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| 1 | Non-alcoholic steatohepatitis and risk of hepatocellular carcinoma显示文摘The emergence of non-alcoholic fatty liver disease(NAFLD)as the leading chronic liver disease worldwide raises some concerns.In particular,NAFLD is closely tied to sedentary lifestyle habits and associated with other metabolic diseases,such as obesity and diabetes.At the end of the disease spectrum,non-alcoholic steatohepatitis(NASH)may progress to cirrhosis and hepatocellular carcinoma(HCC),representing a serious health problem to modern society.Recently,an increasing number of HCC cases originating from this progressive disease spectrum have been identified,with different levels of severity and complications.Updating the current guidelines by placing a bigger focus on this emerging cause and highlighting some of its unique features is necessary.Since,the drivers of the disease are complex and multifactorial,in order to improve future outcomes,having a better understanding of NASH progression into HCC may be helpful.The risks that can promote disease progression and currently available management strategies employed to monitor and treat NASH-related HCC make up the bulk of this review. | Rafael S.Rios Kenneth I.Zheng Ming-Hua Zheng | 2021 | Chinese Medical Journal2021，，24： | 3 |
| 2 | A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease:a derivation and independent validation study显示文摘Background:Currently,there are no effective methods for assessing hepatic inflammation without resorting to histological examination of liver tissue obtained by biopsy.T2-weighted images(T2WI)are routinely obtained from liver magnetic resonance imaging(MRI)scan sequences.We aimed to establish a radiomics signature based on T2WI(T2-RS)for assessment of hepatic inflammation in people with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 203 individuals with biopsy-confirmed NAFLD from two independent Chinese cohorts with liver MRI examination were enrolled in this study.The hepatic inflammatory activity score(IAS)was calculated by the unweighted sum of the histologic scores for lobular inflammation and ballooning.One thousand and thirty-two radiomics features were extracted from the localized region of interest(ROI)in the right liver lobe of T2WI and,subsequently,selected by minimum redundancy maximum relevance and least absolute shrinkage and selection operator(LASSO)methods.The T2-RS was calculated by adding the selected features weighted by their coefficients.Results:Eighteen radiomics features from Laplacian of Gaussian,wavelet,and original images were selected for establishing T2-RS.The T2-RS value differed significantly between groups with increasing grades of hepatic inflammation(P<0.01).The T2-RS yielded an area under the receiver operating characteristic(ROC)curve(AUROC)of 0.80[95%confidence interval(CI):0.71-0.89]for predicting hepatic inflammation in the training cohort with excellent calibration.The AUROCs of T2-RS in the internal cohort and external validation cohorts were 0.77(0.61-0.93)and 0.75(0.63-0.84),respectively.Conclusions:The T2-RS derived from radiomics analysis of T2WI shows promising utility for predicting hepatic inflammation in individuals with NAFLD. | Zhong-Wei Chen Huan-Ming Xiao Xinjian Ye Kun Liu Rafael S.Rios Kenneth I.Zheng Yi Jin Giovanni Targher Christopher D.Byrne Junping Shi Zhihan Yan Xiao-Ling Chi Ming-Hua Zheng | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 1 |
| 3 | The uprising of metabolic dysfunction-associated fatty liver disease(MAFLD)in acute-on-chronic liver failure(ACLF)显示文摘Metabolic dysfunction-associated fatty liver disease(MAFLD)(1)is currently the leading cause of chronic liver disease in the United States(US)and Europe,and the second leading cause for liver transplantation(2).Despite advancements in knowledge over the past decade,MAFLD-related cirrhosis is the most rapidly growing etiology for acute-on-chronic liver failure(ACLF)in the US(3-5).ACLF is a syndrome characterized by acute deterioration of cirrhosis and extrahepatic failure of 1 or more organs.ACLF represents a significant healthcare burden,and is associated with high short-term mortality.Recently,an epidemiology study showed a 3-fold increase in MAFLD-related ACLF waitlisted patients in the United Network for Organ Sharing(UNOS)database from 2005 to 2017(4),and a similar trend was observed in the European Liver Transplant Registry(ELTR)database(5).This is particularly concerning,as the quick rise in MAFLD-related ACLF has created a major gap between the number of patients requiring a liver transplant and the number of available liver donors. | Kenneth I.Zheng Ming-Hua Zheng | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 1 |
