|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Angiotensin Blockade and Progressive Loss of Kidney Function in Hemodialysis Patients: A Randomized Controlled Trial显示文摘 | Krista Dybtved Kjaergaard Christian Daugaard Peters Bente Jespersen Ida N?rager Tietze Jens Kristian Madsen Birgitte Bang Pedersen Marija Kristina Novosel Kathrine Skaaning Laursen Bo Martin Bibby Charlotte Strandhave Jens Dam Jensen | 2014 | American Journal of Kidney Diseases2014，，： | 1 |
| 2 | Avoidance behavior in cod (Gadus morhua) to a bottom-trawling vessel显示文摘 | Handegard N O Kathrine M Dag T | 2003 | Aquatic Living Resources2003，16，： | 1 |
| 3 | Triose phosphate export from chloroplasts and cellular sugar content regulate anthocyanin biosynthesis during high light acclimation显示文摘Plants have evolvedmultiple strategies to cope with rapid changes in the environment.During high light(HL)acclimation,the biosynthesis of photoprotective flavonoids,such as anthocyanins,is induced.However,the exact nature of the signal and downstreamfactors forHL induction of flavonoid biosynthesis(FB)is still under debate.Here,we show that carbon fixation in chloroplasts,subsequent export of photosynthates by triose phosphate/phosphate translocator(TPT),and rapid increase in cellular sugar content permit the transcriptional and metabolic activation of anthocyanin biosynthesis during HL acclimation.In combination with genetic and physiological analysis,targeted and whole-transcriptome gene expression studies suggest that reactive oxygen species and phytohormones play only a minor role in rapid HL induction of the anthocyanin branch of FB.In addition to transcripts of FB,sugar-responsive genes showed delayed repression or induction in tpt-2 during HL treatment,and a significant overlapwith transcripts regulated by SNF1-related protein kinase 1(SnRK1)was observed,including a central transcription factor of FB.Analysis of mutants with increased and repressed SnRK1 activity suggests that sugar-induced inactivation of SnRK1 is required for HL-mediated activation of anthocyanin biosynthesis.Our study emphasizes the central role of chloroplasts as sensors for environmental changes as well as the vital function of sugar signaling in plant acclimation. | Max-Emanuel Zirngibl Galileo Estopare Araguirang Anastasia Kitashova Kathrin Jahnke Tobias Rolka Christine Kühn Thomas Nägele Andreas S.Richter | 2023 | Plant Communications2023，4，1： | 1 |
| 4 | Genomic amplification of the human telomerase gene( TERC )in pap smears predicts the development of cervical caneer显示文摘 | Kerstin Heselmeyer - Haddad Kathrin Sommerfeld N | 2005 | Am J Pathology2005，166，4： | 1 |
| 5 | Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex:a dose-finding and safety study显示文摘 | Iben F S Kathrine N Per Bo L | 2006 | Anesthesiology2006，104，4： | 1 |
| 6 | Tracking the bioreduction of disulfide-containing cationic dendrimers 显示文摘 | Briilisauer L Kathriner N Prenrecaj M | 2012 | Angew Chem lnt Ed Engl2012，51，12： | 1 |
| 7 | Facebook and Online Privacy : Attitudes, Be- haviors, and Unintended Consequences显示文摘 | Debatin Bernhard Lovejoy Jennette P Ann- Kathrin Horn MA Hughes Brittany N | 2009 | Joumalof Computer- Mediated Communication2009，，15： | 1 |
| 8 | αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell–related features显示文摘 | Kathrin Held Latika Bhonsle-Deeng Katherina Siewert Wakiro Sato Eduardo Beltrán Stephan Schmidt Geraldine Rühl Judy K.M. Ng Peter Engerer Markus Moser Wolfgang E.F. Klinkert Holger Babbe Thomas Misgeld Hartmut Wekerle David-Axel Laplaud Reinhard Hohlfeld | 2015 | Neurology: Neuroimmunology & Neuroinflammation2015，，4： | 1 |
