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	题名	作者	年代	出处	被引量
1	Assessment of KL-6 as a tumor marker in patients with hepatocellular carcinoma显示文摘AIM: To investigate the clinical significance of KL-6 as a tumor marker of HCC in two different ethnic groups with chronic liver disease consecutively encountered at outpatient clinics.METHODS: Serum KL-6 was measured by the sandwich enzyme immunoassay method using the KL-6 antibody (Ab) as both the capture and tracerAb according to the manufacturer's instructions (Eisai, Tokyo, Japan).Assessment of alpha fetoprotein (AFP) and protein induced vitamin K deficiency or absence (PIVKA-Ⅱ) was performed in both groups using commercially available kits.RESULTS: A significantly higher mean serum KL-6(556±467 U/L) was found in HCC in comparison with non-HCC groups either with (391±176 U/L; P<0.001)or without (361±161 U/L; P<0.001) liver cirrhosis (LC).Serum KL-6 level did not correlate with either AFP or PIVKA-Ⅱ serU/Levels. Using receiver operating curve analysis for KL-6 as a predictor for HCC showed that the area under the curve was 0.574 (95%CI = 0.50-0.64)and the KL-6 level that gave the best sensitivity (61%) was found to be 334 U/L but according to the manufacturer's instructions; a cut-off point of 500 U/Lwas used that showed the highest specificity (80%)in comparison with AFP and PIVKA-Ⅱ (78% vs 72%respectively). Combining the values of the three markers improved specificity of AFP for HCC diagnosis from 78%for AFP alone; 93% for AFP plus PIVKA-Ⅱ to 99% for both plus KL-6 value (P<0.001). Mean serum alkaline phosphatase level was significantly higher in KL-6positive (564±475) in comparison with KL-6 negative (505±469) HCC patients (P = 0.021), but such a difference was not found among non-HCC corresponding groups.CONCLUSION: KL-6 is suggested as a tumor for HCC.Its positivity may reflect HCC-associated cholestasis and/or local tumor invasion.	Amal Gad Eiji Tanaka Akihiro Matsumoto Moushira Abd-el Wahab Abd el-Hamid Serwah Fawzy Attia Khalil Ali Howayda Hassouba Abd el-Raoof el-Deeb Tetsuya Ichijyo Takeji Umemura Hidetomo Muto Kaname Yoshizawa Kendo Kiyosawa	2005	World Journal of Gastroenterology2005，11，42：	8
2	PPAR[alpha] activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice显示文摘	Tanaka Naoki Moriya Kyoji Kiyosawa Kendo Koike Kazuhiko Gonzalez Frank J Aoyama Toshifumi	2008	Journal of Clinical Investigation2008，，2：	2
3	Long‐term outcome of Japanese patients with type 1 autoimmune hepatitis显示文摘	Kaname Yoshizawa Akihiro Matsumoto Tetsuya Ichijo Takeji Umemura Satoru Joshita Michiharu Komatsu Naoki Tanaka Eiji Tanaka Masao Ota Yoshihiko Katsuyama Kendo Kiyosawa Masanori Abe Morikazu Onji	2012	Hepatology2012，，：	2
4	Long-term use of entecavir in nucleoside-na?ve Japanese patients with chronic hepatitis B infection显示文摘	Osamu Yokosuka Koichi Takaguchi Shinichi Fujioka Michiko Shindo Kazuaki Chayama Haruhiko Kobashi Norio Hayashi Chifumi Sato Kendo Kiyosawa Kyuichi Tanikawa Hiroki Ishikawa Nobuyuki Masaki Taku Seriu Masao Omata	2010	Journal of Hepatology2010，，6：	2
5	Extracorporeal shock wave lithotripsy of pancreatic duct stones and patient factors related to stone disintegration显示文摘	Yasuyuki Karasawa Shigeyuki Kawa Yuji Aoki Yasuhide Ochi Hiroshi Unno Kendo Kiyosawa Tomofumi Watanabe	2002	Journal of Gastroenterology2002，，5：	2
