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| 1 | Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins显示文摘AIM: To examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreati- tis and to study how PAP gene expression correlates with severity of pancreatitis. METHODS: In vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo , pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAPⅠ, Ⅱ and Ⅲ were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score. RESULTS: In vitro, dexamethasone and IL-6 induced a marked transcription of PAPⅠ, Ⅱ and Ⅲ genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAPⅠ, Ⅱ or Ⅲ increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexa- methasone treatment, compared with saline treated ani- mals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05). CONCLUSION: Dexamethasone significantly decreases the severity of pancreatitis. The protective mechanism ofdexamethasone may be via upregulating PAP gene ex- pression during injury. | Emad Kandil Yin-Yao Lin Martin H Bluth Hong Zhang Gabriel Levi Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 2 | Pseudoatrophoderma colli in a male显示文摘 | Kanan MW Kandil E | 1969 | Br J Dermatol1969，81，1： | 1 |
| 3 | Synergistic inhibition of thy- roid cancer by suppressing MAPK/PI3K,/AKT pathways 显示文摘 | Kandil E Tsumagari K Ma J | 2013 | J Surg Res2013，184，2： | 1 |
| 4 | Transoral robotic- assisted thyroideetomy with central neck dissection: preelinical cadaver feasibility study and proposed surgical technique 显示文摘 | Richmon JD Holsinger FC Kandil E | 2011 | J Robot Surg2011，5，4： | 1 |
| 5 | Limiting shear creep of epoxy adhesive at the FRP-concrete interface using muhi- walled carbon nanotubes显示文摘 | Soliman E Kandil U F Taha M R | 2012 | Intemational Journal of Adhesion and Adhesives2012，33，： | 1 |
| 6 | Motor and sensory branching of the recurrent laryngeal nerve in thy- roid surgery显示文摘 | Kandil E Abdelghani S Friedlander P | 2011 | Surgery2011，150，6： | 1 |
| 7 | Recurrent la- ryngeal nerve:significance of the anterior extralaryngeal branch显示文摘 | Kandil E Abdel Khalek M Aslam R | 2011 | Surgery2011，149，6： | 1 |
| 8 | The impact of surgical vol-ume on patient outcomes following thyroid surgery 显示文摘 | Kandil E Noureldine SI Abbas A | 2013 | Surgery2013，154，6： | 1 |
| 9 | Long-term load forcasting for fast developing utility using a knowledge based exert system显示文摘 | El-Debeiky S M Hasanien N E | 2002 | IEEE Transaction on Power Systems2002，17，2： | 1 |
| 10 | Overview and comparison of long-term forecasting techniques for a fast developing utility显示文摘 | Kandil M S Debeiky S M Hasanien N E | 2001 | Electric Power Systems Research2001，58，1： | 1 |
| 11 | B-type natriuretic peptide:a biomarker for the diagnosis and risk stratification of patients with septic shock显示文摘 | Kandil E Burack J Sawas A | 2008 | Arch Surg2008，143，3： | 1 |
| 12 | The implementation of long term forecasting strategies using a knowledge based expert system显示文摘 | Kandil M S Debeiky S M Hasanien N E | 2001 | Electric Power Systems Research2001，58，1： | 1 |
| 13 | Composition ofa ch- emopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl Pho- rbol-β-aeetate (TPA) induced ornithine decarboxylase (ODC) activity显示文摘 | Kandil F E Smith M A L Rogers R B | 2002 | Journal of Agricultural and Food Chemistry2002，50，5： | 1 |
| 14 | Long-term load forecasting for fast developing utility using a knowledge- based expert system 显示文摘 | Kandil M S EI-Debeiky S M Hasanien N E | 2002 | IEEE Trans onPower Systems2002，17，2： | 1 |
| 15 | Long-term load forecasting for fast developing utility using a knowledge-based expert system显示文摘 | Kandil M S El-Debeiky S M Hasanien N E | 2002 | IEEE Transaction on Power Systems2002，17，2： | 1 |
| 16 | Primary hyperparathyroidism 显示文摘 | Felger EA Kandil E | 2010 | Otolaryngol Clin North Am2010，43，2： | 1 |
| 17 | B-Type natriuretic peptide: a biomarker for the diagnosis and risk stratification of patients with septic shock显示文摘 | Kandil E Burack J Sawas A | 2008 | Arch Surg2008，143，3： | 1 |
| 18 | Overview and comparison of long-term forecasting techniques for a fast developing utility:Part I显示文摘 | El-Debeiky S M Hasanien N E | 2001 | Electric Power Systems Research2001，58，1： | 1 |
| 19 | Long -termload forecasting for fast developing utility using a knowl-edge-based expert system 显示文摘 | Kandil M S El -Debeiky S M Hasanien N E | 2002 | IEEE Trans on Power Sys-tems2002，17，2： | 1 |
| 20 | Shoulder pain following laparoscopic cholecystectomy; factors affecting the incidence and severity 显示文摘 | Kandil TS El Hefnawy E | 2010 | J Laparoendosc Adv Surg Tech A2010，20，8： | 1 |
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