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		题名	作者	年代	出处	被引量
	1	Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources.	Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames	2014	World Journal of Diabetes2014，5，2：	13
	2	Internationally distributed frozen oyster meat causing multiple outbreaks of norovirus in fection in Australia显示文摘	Webby RJ Carville KS Kirk MD	2007	Clin Infect Dis2007，44，：	1
	3	Internationally distributedfrozen oyster meat causing multiple outbreaks of norovims infection in Australia显示文摘	Webby RJ Carville KS Kirk MD	2007	Clin Infect Dis2007，，：	1
	4	Does preoperative computed tomography scanning aid assessment of oseophagel carcinoma显示文摘	Kirk SJ Moorhead RJ McIlrath E	1990	Postgrad Med J1990，66，773：	1
	5	Isdahl Metal Prevalence of hyperdastic Articular Pillars in the Cervical Spine and Re-lationship with Cervical Lordosis显示文摘	PETERSON CK KIRK RJ	1999	J ManipulativePhysiol Ther(S0161-4754)1999，22，6：	1
	6	Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3 13 显示文摘	Kirk JA Holewinski RJ Kooij V	2014	J Clin Invest2014，124，1：	1
	7	Internationally distributed frozen oyster meat causing multiple outbreaks of norovirus infection in Australia显示文摘	Webby RJ Carville KS Kirk MD	2007	Clin Infect Dis2007，44，8：	1
	8	Accurate whole human genome sequencing using reversible terminator chemistry显示文摘	Bentley DR Balasubramanian S Swerdlow HP Smith GP Milton J Brown CG Hall KP Evers DJ Barnes CL Bignell HR Boutell JM Bryant J Carter RJ Keira Cheetham R Cox AJ Ellis DJ Flatbush MR Gormley NA Humphray SJ Irving LJ Karbelashvili MS Kirk SM Li H Liu X Maisi		0，，：	1
	9	Internationally distributed froxen oyster meat causing mulitple outbreaks of norovims infection in Australia显示文摘	Webby RJ Garville KS Kirk MD	2007	Clin Infect Dis2007，44，8：	1
	10	Cell volume control in the Plasmodium-infected erythrocyte显示文摘	Allen RJ Kirk K	2004	Trends Parasitol2004，20，：	1
	11	Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3beta显示文摘	Kirk JA Holewinski RJ Kooij V	2014	J Clin Invest2014，124，1：	1
	12	Internationally distributed frozen oyster meat causing multiple outbreaks of norovirus infection in Australia 显示文摘	Webby RJ Carville KS Kirk MD	2007	Clin J Infect Dis2007，44，8：	1
	13	Isdahl Metal Prevalence of hyperdastic Articular Pillars in the Cervical Spine and Relationship with Cervical Lordosis显示文摘	PETERSON CK KIRK RJ	1999	J Manipulative Physiol Ther(S0161-4754)1999，22，6：	1
	14	Acid extrusion from the intraeryth- rocytic malaria parasite is not via a Na+/H+ exchanger显示文摘	Spillman N J Allen RJ Kirk K	2008	Mol Bio- chem Parasitol2008，162，1：	1
	15	Prevalence of hyperplastic articular pillars in the cervical spine and relationship with cervical lordosis显示文摘	Peterson CK Kirk RJ Isdahl M	1999	Manipulative Physiol Ther1999，22，6：	1

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