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| 1 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 2 | Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease. | Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen | 2017 | World Journal of Gastroenterology2017，23，26： | 8 |
| 3 | Value of the quantity and distribution of subarachnoid haemorrhage on CT in the localization of a ruptured cerebral aneurysm显示文摘 | Jartti PH Ukkola VA | 2003 | Acta Neurochir2003，145，： | 1 |
| 4 | Embolization for the treastment of posterior epistaxis, An analysis of 31 cases显示文摘 | Siniluoto TM Leinonen AS Karttunen AL | 1993 | Arch Otolaryngol Head Neck Surg1993，119，： | 1 |
| 5 | Factors related to acute hydrocephalus atter subarachnoid hemorrhage 显示文摘 | Jartti P Karttunen A Jartti A | 2004 | Acta Radiol2004，45，3： | 1 |
| 6 | Expression of mRNA for interferon gamma, interleukin 10 and interleukin 12 (p40) in normal gastric mucosa and in mucosa infected with Helicobacter pylori显示文摘 | Karttunen RA Karttunrn TJ Yousfi MM | 1997 | Scand J Gastroenterol1997，32，： | 1 |
| 7 | Effect of Heat Denaturation on Beta-lactoglobulin-Induced Gastrointestinal Sensitization in Rats: Denatured β-LG Induces a More Intensive Local Immunologic Response than Native β-LG 显示文摘 | RYTKONEN J KARTTUNEN T J VALKONEN K H | 2002 | Pediatr Allergy Immunology2002，13，： | 1 |
| 8 | Binding of disordered proteins to a protein hub显示文摘 | Cino EA Killoran RC Karttunen M | 2013 | Sci Rep2013，3，： | 1 |
| 9 | Could Helicobater pylori infection increase the risk of coronary heart disease by modifying serum lipid concentration显示文摘 | Niemela S Karttunen T Korhonen T | 1996 | Heart1996，75，6： | 1 |
| 10 | Early rebleeding after coiling of ruptured intracranial aneurysms 显示文摘 | Jartti P Isokangas JM Karttunen A | 2010 | Acta Radiol2010，51，9： | 1 |
| 11 | Early rebleeding after coiling of ruptured intracranial aneurysms显示文摘 | Jartti P lsokangas JM Karttunen A | 2010 | Acta Radio12010，51，9： | 1 |
| 12 | Serrated adenocarcinoma of the rectum associated with perianal Paget's disease:a case report显示文摘 | Makinen JM Makinen MJ Karttunen TJ | 2002 | Histopathology2002，41，2： | 1 |
| 13 | Molecular dynamics simulations of lipid membranes with lateral force: rupture anddynamic properties 显示文摘 | XIE J Y DING G H KARTTUNEN M | 2014 | BBA-Biomembranes2014，1838，3： | 1 |
| 14 | Embolization forthe treastment of posterior epistaxis,An analysis of 31 cases显示文摘 | Siniluoto TM Leinonen AS Karttunen AL | 1993 | Arch Otolaryngol Head Neck Surg1993，119，： | 1 |
| 15 | Early rebleeding after coiling of ruptured intracranial aneurysms 显示文摘 | Jartti P Isokangas JM Karttunen A | 2010 | Acta Radiol2010，51，9： | 1 |
| 16 | Dielectrophoresis of nanocolloids: A molecular dynamics study显示文摘 | E. Salonen E. Terama I. Vattulainen M. Karttunen | 2005 | The European Physical Journal E2005，，2： | 1 |
| 17 | CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines显示文摘 | Wang Yu-fei Kelly CG Karttunen JT | 2001 | Immunity2001，15，6： | 1 |
| 18 | Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentration 显示文摘 | Niemela S Karttunen T Korhonen T | 1996 | Heart1996，75，3： | 1 |
| 19 | Antenna tests with a hologram-based CATR at 650 GH显示文摘 | Karttunen A Ala-Laurinaho J Vaaja M | 2009 | IEEE Transactions on Antennas and Propagation2009，57，3： | 1 |
| 20 | Ionic Surfactant Aggregates in Saline Solutions: Sodium Dodecyl Sulfate ( SDS) in the Presence of Excess Sodium Chloride ( NaCl) or Calcium Chloride ( CaCl2 )显示文摘 | Sammalkorpi M Karttunen M Haataja M | 2009 | J Phys Chem B2009，113，17： | 1 |
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