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| 1 | Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer. | Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC–MAPK signaling pathway显示文摘 | Vivian Soetikno Flori R. Sari Vijayakumar Sukumaran Arun Prasath Lakshmanan Sayaka Mito Meilei Harima Rajarajan A. Thandavarayan Kenji Suzuki Masaki Nagata Ritsuo Takagi Kenichi Watanabe | 2012 | European Journal of Pharmaceutical Sciences2012，，3： | 2 |
| 3 | Prognostic significance of the co?overexpression of fibroblast growthfactor receptors 1, 2 and 4 in gastric cancer显示文摘 | Hideaki Murase Mikito Inokuchi Yoko Takagi Keiji Kato Kazuyuki Kojima Kenichi Sugihara | 2014 | Molecular and Clinical Oncology2014，，4： | 2 |
| 4 | Methylation of BNIP3 and DAPK indicates lower response to chemotherapyand poor prognosis in gastric cancer显示文摘 | Hirofumi Sugita Satoru Iida Mikito Inokuchi Keiji Kato Megumi Ishiguro Toshiaki Ishikawa Yoko Takagi Megumu Enjoji Hiroyuki Yamada Hiroyuki Uetake Kazuyuki Kojima Kenichi Sugihara | 2011 | Oncology Reports2011，，2： | 2 |
| 5 | Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test显示文摘 | Masaki Kakimoto Hiroyuki Uetake Takayuki Osanai Yoshinori Shirota Yoko Takagi Emiko Takeshita Yoichi Toriya Kathleen Danenberg Peter V. Danenberg Kenichi Sugihara | 2004 | Cancer Letters2004，，1： | 1 |
| 6 | Effect of molybdenum and carbon on the properties of iron molybdenum boride hard alloys显示文摘 | Kenichi Takagi Tadao Watanable Teiichi Ando | 1986 | The Internationtal Journal of Powder Metallurgy1986，22，2： | 1 |
| 7 | Effect of Ni on the mechanical properties of Fe,Mo,boride hard alloys显示文摘 | Kenichi Takagi Masao Komai Tsuneyuki Ide | 1987 | The Internationtal Journal of Powder Metallurgy1987，23，3： | 1 |
| 8 | Effect of Ni on the mechanical properties of Fe,Mo,boride hard alloys显示文摘 | KENICHI Takagi MASAO Komai TSUNEYUKI Ide | 1987 | Int J Powder Metall1987，23，3： | 1 |
| 9 | Effect of molybdenum and carbon on the properties of iron molybdenum boride hard alloys显示文摘 | KENICHI Takagi TADAO Watanable TEIICHI Ando | 1986 | Int J Powder Metall1986，22，2： | 1 |
| 10 | Effect of classification based on combination of mutation and methylationin colorectal cancer prognosis显示文摘 | Haruhiko Aoyagi Satoru Iida Hiroyuki Uetake Toshiaki Ishikawa Yoko Takagi Hirotoshi Kobayashi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2011 | Oncology Reports2011，，3： | 1 |
| 11 | Effect of molybdenum and carbon on the properties of iron molybdenum boride hard alloys显示文摘 | Kenichi Takagi Tadao Watanable Teiichi Ando | 1986 | The Internationtal Journal of Powder Metallurgy1986，22，2： | 1 |
| 12 | Effect of molybdenum and carbon on the properties of iron molybdenum boride hard alloys 显示文摘 | Kenichi Takagi Tadao Watanable Teiichi Ando and Yoshikazu Kondo | 1986 | The Internationtal Journal of Powder Metallurgy1986，22，2： | 1 |
| 13 | Effect of Ni on the mechanical properties of Fe, Mo, boride hard alloys 显示文摘 | Kenichi Takagi Masao Komai Tsuneyuki Ide | 1987 | The Internationtal Journal of Powder Metallurgy1987，23，3： | 1 |
| 14 | Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypoxia-Inducible Factor (HIF-1α) Pathway, Angiogenic Factors Production and Poor Prognosis显示文摘 | Yanislav Kolev MD PhD Hiroyuki Uetake MD PhD Yoko Takagi Kenichi Sugihara MD PhD | 2008 | Annals of Surgical Oncology2008，，8： | 1 |
| 15 | Small-cell carcinoma of the extrahepatic bile duct: a case report and review of the literature显示文摘 | Kenichi Hosonuma Ken Sato Manabu Honma Kenji Kashiwabara Hitomi Takahashi Hitoshi Takagi Masatomo Mori | 2008 | Hepatology International2008，，1： | 1 |
| 16 | Effect of molybdenum and carbon on the properties of iron molybdenun boride hard alloys显示文摘 | Kenichi Takagi Tadao Watanable Teiichi Ando etal | 1986 | The International Journal of Powder Metallurgy1986，22，2： | 1 |
| 17 | Effect of Ni on the mechanical properties of Fe, Mo, boride bard alloys显示文摘 | Kenichi Takagi Masao Komai Tsuneyuki Ide | 1987 | The International Journal of Powder Metallurgy1987，23，3： | 1 |
| 18 | Relationship between microsatellite instability and telomere shortening in colorectal cancer显示文摘 | Dr. Sho Takagi M.D. Yoshitaka Kinouchi M.D. Nobuo Hiwatashi M.D. Fumio Nagashima M.D. Masaki Chida M.D. Seiichi Takahashi M.D. Kenichi Negoro M.D. Tooru Shimosegawa M.D. Takayoshi Toyota M.D | 2000 | Diseases of the Colon & Rectum2000，，10： | 1 |
| 19 | Effects of Mo/B atomic ratio on the mechanical properties and structure of Mo2NiB2 boride base cermets with Cr and V additions显示文摘 | Kenichi Takagi Yuji Yamasaki | 2000 | Journal of Solid State Chemistry2000，154，5： | 1 |
| 20 | Incidence, Mortality, and Predictive Factors of Hepatocellular Carcinoma in Primary Biliary Cirrhosis显示文摘 | Kenichi Hosonuma Ken Sato Masatoshi Yanagisawa Satoru Kakizaki Hitoshi Takagi Junko Hirato Masatomo Mori Bj?rn Moum | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
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