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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | 用RFLP方法研究陕西省主要小麦品种遗传多样性及其演变显示文摘研究用RFLP方法,对我国主要小麦产区,陕西省40年代以来广为种植的小麦品种的遗传多样性进行了研究,结果表明,占总带数26.2%的HINDII酶的RFLP带具有遗传多态性。24个小麦品种平均遗传相似系数为0.948。53.8%的探针显示了多态性。平均多态性信息含量指数为0.252。陕西省小麦品种遗传多样性以70年代为最高,之后开始降低。 | 朱列层 唐国顺 HAZEN S P KIM H S WARD R W | 1999 | 西北植物学报1999，19，2： | 11 |
| 3 | 室内TDR试验监测石灰矿渣加固粘性土的物理化学反应过程(英文)显示文摘石灰矿渣和水泥矿渣常用于加固道路基层的粘性土。目前现场一般采用未加固土的最大干密度和最优含水率来评价加固土的压实施工质量。但是粘性土掺加了石灰后,发生了复杂的物理化学反应,使得其压实特性与未加固土有很大的不同。采用时域反射计监测石灰加固土内的物理化学反应过程。试验时将不同石灰矿渣掺和量和含水率的Orchard粘土通过标准击实试验夯实于击实筒中,用TDR监测其中的物理化学反应,针式贯入仪监测强度的增长。试验发现,电导率和介电常数的变化反应了土中的离子交换和硬化反应的过程。初始电导率(1d之内)的减小揭示了石灰矿渣的掺和量的大小,而长期电导率的减小揭示了强度的增长。试验表明,时域反射计技术可用于评价石灰加固土的施工质量。 | 陈仁朋 DAITA R K DRNEVICH V P KIM D H | 2006 | 岩土工程学报2006，28，2： | 7 |
| 4 | Physiological thermoregulation in bigeye tuna, Thunnus obesus 显示文摘 | Kim N H John R S | 1994 | Environmental Biology of Eishers1994，40，： | 2 |
| 5 | Human osteoblast response in vitro to platelet-derived growth factor and transforming growth factor-beta delivered from controlled-release polymer rods显示文摘 | Kim H D Valentini R F | 1997 | Biomaterials1997，18，17： | 2 |
| 6 | Gas absorption with filled polymer systems显示文摘 | L Chen H Sheth R Kim | 2001 | Polymer Engineering and Science2001，41，6： | 2 |
| 7 | Nonlinear dynamics,delay times,and embedding windows显示文摘 | Kim H S Eykholt R Salas J D | | 0，，1： | 2 |
| 8 | Nonlinear dynamics, delay times, and embedding windows显示文摘 | Kim H S Eykholt R Salas J D | 1999 | Physica D1999，127，： | 2 |
| 9 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 10 | Unique gene expression program of human germinal center T helper cells 显示文摘 | Kim C H Lim H W Kim J R | 2004 | Blood2004，104，7： | 1 |
| 11 | A Multidimensional Trust Formation Model in B-to-C Ecommerce:A Conceptual Framework and Content Analyses of Academia/Practitioner Perspectives 显示文摘 | Kim D J Song Y I Braynov S B Rao H R | 2005 | Decision Support Systems2005，40，2： | 1 |
| 12 | A study of magnetic and optical properties of Cu-doped ZnO 显示文摘 | LEE H J KIM B S CHO C R | 2004 | Phys Status Solidi B2004，241，7： | 1 |
| 13 | Molecular biology of cervical myelopathy and spinal cord injury:role of oligodendrocyte apoptosis显示文摘 | Kim D H Vaccaro A R Henderson F C Benzel E C | 2003 | Spine J2003，3，： | 1 |
| 14 | Preparation of platinum- doped hollow spheres and their electrocatalytic activity in water electrolysis 显示文摘 | Kim H R Chattopadhyay J Son J I | 2008 | Korean Journal of Chemical Engineering2008，25，4： | 1 |
| 15 | Use of a photocatalytic membrane reactor for the removal of natural organic matter in water: effect of photoinduced desorption and ferrihydrite adsorption显示文摘 | CHOO K H TAO R KIM M J | 2008 | J Membr Sci2008，322，： | 1 |
| 16 | Performance of tin doped titania hollow spheres as electrocatalysts for hydrogen and oxygen production in water electrolysis显示文摘 | CHATTOPADHYAY J KIM H R MOON S B | 2008 | International Journal of Hydrogen Energy2008，33，13： | 1 |
| 17 | Fabrication of homostructure ZnO p-n junctions显示文摘 | Kim W J White H M | 2000 | J Cryst Growth2000，219，： | 1 |
| 18 | Approximation of contact stress for a compressed and laterally one side restrained O - ring 显示文摘 | Lee Y H Kim D R Kim H K | 2007 | Engineering Failure Analysis2007，14，8： | 1 |
| 19 | Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells显示文摘 | KANG G Y LEE E R KIM J H | 2009 | Eur J Pharmacol2009，611，13： | 1 |
| 20 | Effect of river landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes(ARG)显示文摘 | PEI R KIM S C CARLSON K H PRUDEN A | 2006 | Water Res2006，40，12： | 1 |
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