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| 1 | Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002. | Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser | 2009 | World Journal of Gastroenterology2009，15，35： | 7 |
| 2 | Robotic total meso-rectal excision for rectal cancer: A systematic review following the publication of the ROLARR trial显示文摘AIM To compare outcomes in patients undergoing rectal resection by robotic total meso-rectal excision(RTME) vs laparoscopic total meso-rectal excision(LTME).METHODS Standard medical electronic databases such as Pub-Med, MEDLINE, EMBASE and Scopus were searched to find relevant articles. The data retrieved from all types of included published comparative trials in pati-ents undergoing RTME vs LTME was analysed using the principles of meta-analysis. The operative, post-operative and oncological outcomes were evaluated to assess the effectiveness of both techniques of TME. The summated outcome of continuous variables was expressed as standardized mean difference(SMD) and dichotomous data was presented in odds ratio(OR).RESULTS One RCT(ROLARR trial) and 27 other comparative studies reporting the non-oncological and oncological outcomes following RTME vs LTME were included in this review. In the random effects model analysis using the statistical software Review Manager 5.3, the RTME was associated with longer operation time(SMD, 0.46; 95%CI: 0.25, 0.67; z = 4.33; P = 0.0001), early passage of first flatus(P = 0.002), lower risk of conversion(P = 0.00001) and shorter hospitalization(P = 0.01). The statistical equivalence was seen between RTME and LTME for non-oncological variables like blo-od loss, morbidity, mortality and re-operation risk. The oncological variables such as recurrence(P = 0.96), number of harvested nodes(P = 0.49) and positive circumferential resection margin risk(P = 0.53) were also comparable in both groups. The length of distal resection margins was similar in both groups. CONCLUSION RTME is feasible and oncologically safe but failed to demonstrate any superiority over LTME for many sur-gical outcomes except early passage of flatus, lower risk of conversion and shorter hospitalization. | Katie Jones Mohamed G Qassem Parv Sains Mirza K Baig Muhammad S Sajid | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 4 |
| 3 | Addressing concerns about cisplatin application during pregnancy显示文摘 | Malgorzata Lanowska Christhardt K?hler Peter Oppelt Alexander Schmittel Elisabeth Gottschalk Kati Hasenbein Achim Schneider Simone Marnitz | 2011 | Journal of Perinatal Medicine2011，，3： | 2 |
| 4 | The effect of intravenous ketoprofen on postoperative epidnral snfentanil analgesia in children 显示文摘 | Hannu K Kati T Heikki H | 2000 | Anesth Analg2000，88，5： | 1 |
| 5 | A closterovirus (family: Closteroviridae) isolated from tobacco crops in Northern Greece (Macedonia)显示文摘 | Chatzivassiliou E K Katis N I Tchomguia M | 1999 | Plant Disease1999，83，： | 1 |
| 6 | Integration of Remote Sensing and GIS with Flood Simulation Model for Flood Hazard Mapping in the Bafmati River, NEPAL 显示文摘 | Katie T P Hazarika M K Shrestha K G | 2006 | New Technologies for Urban Safety of Mega cities in Asia2006，，： | 1 |
| 7 | Non-targeted analysis of spatial metabolite composition in strawberry (Fragaria ananassa) flowers显示文摘 | Kati H Ilana R Harri K | 2008 | Phytochemistry2008，69，13： | 1 |
| 8 | Doula Care, Birth Outcomes and Costs Among Medicaid Benefi- ciarles显示文摘 | Katy B K | 2013 | American Journal of Public Health2013，103，4： | 1 |
| 9 | Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overprodu-cing the MexCD-OprJ Efflux Pump显示文摘 | Katy J Sylvie E Thilo K | 2008 | Antimicrob Agents2008，52，7： | 1 |
| 10 | Characterization of crystalline cellulose in biomass: basic principles, applications, and limitations of XRD, NMR, IR, Raman, and SFG显示文摘 | Kim S H Lee C M Katie K | 2013 | Korean Journal Chemistry Engineering2013，30，12： | 1 |
| 11 | Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overproducing the MexCD-OprJ El'flux Pump 显示文摘 | Katy J Sylvie E Thilo K | 2008 | Antimicrob Agents2008，52，7： | 1 |
| 12 | Production of transgenic strawberries by temporary immersion bioreactor system and verification by TAIL-PCR 显示文摘 | Kati J H Sirpa O K | 2007 | B M C Biotechnol2007，19，： | 1 |
| 13 | Angiotensin | con- verting enzyme inhibitory properties of whey protein di- gests: concentration and characterization of active pep- tides显示文摘 | ANNE P L PAIVI K KATI P | 2000 | J Dairy Res2000，67，： | 1 |
| 14 | The role of transbronehial needle aspiration in the diagnosis of peripheral lung masses or nodules显示文摘 | Katis K Inglesos E Zaehariadis E | 1995 | Eur Respir J1995，8，： | 1 |
| 15 | Analysis of polycyclic aromatic hydrocarbons in soil and sediment with on-line coupled pressurised hot water extraction,hollow fibre microporous membrane liquid-liquid extraction and gas chromatography显示文摘 | Kati K Tuulia H Kari H | 2003 | Analyst2003，128，： | 1 |
| 16 | Chromosomal translocations are a common phenomenon in Arabidopsis thaliana T-DNA in- sertion lines 显示文摘 | Katie A C Patrick J K | 2010 | The Plant Journal2010，64，6： | 1 |
| 17 | 显示文摘 | SPENCE R A KATI W M ANDERSON K S | 1995 | Science1995，267，： | 1 |
| 18 | The effects of intravenousdexmedetomindine on spinal hyperbaric ropivacaine anesthesia显示文摘 | Elcicek K Tekin M Kati I | 2010 | J Anesth2010，24，4： | 1 |
| 19 | Effects of foot- and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-golgi transport显示文摘 | KATY M GARETH H CAROLINE K | 2005 | J Virol2005，79，7： | 1 |
| 20 | Isolation of flavonoids from aspen knotwood by pressurized hot water extraction and comparison with other extraction techniques显示文摘 | HARTONEN K PARSHINTSEV J KATI S | 2007 | Talanta2007，74，1： | 1 |
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