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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Behavior of concrete under biaxial stress 显示文摘 | Kupfer H Hilesdorf H K Rusch H | 1969 | ACI Structure Journals1969，66，2： | 2 |
| 3 | Behavior of concrete under biaxial stresses显示文摘 | KUPFER H B GERSTLE K H | 1973 | Journal of Engineering Mechanics Division ASCE1973，99，： | 1 |
| 4 | Behavior of concrete under biaxial stresses 显示文摘 | KUPFER H | 1969 | ACI Journal1969，66，8： | 1 |
| 5 | Behaviour of Concrete Under Biaxial Stress显示文摘 | Kupfer H H K Hilsdoff H Rüsch | 1969 | Journal of American Concrete Institute1969，66，8： | 1 |
| 6 | Behavior of concrete under biaxial stresses显示文摘 | Kupfer H Hilsdorf H K Rtisch H | 1969 | ACI Journal1969，66，8： | 1 |
| 7 | Three-dimensional segregation of supramolecular activation clusters in T cells 显示文摘 | Monks CR Freiberg BA Kupfer H | 1998 | Nature1998，395，6697： | 1 |
| 8 | Behavior of concrete under biaxial stress显示文摘 | KUPFER H HILESDORF H K RUSCH H | 1969 | ACI Journals1969，66，8： | 1 |
| 9 | Behavior of concrete under biaxial stresses 显示文摘 | Kupfer H Hilsdorf H K Rusch H | 1969 | ACI Journal1969，66，8： | 1 |
| 10 | Behavior of concrete under biaxial stresses显示文摘 | Kupfer H Hilsdorf H K Rusch H | 1969 | Journal of American Concrete Institute1969，66，： | 1 |
| 11 | Behavior of concrete under biaxial stresses显示文摘 | HILSDORF HK RUSCH H | 1969 | ACI Journal1969，66，8： | 1 |
| 12 | Behavior of concrete un-der biaxial stresses显示文摘 | Kupfer H Hilsdoif H K Rusch H | 1969 | American Concrete Institute Jour-nal1969，66，8： | 1 |
| 13 | Thin Solid Films显示文摘 | Richter F Kupfer H Schlott P Gessner T Kaufmann C | 2001 | 389( 1-2 ):2782001，389，12： | 1 |
| 14 | Behavior of concrete under biaxial stresses 显示文摘 | Kupfer H B Hilsdorf H K Rusch H | 1969 | Journal of the American Concrete Institute1969，66，8： | 1 |
| 15 | Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants 显示文摘 | Bulger W H Vernon J F Kupfer D 1985 | 1985 | Mol Pharmacol1985，27，： | 1 |
| 16 | Behavior of concrete under biaxial stresses显示文摘 | Kupfer H B Hilsdorf H K Rusch H | 1969 | ACI Journal1969，66，8： | 1 |
| 17 | Selective modulation of proteinkinase C-during T-cell activation显示文摘 | Monks CR Kupfer H Tamir I | 1997 | Nature1997，385，6611： | 1 |
| 18 | Behavior of concrete under biaxial stresses显示文摘 | Kupfer H Hilsdorf H K Rusch H | 1969 | Journal of ACI1969，66，8： | 1 |
| 19 | Behavior of concrete under biaxial stresses 显示文摘 | Kupfer H Hilsdorf H K Rusch H | 1969 | ACI Journal1969，66，8： | 1 |
| 20 | Role of hepaticmonooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants显示文摘 | Bulger W H Vernon J F Kupfer D | 1985 | Mol Pharmacol1985，27，： | 1 |
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