6	production of tetrodotoxin in puffer fish embryo 显示文摘	Kendo M	1998	Enviromen Toxicol Pharmacol1998，6，：	1
7	Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis显示文摘	Hideaki Hamanou Shigeyuki Kawa Yasuhide Ochi Hiroshi Unno Nobuhiko Shiba Masahisa Wajiki Koh Nakazawa Hisashi Shimojo Kendo Kiyosawa	2002	The Lancet2002，，9315：	1
8	Highly Purified Eicosapentaenoic Acid Treatment Improves Nonalcoholic Steatohepatitis显示文摘	Naoki Tanaka Kenji Sano Akira Horiuchi Eiji Tanaka Kendo Kiyosawa Toshifumi Aoyama	2008	Journal of Clinical Gastroenterology2008，，4：	1
9	Uhrastructural difference between the propagative and dispersal forms in pine wood nematode, Bursaphelenchus lignicolus, with reference to the survival 显示文摘	Kendo E Ishibashi N	1978	Appl Entoml Zool1978，13，：	1
10	HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the japanese population显示文摘	Shigeyuki Kawa Masao Ota Kaname Yoshizawa Akira Horiuchi Hideaki Hamano Yasuhide Ochi Kohzo Nakayama Yuriko Tokutake Yoshihiko Katsuyama Satoshi Saito Osamu Hasebe Kendo Kiyosawa	2002	Gastroenterology2002，，5：	1
11	Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients显示文摘	Akihiro Matsumoto Eiji Tanaka Akinori Rokuhara Kendo Kiyosawa Hiromitsu Kumada Masao Omata Kiwamu Okita Norio Hayashi Takeshi Okanoue Shiro Iino Kyuichi Tanikawa	2005	Hepatology Research2005，，3：	1
12	Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis显示文摘	Hideaki Hamano Norikazu Arakura Takashi Muraki Yayoi Ozaki Kendo Kiyosawa Shigeyuki Kawa	2006	Journal of Gastroenterology2006，，12：	1
13	Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients显示文摘	Akihiro Matsumoto Eiji Tanaka Akinori Rokuhara Kendo Kiyosawa Hiromitsu Kumada Masao Omata Kiwamu Okita Norio Hayashi Takeshi Okanoue Shiro Iino Kyuichi Tanikawa	2005	Hepatology Research2005，，3：	1
14	ERCP features in 27 patients with autoimmune pancreatitis显示文摘	Akira Horiuchi Shigeyuki Kawa Hideaki Hamano Masayoshi Hayama Hiroyoshi Ota Kendo Kiyosawa	2002	Gastrointestinal Endoscopy2002，，4：	1
15	Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients显示文摘	Akihiro Matsumoto Eiji Tanaka Akinori Rokuhara Kendo Kiyosawa Hiromitsu Kumada Masao Omata Kiwamu Okita Norio Hayashi Takeshi Okanoue Shiro Iino Kyuichi Tanikawa	2005	Hepatology Research2005，，3：	1
16	Indirect competitive enzyme immunoassay for tetrodotoxin using a biotin - avidin system显示文摘	Sadako Fukiya	1992	Seafood toxins1992，75，5：	1
17	A monoclonal antibody against tetrodotoxin that reacts to the activegroup for the toxicity显示文摘		1995	Environmental toxicology1995，293，：	1
18	Epidemiology of hepatocellular carcinoma in Japan显示文摘	Takeji Umemura Tetsuya Ichijo Kaname Yoshizawa Eiji Tanaka Kendo Kiyosawa	2009	Journal of Gastroenterology2009，，19：	1
19	Hepatocellular carcinoma: Recent trends in Japan显示文摘	Kendo Kiyosawa Takeji Umemura Tetsuya Ichijo Akihiro Matsumoto Kaname Yoshizawa Amal Gad Eiji Tanaka	2004	Gastroenterology2004，，5：	1
20	Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis显示文摘	Masao Ota Yoshihiko Katsuyama Hideaki Hamano Takeji Umemura Akinori Kimura Kaname Yoshizawa Kendo Kiyosawa Hirofumi Fukushima Seiamak Bahram Hidetoshi Inoko Shigeyuki Kawa	2007	Immunogenetics2007，，1：	1

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