| 4 | Glycemic control predicts the risk of hepatic fibrosis in biopsy-proven NAFLD:a possible mediating role for leukemia inhibitory factor?显示文摘Background:Despite the clear link between nonalcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus,little is understood about how glycemic control impacts histological severity.We aimed to investigate the deeper association between hemoglobin A1c(HbA1c)and the histologic severity of liver fibrosis.Methods:A total of 568 adults with biopsy-proven NAFLD from the PERSONS cohort in Wenzhou were enrolled.The association between mean HbA1c and hepatic histological features was investigated with ordinal logistic regression.Generalized additive models were used to identify the non-linear relationship between HbA1c and increased fibrosis stage(stage F3).Causal mediation analysis was performed to calculate the indirect effect of the relationship between HbA1c and hepatic fibrosis mediated by cytokines.Results:Every 1%increase in mean HbA1c was associated with 16%higher odds of increased fibrosis stage(odds ratio 1.16,95%CI 1.04–1.30),even after adjustment for confounding factors.There was a non-linear association between HbA1c and increased fibrosis stage(stage F3),and the HbA1c inflection point was 9.2%.In particular,the ORs on the left and right sides of this inflection point were 2.1(95%CI 1.4–3.3)and 0.1(95%CI 0–4.8),respectively.7%of the association(OR 1.07,95%CI 1.01–1.12)between HbA1c and liver fibrosis was mediated by leukemia inhibitory factor.Conclusions:Glycemic control predicts severity of hepatic fibrosis and leukemia inhibitory factor plays an intermediary role between them,and thus optimizing glycemic control may be a means of modifying the risk of fibrosis progression in NAFLD. | Feng Gong Kenneth I.Zheng Liang-Jie Tang Gang Li Rafael S.Rios Ou-Yang Huang Yang-Yang Li Christopher D.Byrne Giovanni Targher Man Mi Na He Hong-Lei Ma Ming-Hua Zheng | 2022 | iLIVER2022，1，1： | 1 |
| 5 | Hemophagocytosis in a Severe COVID-19 Patient显示文摘The novel coronavirus(SARS-CoV-2)infection has become a heavy burden on global health.Although the coronavirus disease 2019(COVID-19)may adversely affect multiple organs and systems of infected patients,to the best of our knowledge,there is little investigation of the SARS-CoV-2’s impact on bone marrow.Our clinical and cytological findings in this case of severe COVID-19 infection provide novel insights into the pathogenesis of SARS-CoV-2 infection in the hematopoietic system.We recommend that physicians consider SARS-CoV-2 infection’s effect on bone marrow in patients who are slow to recover and suggest that a better understanding of the bone marrow morphology in COVID-19-infected patients is needed. | Kenneth I.Zheng Xianghong Jin Xuanru Lin Hong Lu Wenyue Liu Minghua Zheng | 2022 | Infectious Diseases & Immunity2022，2，1： | 0 |
| 6 | Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolicassociated Fatty Liver Disease显示文摘Background and Aims:In Europeans,variants in the hydroxysteroid 17-beta dehydrogenase 13(HSD17B13)gene impact liver histology in metabolic-associated fatty liver disease(MAFLD).The impact of these variants in ethnic Chinese is unknown.The aim of this study was to investigate the potential associations in Chinese patients.Methods:In total,427 Han Chinese with biopsy-confirmed MAFLD were enrolled.Two single nucleotide polymorphisms in HSD17B13 were genotyped:rs72613567 and rs6531975.Logistic regression was used to test the association between the single nucleotide polymorphisms and liver histology.Results:In our cohort,the minor allele TA of the rs72613567 variant was related to an increased risk of fibrosis[odds ratio(OR):2.93(1.20–7.17),p=0.019 for the additive model;OR:3.32(1.39–7.91),p=0.007 for the recessive model],representing an inverse association as compared to the results from European cohorts.In contrast,we observed a protective effect on fibrosis for the minor A allele carriers of the HSD17B13 rs6531975 variant[OR:0.48(0.24–0.98),p=0.043 for the additive model;OR:0.62(0.40–0.94),p=0.025 for the dominant model].HSD17B13 variants were only associated with fibrosis but no other histological features.Furthermore,HSD17B13 rs6531975 modulated the effect of PNPLA3 rs738409 on hepatic steatosis.Conclusions:HSD17B13 rs72613567 is a risk variant for fibrosis in a Han Chinese MAFLD population but with a different direction for allelic association to that seen in Europeans.These data exemplify the need for studying diverse populations in genetic studies in order to fine map genome-wide association studies signals. | Wen-Yue Liu Mohammed Eslam Kenneth I.Zheng Hong-Lei Ma Rafael S.Rios Min-Zhi Lv Gang Li Liang-Jie Tang Pei-Wu Zhu Xiao-Dong Wang Christopher D.Byrne Giovanni Targher Jacob George Ming-Hua Zheng | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 0 |
| 7 | When a new definition overhauls perceptions of MAFLD related cirrhosis care显示文摘Metabolic-associated fatty liver disease(MAFLD)(1),formerly known as non-alcoholic fatty liver disease,is a major causes of liver cirrhosis(2).MAFLD represents a growing global health and economic burden since approximately one in four people have the disease(3).As a consequence,MAFLD-related cirrhosis is expected to become the leading cause for liver failure and liver cancer,and the major indication for liver transplantation this century(3). | Kenneth I.Zheng Mohammed Eslam Jacob George Ming-Hua Zheng | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 0 |
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