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| 1 | Aeroservoelastic modeling and analysis of a canard-configured air-breathing hypersonic vehicles显示文摘Air-breathing hypersonic vehicles (HSVs) are typically characterized by interactions of elasticity, propulsion and rigid-body flight dynamics, which may result in intractable aeroservoelastic problem. When canard is added, this problem would be even intensified by the introduction of low-frequency canard pivot mode. This paper concerns how the aeroservoelastic stability of a canard-configured HSV is affected by the pivot stiffnesses of all-moveable horizontal tail (HT) and canard. A wing/pivot system model is developed by considering the pivot torsional flexibility, fuselage vibration, and control input. The governing equations of the aeroservoelastic system are established by combining the equations of rigid-body motion, elastic fuselage model, wing/pivot system models and actuator dynamics. An unsteady aerodynamic model is developed by steady Shock-Expansion theory with an unsteady correction using local piston theory. A baseline controller is given to provide approximate inflight characteristics of rigid-body modes. The vehicle is trimmed for equilibrium state, around which the linearized equations are derived for stability analysis. A comparative study of damping ratios, closed-loop poles and responses are conducted with varying controller gains and pivot stiffnesses. Available bandwidth for control design is discussed and feasible region for pivot stiffnesses of HT and canard is given. | Zeng Kaichun Xiang Jinwu Li Daochun | 2013 | Chinese Journal of Aeronautics2013，26，4： | 7 |
| 2 | The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma显示文摘 | Liu Hong Yu Han Hongwei Zhang Mengbin Li Taiqian Gong Li Sun Kaichun Wu Qingchuan Zhao Daiming Fan | 2010 | Annals of Surgery2010，，6： | 3 |
| 3 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 4 | Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis显示文摘 | Shengjun Wu Bin Feng Kai Li Xia Zhu Shuhui Liang Xufeng Liu Shuang Han Biaoluo Wang Kaichun Wu Danmin Miao Jie Liang Daiming Fan | 2012 | The American Journal of Medicine2012，，6： | 2 |
| 5 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 6 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 7 | MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN显示文摘 | Fang Wang Ting Li Bin Zhang Hong Li Qiong Wu Li Yang Yongzhan Nie Kaichun Wu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 8 | USP33, a new player in lung cancer, mediates Slit-Robo signaling显示文摘Ubiquitin 特定的朊酶(USP33 ) 33 是调整多样的细胞的过程的多功能的蛋白质。在肺癌症的 USP33 的表示和角色仍然保持未经勘探。在这研究,我们证明 USP33 在肺癌症病人的多重队是下面调整的, USP33 的那低表情与差的预后被联系。USP33 调停 Slit-Robo 在肺癌症房间移植发信号。USP33 的 Downregulation 在肺癌症房间减少 Robo1 的蛋白质稳定性,提供为在调停的 USP33 功能的以前未知的机制在肺癌症房间的裂缝活动。一起拿, USP33 是在调整 Slit-Robo 发信号的肺癌症的一个新播放器。我们的数据建议 USP33 可以作为一个预示的标记是为有潜力的肺癌症的候选人肿瘤 suppressor。 | Pushuai Wen Ruirui Kong Jianghong Liu Li Zhu Xiaoping Chen Xiaofei Li Yongzhan Nie Kaichun WU Jane Y. Wu | 2014 | Protein & Cell2014，5，9： | 2 |
| 9 | Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation显示文摘 | Feihu Bai Xinning Guo Li Yang Jun Wang Yongquan Shi Faming Zhang Huihong Zhai Yuanyuan Lu Huahong Xie Kaichun Wu Daiming Fan | 2007 | Digestive Diseases and Sciences2007，，6： | 1 |
| 10 | Osteopontin Contributes to TGF-β1 Mediated Hepatic Stellate Cell Activation显示文摘 | Xiao Xiao Yi Gang Yong Gu Lina Zhao Jindong Chu Jinfeng Zhou Xiqiang Cai Hui Zhang Li Xu Yongzhan Nie Kaichun Wu Zhiguo Liu Daiming Fan | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 11 | Functional identification of lncRNAs in sweet cherry(Prunus avium)pollen tubes via transcriptome analysis using single-molecule long-read sequencing显示文摘Sweet cherry(Prunus avium)is a popular fruit with high nutritional value and excellent flavor.Although pollen plays an important role in the double fertilization and subsequent fruit production of this species,little is known about its pollen tube transcriptome.In this