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	题名	作者	年代	出处	被引量
1	脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。	Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊	2018	神经损伤与功能重建2018，13，4：	4
2	IgG4-related lung and pleural disease:a clinicopathologic study of 21 cases显示文摘	Zen Y Inoue D Kitao A	2009	Am J Surg Pathol2009，33，：	1
3	The uptake trans?porter OATP8 expression decreases during multistep hepato?carcinogenesis: correlation with gadoxetic acid enhanced MR imaging显示文摘	KITAO A MATSUI 0 YONEDA N	2011	Eur Radiol2011，21，10：	1
4	Hypervascular hepatoce\|lular carcinomas showing hyperintensity on hepatobiliary phase of ga doxetic acid-enhanced magnetic resonance imaging: a possible sub type with mature hepatocyte nature显示文摘	Yoneda N Matsui O Kitao A	2013	Jpn J Radiol2013，31，7：	1
5	Variation in photoinhibition among Sasa senanensis, Quercus mongolica, and Acer mono in the understory of a deciduous broad-leaved forest exposed to canopy gaps caused by typhoons 显示文摘	TOBITA H UTSUGI H KITAO M KAYAMA M UEMURA A KITAOKA S MARUYAMA Y	2010	Trees-Structure and Function2010，24，2：	1
6	FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway显示文摘	Ishiai M Kitao H Smogorzewska A	2008	Nat Struct Mol Biol2008，15，11：	1
7	Mutations in RECQL4 cause a subset of cases of Rothmund-Thomwon syndrome显示文摘	Shimamoto A Goto M	1999	Nature Genet1999，22，1：	1
8	Endothelial tQ mesenchymal transition via transforming growth factor-( 1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension 显示文摘	KITAO A SATO Y SAWADA-KITAMURA S	2009	Am J Pathol2009，175，2：	1
9	Endothelial tomesenchymal transition via transforming growth factor-betal/Smad activation is associated with portal venousstenosis in idiopathic portal hypertension 显示文摘	Kitao A Sato Y Sawada-Kitamura S	2009	Ame JPathol2009，175，2：	1
10	Mutations in RECQIA cause a subset of cases of Rothmund-Thomson syn- drome显示文摘	KITAO S SHIMAMOTO A GOTO M	1999	Nature Genetics1999，22，1：	1
11	Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line显示文摘	Ogino A Kitao H Hirano S	2007	Cancer Res2007，67，16：	1
12	Hepatocytetransporter expression in FNH and FNH -like nodule :correlation with signal intensity on gadoxetic acidenhanced magnetic resonance images 显示文摘	Yoneda N Matsui 0 Kitao A	2012	Jpn J Radiol2012，30，6：	1
13	A unique human gene that spans over 230 kb in thehuman chromosome 8p11-12 and codes multiple family proteins sharing RNA-bindingmotifs显示文摘	Shimamoto A Kitao S Ichikawa K	1996	Proc Natl Acad Sci USA1996，93，10：	1
14	The effects of solvent on the confor-mation and the collective motions of protein:normal modeanalysis and molecular dynamics simulations of melittin in wa-ter and in vacuum显示文摘	Kitao A Hirata F Go N	1991	Chem Phys1991，158，23：	1
15	Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging-correlation with molecular transporters and histopathologic features 显示文摘	Kitao A Zen Y Matsui O	2010	Radiology2010，256，：	1
16	Mutations in REC- QL4 cause a subset of cases of Rothmund - Thomson syndrome 显示文摘	Kitao S Shimamoto A Goto M	1999	NatGenet1999，22，：	1
17	A random-ized placebo-controlled, double-blind study of aprepitant innondrinking women younger than 70 years receiving moderatelyemetogenic chemotherapy 显示文摘	TANIOKA M KITAO A MATSUMOTO K	2013	Br J Cancer2013，109，4：	1
18	lgG4-related lung and pleural disease: a elinieopathologie study ot 21 eases 显示文摘	Zen Y lnoue I) Kitao A	2009	Am J Surg Patho12009，33，12：	1
19	The uptake transporter OATP8 expression decreases during muhistep hepatocarcinngenesis:correla- tion with gadoxetic acid enhanced MR imaging 显示文摘	Kitao A Matsui O Yoneda N	2011	Eur Radiol2011，21，：	1
20	Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line显示文摘	Ogino A Kitao H Hirano S	2007	Cancer Res2007，67，16：	1

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