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| 1 | Cancer risk in primary sclerosing cholangitis: Epidemiology,prevention, and surveillance strategies显示文摘Primary sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly,PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma,hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty remains regarding how to best do so. In this review, we discuss the epidemiology, prevention, and surveillance of cancers in patients with PSC. Where evidence is limited, we present pragmatic approaches based on currently available data and expert opinion. | Brian M Fung Keith D Lindor James H Tabibian | 2019 | World Journal of Gastroenterology2019，25，6： | 15 |
| 2 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 3 | Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats 显示文摘 | Keith I M Tjen-A-Looi S Kraiczi H | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 2 |
| 4 | Esophageal lichen planus:A case report and review of the literature显示文摘Esophageal involvement by lichen planus(ELP),previously thought to be quite rare,is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus(LP).Considering that the symptoms of ELP do not present in a predictable manner,ELP is perhaps more under-recognized than rare.To date,four cases of squamous cell carcinoma in association with ELP have been reported,suggesting that timely and accurate diagnosis of ELP is of importance for appropriate follow-up.In this case report,a 69-year-old female presented with dysphagia and odynophagia.She reported a history of oral LP but had no active oral or skin lesions.Endoscopic examination revealed severe strictures and web-like areas in the esophagus.Histologic examination demonstratedextensive denudation of the squamous epithelium,scattered intraepithelial lymphocytes,rare eosinophils and dyskeratotic cells.Direct immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous disorders.By using clinical,endoscopic,and histologic data,a broad list of differential diagnoses can be narrowed,and the accurate diagnosis of ELP can be made,which is essential for proper treatment and subsequent follow-up. | Jennifer A Nielsen Robert M Law Keith H Fiman Cory A Roberts | 2013 | World Journal of Gastroenterology2013，19，14： | 1 |
| 5 | Isotopic composition and environment classification of selected limestone and fossils显示文摘 | Keith M H Weber J H | 1964 | Geochemical Cosmochimica Acta1964，28，： | 1 |
| 6 | A randomized, pharmacokinetic and pharmacodynamic, cross-over study of duodenal or jejunal administration compared to nasogastric administration of omeprazole suspension in patients at risk for stress ulcers显示文摘 | Jeffrey O Phillips Keith M Olsen Jill A Rebuck Nick J Rangnekar Brent W Miedema Michael H Metzler | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 7 | Biosensor technology: technology push versus market pull显示文摘 | JOHN H T L KEITH B M JEREMY D G | 2008 | Biotechn Adv2008，26，5： | 1 |
| 8 | Climate strategy with CO2 capture from the air显示文摘 | Keith D W Duong M H Stolaroff J K | 2006 | Climatic Change2006，74，： | 1 |
| 9 | The effect of lignin-related compounds on the growth and production of laccases by the ascomycete,Botryosphaeria sp显示文摘 | Dekker Robert F H Barbosa Aneli M Sargent Keith | 2002 | Enzyme and Microbial Technology2002，30，3： | 1 |
| 10 | Evidence for a Second Crystal Form of Polypropylene显示文摘 | Keith H D Padden F J Walter N M | 1959 | J Appl Phys1959，30，10： | 1 |
| 11 | Blood flow direction in the lumhar nerve root显示文摘 | Natio M Jeffrey H Keith H | 1990 | Spine1990，15，96： | 1 |
| 12 | Evidence for a second crystal form of polypropylene显示文摘 | Keith H D Padden F J Jr Walter N M | 1959 | Appl Phys1959，30，： | 1 |
| 13 | Kimura?s Disease: Case Report and Review of the Literature显示文摘 | Carla M Hobeika Tan-Lucien H Mohammed Gregory L Johnson Keith Hansen | 2005 | Journal of Thoracic Imaging2005，，4： | 1 |
| 14 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 15 | Input of carbon to soil from wheat plants显示文摘 | Keith H Oades J M Martin J K | 1986 | Soil Biol Bioehem1986，18，： | 1 |
| 16 | Soft tissue and intra-articular injection bubivacaine,epinephrine,and morphine has a beneficial effect after total knee arthroplasty显示文摘 | Adolph V L Keith R B Tomas H M | 2004 | Clin Orthop Relat Res2004，，428： | 1 |
| 17 | Assessing genetic stability of a range of terrestrial microalgae after cryopreservation using ampli- fied fragment length polymorphism显示文摘 | Julia M John G Keith H | 2007 | American Journal of Bota- ny2007，94，5： | 1 |
| 18 | Evi- dence for a second crystal form of polypropylene 显示文摘 | Keith H D Padden F J Jr Walter N M | 1959 | Applied Physics1959，30，12： | 1 |
| 19 | The ner Gene of Photorhabdus: effects on Primary-Form-Specific Phenotypes and Outer Membrane Protein Composition显示文摘 | O'NEILL DECLAN M | 2002 | J Bacteriol2002，184，： | 1 |
| 20 | Noninvasive soil water content measurement using electromagnetic induction显示文摘 | Hendrickx Jan M H | 1995 | Water Resources Research1995，31，10： | 1 |
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