study,we identified 16,409 transcripts using single-molecule sequencing.After filtering 292 transposable elements,we conducted further analyses including mRNA classification,gene function prediction,alternative splicing(AS)analysis,and long noncoding RNA(lncRNA)identification to gain insight into the pollen transcriptome.The filtered transcripts could be matched with 3,438 coding region sequences from the sweet cherry genome.GO and KEGG analyses revealed complex biological processes during pollen tube elongation.A total of 2043 AS events were predicted,7 of which were identified in different organs,such as the leaf,pistil and pollen tube.Using BLASTnt and the Coding-Potential Assessment Tool(CPAT),we distinguished a total of 284 lncRNAs,among which 154 qualified as natural antisense transcripts(NATs).As the NATs could be the reverse complements of coding mRNA sequences,they might bind to coding sequences.Antisense transfection assays showed that the NATs could regulate the expression levels of their complementary sequences and even affect the growth conditions of pollen tubes.In summary,this research characterizes the transcripts of P.avium pollen and lays the foundation for elucidating the physiological and biochemical mechanisms underlying sexual reproduction in the male gametes of this species. | Yang Li Chuanbao Wu Chunsheng Liu Jie Yu Xuwei Duan Wenqi Fan Jing Wang Xiaoming Zhang Guohua Yan Tianzhong Li Kaichun Zhang | 2019 | Horticulture Research2019，6，1： | 1 |
| 12 | Diagnosis of at-rophic body gastritis in Chinese patients by measuring serum pepsinogen显示文摘 | Wu Kaichun Li Hongtao Qiao Taidong | 2004 | Chin J Dig Dis2004，5，1： | 1 |
| 13 | Akt1/protein Kinase Bα is Involved in Gastric Cancer Progression and Cell Proliferation显示文摘 | Zheyi Han Kaichun Wu Huiqin Shen Chunying Li Shuang Han Liu Hong Yongquan Shi Na Liu Changcun Guo Yan Xue Taidong Qiao Daiming Fan | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 14 | The malignant phenotype-associated microRNA in gastroenteric, hepatobiliary and pancreatic carcinomas显示文摘 | Liu Hong Yu Han Shujun Li Jianjun Yang Jianyong Zheng Hongwei Zhang Qingchuan Zhao Kaichun Wu Daiming Fan | 2010 | Expert Opinion on Biological Therapy2010，，12： | 1 |
| 15 | Detection of Serum Gastric Cancer-Associated MG7-Ag from Gastric Cancer Patients Using a Sensitive and Convenient ELISA Method显示文摘 | Bin Jin Xin Wang Yan Jin Wensen Xia Bei Chen Lin Liu Zheng Chen Liu Hong Wenqi Du Kun Yan Honghong Wang Donghong Yuan Xiaoli Hui Li He Faming Zhang Yunping Zhao Kaichun Wu Daiming Fan | 2009 | Cancer Investigation2009，，2： | 1 |
| 16 | Involvement of MGr1-Ag/37LRP in the vincristine-induced HIF-1 expression in gastric cancer cells显示文摘 | Lili Liu Xiaoxuan Ning Li Sun Yongquan Shi Shuang Han Changcun Guo Yu Chen Shiren Sun Fang Yin Kaichun Wu Daiming Fan | 2007 | Molecular and Cellular Biochemistry2007，，： | 1 |
| 17 | Cloning, characterization and expression of the gene encoding polygalacturonase-inhibiting proteins (PGIPs) of peach [ prunus persica (L.) Batch]显示文摘 | Fengshan Liang Kaichun Zhang Chunjiang Zhou Fanna Kong Jun Li Bin Wang | 2004 | Plant Science2004，，2： | 1 |
| 18 | Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer显示文摘 | Shanhong Tang Guitao Yang Yun Meng Rui Du Xiaohua Li Rui Fan Lina Zhao Qian Bi Jiang Jin Liucun Gao Lin Zhang Hao Li Meng Fan Yingmei Wang Kaichun Wu Jie Liu Daiming Fan | 2010 | Cancer Biology & Therapy2010，，： | 1 |
| 19 | The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma显示文摘 | Liu Hong Yu Han Hongwei Zhang Mengbin Li Taiqian Gong Li Sun Kaichun Wu Qingchuan Zhao Daiming Fan | 2010 | Annals of Surgery2010，，6： | 1 |
| 20 | Fecal microbiota transplantation is an effective rescue therapy for refractory inflammatory bowel disease显示文摘 | Bota Cui Pan Li Lijuan Xu Zhaoyuan Peng Youquan Zhao Huiquan Wang Zhi He Ting Zhang Guozhong Ji Kaichun Wu Daiming Fan Faming Zhang | 2015 | Inflammation and Cell Signaling2015，，： | 1 |
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