiogenic activity显示文摘 | Boehm T O'reilly M S Keough K | 1998 | Biochem Biophys Res Commun1998，252，1： | 1 |
| 20 | A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for poststroke recovery显示文摘 | MacLellan C L Keough M B Granter-Button S | 2011 | Neurorehabil Neural Repair2011，25，8： | 1 |
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