| 9 | BAF和PRC2复合物亚基Dpf2和Eed拮抗调控Tbx3控制胚胎干细胞分化显示文摘文章简介BAF(Brg or Brahma-associated factors)染色质重塑复合物利用其ATP酶亚基水解ATP产生的能量改变组蛋白和DNA的作用,调控转录因子同DNA的结合而调节基因的表达,参与多种生物学过程。BAF复合物由多至15个不同的亚基组成,但对这些亚基功能的研究多局限于显示失活特定亚基而导致的表型缺陷,缺乏深入的作用机制的研究。 | 张文胜 Constantinos Chronis Xi Chen Heyao Zhang Rapolas Spalinskas Mercedes Pardo Liangliang Chen Guangming Wu Zhexin Zhu Yong Yu Lu Yu Jyoti Choudhary Jennifer Nichols Mana MParast Boris Greber Pelin Sahle'n Kathrin Plath | 2020 | 科学新闻2020，，2： | 0 |
| 10 | 3.0T MR Coronary Angiography after Arterial Switch Operation for Transposition of The Great Arteries-Gd-FLASH Versus Non-Enhanced SSFP.A Feasibility Study显示文摘Background:Patency of the coronary arteries is an issue after reports of sudden cardiac death in patients with transposition of the great arteries(TGA)operated with arterial switch(ASO).Recent studies give rise to concern regarding the use of ionising radiation in congenital heart disease,and assessment of the coronary arteries with coronary MR angiography(CMRA)might be an attractive non-invasive,non-ionising imaging alternative in these patients.Theoretically,the use of 3.0T CMRA should improve the visualisation of the coronary arteries.The objective of this study was to assess feasibility of 3.0T CMRA at the coronary artery origins by comparing image quality with non-contrast CMRA in ASO TGA patients to healthy age-matched controls,and by comparing image quality with non-contrast CMRA to contrast enhanced CMRA in the patient group.Material and methods:Twelve patients,9-15 years(mean 11.9 years,standard deviation 1.5 years),and 12 age-matched controls(mean 12.7 years,standard deviation 1.7 years)were examined with 3D balanced steady-state free precession(SSFP).Nine of twelve patients had Gadolinium-enhanced fast low-angle shot(Gd-FLASH)performed after SSFP.Image quality at the coronary artery origins was evaluated subjectively with a 10 cm figurative visual analogue scale(fVAS)and objectively by signal-to-noise and contrast-to-noise ratio(SNR,CNR).Results:All,but one,coronary artery origins were identified.No significant difference in image quality scores was found between patients and controls with SSFP(mean values 6.5 cm—9.1 cm in patients and 7.0 cm—8.0 cm in controls,p-values>0.1).With SSFP,intra-observer fVAS mean score was 6.7 cm—8.6 cm and with Gd-FLASH 7.7 cm—8.7 cm.CNR was higher with Gd-FLASH(p<0.03).Intra-observer agreement index(AI)with SSFP was moderate-to-good(0.43–0.71)and with Gd-FLASH good(0.64–0.79)in all origins.Inter-observer AI was good in the left main stem(LMS)with SSFP(0.65).With Gd-FLASH inter-observer AI was good in LMS(0.78)and moderate(0.5)in the left anterior descending artery,but lacking in the other origins though with a good agreement on Bland-Altman plots.Conclusions:Our findings indicate a better,more reproducible image quality with Gd-FLASH than with non-contrast SSFP CMRA on 3.0T for evaluation of the coronary artery origins in ASO TGA children and adolescents. | Kathrine Rydén Suther Charlotte de Lange Henrik Brun Rolf Svendsmark Bac Nguyen Stig Larsen Bjarne Smevik Arnt Eltvedt Fiane Harald Lauritz Lindberg Einar Hopp | 2021 | Congenital Heart Disease2021，16，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员