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| 1 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 2 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 5 | Medications as a Potential Source of Exposure to Phthalates in the U.S. Population显示文摘 | Hernández-Díaz Sonia Mitchell Allen A Kelley Katherine E Calafat Antonia M Hauser Russ | 2009 | Environmental Health Perspectives2009，，2： | 2 |
| 6 | Factors in tonsillectomy mortalily显示文摘 | Alexander D W Graff T D Kelley E | 1965 | Arch Otolaryngol1965，82，4： | 1 |
| 7 | Direct,facile synthesis of acyo azides and nitriles from carboxylic acids using bis(2-methoxyethyl)aminosulfur trifluoride显示文摘 | Kangani CO Day B W Kelley D E | 2007 | Tetrahedron Lett2007，48，： | 1 |
| 8 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 9 | Endogenous production and exogenous exposure to nitric oxide augment doxorubicin cytotoxicity for breast cancer cells but not cardiac myoblasts显示文摘 | Evig C B Kelley E E Weydert C J | 2004 | Nitric Oxide2004，10，3： | 1 |
| 10 | Exploring for deeply-covered mineral deposits : Formation of geochemical anomalies in Northern Chile by earthquake- induced surface flooding of mineralized groundwaters 显示文摘 | Cameron E M Leybourne M I Kelley D L | 2002 | Geology2002，30，11： | 1 |
| 11 | Knowledge and perceptions of couples' voluntary counseling and testing in urban Rwanda and Zambia: a cross - sectional household survey 显示文摘 | Kelley AL WKarita E Sullivan PS | 2011 | PIoS One2011，6，19： | 1 |
| 12 | A branch-current-based state estimation method for distribution systems显示文摘 | BARAN M E KELLEY A W | 1995 | IEEE Trans on Power Systems1995，10，1： | 1 |
| 13 | The use of partial extraction geochemistry for copper esploration in northern Chile显示文摘 | Kelley D L Hall G E M Graham Closs L | 2003 | Geochemistry: Exploration Environment Analysis2003，3，1： | 1 |
| 14 | A prospective assess- ment of mortality in chronic spinal cord injury 显示文摘 | Garshick E Kelley A Cohen SA | 2005 | Spinal Cord2005，43，7： | 1 |
| 15 | Dysfunction in mitochondria in human skeletal muscle in type 2 diabetes显示文摘 | KELLEY D E HE J MENSHIKOVA E V | 2002 | Diabetes2002，51，： | 1 |
| 16 | 查看详情显示文摘 | Aurbach D Pollak E Elazari R Salitra G Kelley C.S Affinito J | | 0，，： | 1 |
| 17 | A branch-current-based state estimation method for distribution system显示文摘 | BARAN M E KELLEY A W | | 0，，1： | 1 |
| 18 | Knowledge and perceptions of couples' voluntary counseling and testing in urban Rwanda and Zambia:a cross-sectional household survey显示文摘 | Kelley AL Karita E Sullivan PS | | 0，，05： | 1 |
| 19 | The adult neck mass显示文摘 | Schwetschenau E Kelley DJ | 2002 | Am Fam Physician2002，66，： | 1 |
| 20 | Changes in gene expression by trabecular meshwork cells in response to mechanical stretching显示文摘 | Vittal V Rose A Gregory K E Kelley M J Acott T S | 2005 | Invest Ophthalmol Vis Sci2005，46，： | 1 |
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