|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lessons learned from an audit of 1250 anal fistula patients operated at a single center:A retrospective review显示文摘BACKGROUND A complex anal fistula is a challenging disease to manage.AIM To review the experience and insights gained in treating a large cohort of patients at an exclusive fistula center.METHODS Anal fistulas operated on by a single surgeon over 14 years were analyzed.Preoperative magnetic resonance imaging was done in all patients.Four procedures were performed:fistulotomy;two novel sphincter-saving procedures,proximal superficial cauterization of the internal opening and regular emptying and curettage of fistula tracts(PERFACT)and transanal opening of intersphincteric space(TROPIS),and anal fistula plug.PERFACT was initiated before TROPIS.As per the institutional GFRI algorithm,fistulotomy was done in simple fistulas,and TROPIS was done in complex fistulas.Fistulas with associated abscesses were treated by definitive surgery.Incontinence was evaluated objectively by Vaizey incontinence scores.RESULTS A total of 1351 anal fistula operations were performed in 1250 patients.The overall fistula healing rate was 19.4%in anal fistula plug(n=56),50.3%in PERFACT(n=175),86%in TROPIS(n=408),and 98.6%in fistulotomy(n=611)patients.Continence did not change significantly after surgery in any group.As per the new algorithm,1019 patients were operated with either the fistulotomy or TROPIS procedure.The overall success rate was 93.5%in those patients.In a subgroup analysis,the overall healing rate in supralevator,horseshoe,and fistulas with an associated abscess was 82%,85.8%,and 90.6%,respectively.The 90.6%healing rate in fistulas with an associated abscess was comparable to that of fistulas with no abscess(94.5%,P=0.057,not significant).CONCLUSION Fistulotomy had a high 98.6%healing rate in simple fistulas without deterioration of continence if the patient selection was done judiciously.The sphincter-sparing procedure,TROPIS,was safe,with a satisfactory 86%healing rate for complex fistulas.This is the largest anal fistula series to date. | Pankaj Garg Baljit Kaur Ankita Goyal Vipul D Yagnik Sushil Dawka Geetha R Menon | 2021 | World Journal of Gastrointestinal Surgery2021，13，4： | 8 |
| 2 | Ribosome Inactivating Proteins from Plants Inhibiting Viruses显示文摘Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and herpes simplex virus (HSV). Most of the research work related to RIPs has been focused on antiviral activity against HIV; however, the exact mechanism of antiviral activity is still not clear. The mechanism of antiviral activity was thought to follow inactivation of the host cell ribosome, leading to inhibition of viral protein translation and host cell death. Enzymatic activity of RIPs is not limited to depurination of the large rRNA, in addition they can depurinate viral DNA as well as RNA. Recently, Phase I/II clinical trials have demonstrated the potential use of RIPs for treating patients with HIV disease. The aim of this review is to focus on various RIPs from plants associated with anti-HIV activity. | Inderdeep Kaur R C Gupta Munish Puri | 2011 | Virologica Sinica2011，26，6： | 7 |
| 3 | Guidelines on postoperative magnetic resonance imaging in patients operated for cryptoglandular anal fistula:Experience from 2404 scans显示文摘Magnetic resonance imaging(MRI)is considered the gold standard for the evaluation of anal fistulas.There is sufficient literature available outlining the interpretation of fistula MRI before performing surgery.However,the interpretation of MRI becomes quite challenging in the postoperative period after the surgery of fistula has been undertaken.Incidentally,there are scarce data and no set guidelines regarding analysis of fistula MRI in the postoperative period.In this article,we discuss the challenges faced while interpreting the postoperative MRI,the timing of the postoperative MRI,the utility of MRI in the postoperative period for the management of anal fistulas,the importance of the active involvement and experience of the treating clinician in interpreting MRI scans,and the latest advancements in the field. | Pankaj Garg Baljit Kaur Vipul D Yagnik Sushil Dawka Geetha R Menon | 2021 | World Journal of Gastroenterology2021，27，33： | 6 |
| 4 | Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients显示文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes. | Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh Venkatesh R Naik | 2012 | World Journal of Gastroenterology2012，18，8： | 3 |
