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| 1 | Enhanced myocardial fluorodeoxyglucose uptake following Adriamycin-based therapy: Evidence of early chemotherapeutic cardiotoxicity?显示文摘AIM: To analyze changes in myocardial glucose metabolism using fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients treated with adriamycin and to investigate the clinical significance of these changes.METHODS: Considering that FDG-PET scanning has the ability to show changes in glucose metabolism in the myocardium, we retrospectively analyzed the FDGPET studies of 18 lymphoma patients treated with adriamycin-based chemotherapy in both the preand posttherapy setting. Cardiac contractile parameters such as left ventricular ejection fraction were not available for correlation in all patients due to the short duration and the level of cumulative dose administered in these patients during the time of the follow-up FDG-PET study. The change in myocardial glucose utilization was estimated by change in standard uptake values (SUV) in the myocardium.RESULTS: We observed a significant change in SUVmean values in the myocardium (defined as more than change in cardiac SUVmean between pre-and post-chemotherapy PET) in 1 patients, whereas 6 patients did not show any significant cardiac FDG uptake in both preand post-therapy PET scans. Patients were divided into three groups based on the changes observed in myocardial tracer uptake on the followup 18 F-FDG-PET study. Group A (n = 8): showed an increase in cardiac 18 F-FDG uptake in the post-therapy scan compared to the baseline scan carried out prior to starting adriamycin-based chemotherapy. Group B (n = 6): showed no significant cardiac 18 F-FDG uptake in post-therapy and baseline PET scans, and group C (n = 4): showed a fall in cardiac 18 F-FDG uptake in the posttherapy scan compared to the baseline scan. Mean cumulative adriamycin dose (in mg/m 2 ) received during the time of the follow-up FDG-PET study was 256. 25, 250 and 137.5, respectively.CONCLUSION: Our study shows three different trends in the change in myocardial glucose metabolism in patients undergoing adriamycin-based chemotherapy. A further prospective study with prolonged follow-up of ventricular function is warranted to explore the significance of enhanced FDG uptake as a marker of early identification of adriamycin-induced cardiotoxicity. | Chaitanya Borde Purushottam Kand Sandip Basu | 2012 | World Journal of Radiology2012，4，5： | 9 |
| 2 | WSS45, a sulfated a-D-glucan, strongly interferes with Dengue 2 virus infection in vitro显示文摘 | Xian-kun TONG Hong QIU Xin ZHANG Li-ping SHI Gui-feng WANG Fei-hong JI Hui-yong DING Wei TANG KanDING Jian-ping ZUO | 2010 | Acta Pharmacologica Sinica2010，31，5： | 2 |
| 3 | Computer analysis of induced-inversion layer MOS solar cells显示文摘 | Yeh D Kand DeMassa T A | 1984 | Solid-State Electronics1984，27，3： | 2 |
| 4 | Segmentation of vessels in fundus images using spatiallly weighted fuzzy c-means clustering algorithm 显示文摘 | Kande G B Savithri T S Subbaiah P V | 2007 | International Journal of Computer Science and Network Security2007，7，12： | 1 |
| 5 | Impact of FDG-PET and -PET/CT imaging in the clinical decision-making of ovarian carcinoma: an evidence-based approach显示文摘 | Vandana Kumar Dhingra Purushottam Kand Sandip Basu | 2012 | Women’s Health2012，，： | 1 |
| 6 | Information-theoretic fuzzy approach to data reliability and data mining显示文摘 | Maimon O Kanded A Last M | 2001 | Fuzzy Sets and Systems2001，117，： | 1 |
| 7 | Impaired angiogenesis in aging kidney: potential role of VEGF and TSP-1 in renal disease显示文摘 | Kand D H Anderson S Kim Y G | 2001 | Am J Kid Dis2001，37，3： | 1 |
| 8 | Inhaled fluti- casone propionate reduces postoperative sore throat, cough, and hoarseness 显示文摘 | Tazeh - Kand NF Eslami B Mohammadian K | 2010 | Anesthesia and analgesia2010，111，4： | 1 |
| 9 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracelluler matrix显示文摘 | Poltorak Z Cohen T Sivan R Kandelis Y | 1997 | Biol Chem1997，272，11： | 1 |
| 10 | Inhaled fluticasone proplonate reduces postoperative sore throat, cough, and hoarseness 显示文摘 | Tazeh- Kand NF Eslami B Mohammadian KAnesth Analg | 2010 | Anesth Analg2010，111，4： | 1 |
| 11 | Physical factors influencing decomposition of organic materials in soil aggregates显示文摘 | Adu J Kand J M | 1978 | Soil Biology and Biochemistry1978，10，： | 1 |
| 12 | Effect of anionic salts in prepartum diets based on alfalfa显示文摘 | Joyce P W Sanchez W Kand G J P | 1997 | J Dairy Sci1997，80，11： | 1 |
| 13 | Monitoring of antioxidant properties of uric acid in humans for a consideration measuring of levels of allantoin in plasma by liquid chromatography 显示文摘 | Kand' ar R Zdkovd P Muzdkovd V | 2006 | Clin Chim Acta2006，365，6： | 1 |
| 14 | Reasonability of MC/DC for safetyrelevant software implemented in programming languages with short-circuit evaluation 显示文摘 | Kand| S Chandrashekar S | 2015 | Computing2015，97，3： | 1 |
| 15 | Certain faects of fluoride action on collagen protain in osseous and nonoffeous tissues显示文摘 | Kand sharma YD | 1982 | Fluoride1982，15，4： | 1 |
| 16 | Sign-changing solutions for elliptic equations with critical Sobolev-Hardy exponents显示文摘 | Kand D Peng S | | J Math Anal Appl0，291，2： | 1 |
| 17 | Transiton to an irreversible state of senescenence in HeLa cells arrested by repression of HPV E6 and E7 genes 显示文摘 | KAND H T LEE C J SEO E J | 2004 | Mech Ageing2004，125，1： | 1 |
| 18 | Deficiency of guelatinase A sup-presses smooth muscle cell invasion and development of experimental intimal hyperplasia显示文摘 | Kuzuya M Kand S Sasaki T | 2003 | Circulation2003，108，： | 1 |
| 19 | Heterogeneous soil water flow and maeropores described with combined tracers of dye and iodine显示文摘 | Wang Kand Zhang Renduo | 2011 | Journal of Hydrology2011，397，1： | 1 |
| 20 | Biofilters:flexible,reliable bio- logical reactors显示文摘 | R Pujol M Hamonl X Kande | 1994 | Water Science and Technology1994，29，1011： | 1 |
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