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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Molecular targets in the treatment of anxiety显示文摘 | Kent J M Mathew S J Gorman J M | 2002 | Biol Psychiatry2002，52，10： | 2 |
| 4 | The state of the art of thezebrafish model for toxicology and toxicologic patholo- gy research-Advantages and current limitations 显示文摘 | Spitsbergen J M Kent M L | 2003 | Toxicology Pathology2003，，： | 1 |
| 5 | Mycobacteriosis in zebrafish ( Danio rerio ) research facilities 显示文摘 | Kent M L Whipps C M Matthews J L | 2004 | Comparative Biochemistry and Physiology Part C2004，138，： | 1 |
| 6 | Unilateral breast masses in men over 40 : a diagnostic dilemma显示文摘 | O' HANLON D M KENT P KERIN M J | 1995 | Am J Surg1995，170，： | 1 |
| 7 | Defining regionsof the Yechromosome responsible formale infertility and identification of a fourthAZFregion(AZFd) by Y chromo some micro deletion detection显示文摘 | Kent First M Muallem A Shuhz J | 1999 | MolReprod Dev1999，53，1： | 1 |
| 8 | Postmortem proteolysis is reduced in transgenic mice overexpressing calpastatin 显示文摘 | Kent M P Spencer M J Koohmaraie M | 2004 | Journal of Animal Science2004，82，3： | 1 |
| 9 | Defining regions of the Y chromosome responsible for male infertility and identification of afourth AZF region (AZFd) by Y chromosome microdeletion detection 显示文摘 | Kent - First M Muallem A Shultz J | 1999 | Mol Rep rod Dev1999，53，1： | 1 |
| 10 | Brain oedema in focal ischaemia:molecular pathophysiology and theoretical implications显示文摘 | Simard J M Kent T A Chen M | 2007 | Lancet Neurol2007，6，3： | 1 |
| 11 | Palaeohydrological records derived from testate amoebae analysis from peatlands in northern England: within-site variability, between-site comparability and palaeoclimatic implications 显示文摘 | Hendon D Charman D J Kent M | 2001 | Holocene2001，11，： | 1 |
| 12 | The midgut bacterial flora of wild Aedes triseriatus, Culex pipiens, and Psorophora columbiae mosquitoes显示文摘 | Demaio J Pumpuni CB Kent M | 1996 | American Journal of tropical Medicine and Hygiene1996，54，2： | 1 |
| 13 | Seed banks as a neglected area of biogeographic research: A review of literature and sampling techniques显示文摘 | Warr S J Thompson K Kent M | 1993 | Progess in Physical Geography1993，17，： | 1 |
| 14 | Tissue distribution and clearance of tritium-labeled dihydro microcystin-LR epimers administered to Atlantic salmon via intraperitoneal injention显示文摘 | Williams D E Kent M L Andersen R J | 1995 | Toxicon1995，33，： | 1 |
| 15 | Mississippi- an Barnett Shale, Fort Worth Basin, north central Texas: Gas-shale play with multi-trillion cubic foot potential显示文摘 | SCOTT L M DANIEL M J KENT A B | 2005 | AAPG Bulletin2005，89，2： | 1 |
| 16 | Global optimization of the generalized cross-validation criterion 显示文摘 | Kent J T Mohammadzadeh M | 2000 | Statistics and Computing2000，10，3： | 1 |
| 17 | Carbon clusters near the crossover to fullerene stability显示文摘 | Kent P R C Towler M D Needs R J | 2000 | Phys Rev B2000，62，15： | 1 |
| 18 | Brain oedema in focal ischaemia:molecular pathophysiology and theoretical implica- tions显示文摘 | Simard J M Kent T A Chen M | 2007 | Lancet Neurol2007，6，3： | 1 |
| 19 | The ac- curacy of wind observations from ships显示文摘 | TAYLOR P K KENT E C YELLAND M J | 1995 | Advances in the Applications of Marine Climatology1995，2，2： | 1 |
| 20 | The state of the art of the ze- brafish model for toxicology and toxicologic pathology research- advantages and current limitations 显示文摘 | SPITSBERGEN J M KENT M L | 2003 | Toxicologic Pathology2003，31，1： | 1 |
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