| 5 | Enrichment for murine keratinocyte stem cells based on cell surface phenotype显示文摘 | Tani H Morris R J Kaur P | 2000 | Proc Natl Acad Sci U S A2000，97，10： | 2 |
| 6 | Guidelines to diagnose and treat peri-levator high-5 anal fistulas: Supralevator, suprasphincteric, extrasphincteric, high outersphincteric, and high intrarectal fistulas显示文摘Supralevator,suprasphincteric,extrasphincteric,and high intrarectal fistulas(high fistulas in muscle layers of the rectal wall)are well-known high anal fistulas which are considered the most complex and extremely challenging fistulas to manage.Magnetic resonance imaging has brought more clarity to the pathophysiology of these fistulas.Along with these fistulas,a new type of complex fistula in high outersphincteric space,a fistula at the roof of ischiorectal fossa inside the levator ani muscle(RIFIL),has been described.The diagnosis,management,and prognosis of RIFIL fistulas is reported to be even worse than supralevator and suprasphincteric fistulas.There is a lot of confusion regarding the anatomy,diagnosis,and management of these five types of fistulas.The main reason for this is the paucity of literature about these fistulas.The common feature of all these fistulas is their complete involvement of the external anal sphincter.Therefore,fistulotomy,the simplest and most commonly performed procedure,is practically ruled out in these fistulas and a sphincter-saving procedure needs to be performed.Recent advances have provided new insights into the anatomy,radiological modalities,diagnosis,and management of these five types of high fistulas.These have been discussed and guidelines formulated for the diagnosis and treatment of these fistulas for the first time in this paper. | Pankaj Garg Vipul D Yagnik Sushil Dawka Baljit Kaur Geetha R Menon | 2022 | World Journal of Gastroenterology2022，28，16： | 2 |
| 7 | 显示文摘 | Singh R Kumar J Kaur A | 2006 | Polymer2006，47，： | 1 |
| 8 | Curcumin supplementation improves mitoehondrial and behavioral deficits in experimental model of chronic epilepsy 显示文摘 | Kaur H Bal A Sandhir R | 2014 | Pharmacol Biochem Behav2014，125，： | 1 |
| 9 | Inhibition of platelet-de- rived growth factorab signaling prevents electromechanieal remod- eling ofadult atrial myocytes that contact myofibroblasts 显示文摘 | Musa H Kaur K O'Connell R | 2013 | Heart Rhythm2013，10，7： | 1 |
| 10 | Soil carbon, microbial activity and nitrogen availability in agroforestry system on moderately alka- line soils in northern India 显示文摘 | KAUR B GUPTA S R SINGH G | 2000 | Applied Soil Ecology2000，15，3： | 1 |
| 11 | Diagnosis, staging, and surveillance of cervical carcinoma显示文摘 | Kaur H Silverman P M Iyer R B | 2003 | AJR2003，180，6： | 1 |
| 12 | Effects of the Mi 1, N and tabasco genes on infection and reproduction of Meloidogyne mayaguensis on tomato and pepper genotypes 显示文摘 | Brito J A Stanley J D Kaur R | 2007 | Journal of Nematology2007，39，4： | 1 |
| 13 | Identification of chemerin receptor (ChemR23) in human endothelial cells: Chemerin- induced endothelial angiogenesis显示文摘 | Kaur J Adya R Tan BK | 2010 | Biochem Biophys Res Commun2010，391，4： | 1 |
| 14 | Serodiagnosis of extra pulmonary tuberculosis using A-60 antigen 显示文摘 | Anuradha S Kaur R Singh NP | 2001 | J Commun Dis2001，33，1： | 1 |
| 15 | High-resolution CT in renal transplant patients with suspected pulmonary infections 显示文摘 | Gulati M Kaur R Jha V | 2000 | Acta Radiol2000，41，： | 1 |
| 16 | Comparative evaluation of different doses of propofol preceded by fentanyl on intubating conditions and pressor response during tracheal intubation without muscle relaxants显示文摘 | Gupta A Kaur R Malhotra R | 2006 | Pediatr Anesth2006，16，： | 1 |
| 17 | Fine particulate matter and carbon monoxide exposure concentrations in urban street transport microenvironment显示文摘 | KAUR S NIEUWENHUIJSENB M J COLVILE R N | | 0，，23： | 1 |
| 18 | A Holy Grail of asthma management:toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids显示文摘 | Giembycz MA Kaur M Leigh R | | 0，，： | 1 |
| 19 | Targeted Resequencing Reveals ALK Fusions in Non-Small Cell Lung Carcinomas Detected by FISH, Immunohistochemistry, and Real-Time RT-PCR: A Comparison of Four Methods显示文摘 | Katja Tuononen Virinder Kaur Sarhadi Aino Wirtanen Mikko R?nty Kaisa Salmenkivi Aija Knuuttila Satu Remes Aino I. Telaranta-Keerie Stuart Bloor Pekka Ellonen Sakari Knuutila Akanchha Kesari | 2013 | BioMed Research International2013，，： | 1 |
| 20 | Vendor Selection Problem (VSP) Using Fuzzy Analytical Hierarchy Process(FAHP)显示文摘 | Kaur P Verma R Mahanti N C | 2008 | International Journal of Soft Computing2008，3，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员