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30篇 您的检索式：作者名="KALKUNTE S"

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	题名	作者	年代	出处	被引量
1	Enhanced chemosensitivity of p73α gene transferred into H1299 cell line of human lung adenocarcinoma显示文摘Objective: To study the effects of transferred wild type p73α gene on the sensitivity to the chemotherapeutic agents and the growth of p53-null H1299 cells of human lung adenocarcinoma. Methods: The pcDNA3-HA-p73α plasmid was transferred into the cultured p53-null H1299 cells of human lung adenocarcinoma with the mediation of Dosper liposome; The cells resistant to G418 were selected. The expression of p73α gene in the cells was examined with Western blot. MTT assay was used to analyze the response of the transfected cells to cis-dichlorodiamine platinum (cDDP) and adriamycin (ADM). The rate of drug-induced apoptosis of the transfected cells was determined with flow cytometry and DNA fragmentation assay. The changes of the biological behaviors were observed with colony formation assay. Results: The transfected H1299 cells of human lung adenocarcinoma over-expressed p73α protein stably. MTT assay showed that the IC 50 values of cDDP and ADM were reduced by approximately 7 fold and 130 fold respectively in the transfected cells as compared with the untransfected ones. Lower concentration of the chemotherapeutic agents (1.25 μmol/L of cDDP and 0.05 μmol/L of ADM) could be employed to suppress markedly the growth of the transfected H1299 cells. The apoptotic rate induced by cDDP was increased from 10.1% to 38 4% (P<0.01) and that of ADM from 12.1% to 49.3% (P<0.01). The clonogenecity after the administration of chemotherapeutic agents was significantly lower in the transfected H1299 cells than in the parental cells (P<0.01). The sensitive enhancement ratios were 1.8 and 2.6 for cDDP and ADM respectively. Conclusion: The transfection of H1299 cells with wild type p73α gene results in an increase of the sensitivity of the cells to chemotherapeutic agents.	何勇范士志 Kalkunte S Srivenugopal 蒋耀光秦川	2004	Journal of Medical Colleges of PLA(China)2004，19，3：	2
2	Multiple pregnancy failures:an immunological paradigm显示文摘	Matthiesen L Kalkunte S Sharma S	2012	American Journal of Reproductive Immunology2012，67，：	1
3	The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies 显示文摘	Tewari N Kalkunte S Murray DW	2009	J Biol Chem2009，284，15：	1
4	Inhibition of angiogenesis by vitamin D-binding protein: characterization of anti-endothelial activity of DBP-maf 显示文摘	Kalkunte S Brard L Granai C O	2005	Angiogenesis2005，8，：	1
5	Vascular endothelial growth factor C facilitates immune tolerance and endo- vascular activity of human uterine NK ceils at the maternal - fetal interface显示文摘	KALKUNTE S S MSELLE T F NORRIS W E	2009	J Immunol2009，182，7：	1
6	Uterine Regulatory T eells,IL-10 and hypertension显示文摘	Nevers T Kalkunte S Sharma S	2011	Am J Reprod Immunol2011，66，1：	1
7	The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies显示文摘	Tewari N Kalkunte S Murray D W	2009	J Biol Chem2009，284，15：	1
8	Degradation of NF-KB, p53 and other regulatory redox- sensitive proteins by thiolconjugating and nitrosylating drugs in human tumor cells 显示文摘	AMEYA PARANJPE KALKUNTE S SRIVENUGOPAL	2013	Carcinogenesis2013，34，5：	1
9	The water channel aqua- porin 1 is a novel molecular target of polyehlorinated biphenyls forin utero anomalies显示文摘	Tewari N Kalkunte S Murray DW	2009	J Biol Chem2009，284，15：	1
10	Inhibition of angiogenesis by vitamin D-binding protein:characterization of anti-endothelial activity of DBP-maf显示文摘	Kalkunte S Brard L Granai CO		0，，04：	1
11	In vitro and in vivo evidence for lack of endovascular remodeling by third trimester trophoblasts显示文摘	Kalkunte S Lai Z Tewari N	2008	Placenta2008，29，10：	1
12	Sera from Preeclampsia Patients Elicit Symptoms of Human Disease in Mice and Pro- vide a Basis for an in Vitro Predictive Assay显示文摘	Kalkunte S Boij R Norris W	2010	Am J Pathol2010，177，5：	1
13	Evolution of non - cyto-toxic uterine natural killer cells显示文摘	Kalkunte S Chichester CO Gotsch F	2008	Am J Reprod Immunol2008，59，5：	1
14	Vascular IL-10:A protective role in preeclampsia显示文摘	Kalkunte S Nevers T Norris WE	2011	J Reprod Immunol2011，88，2：	1
15	Vascular IL-10: a protec- tive role in preeclampsia 显示文摘	Kalkunte S Nevers T Norris W E	2011	J Reprod Immunol2011，88，2：	1
16	Evolution of non-cytotoxic uterine natural killer cells显示文摘	Kalkunte S Chichester CO Gotsch F	2008	Am J Reprod Immunol2008，59，5：	1
17	A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice 显示文摘	Lai Z B Kalkunte S Sharma S	2011	Hypertension2011，57，：	1
18	Multiple pregnancy failures: an immunological paradigm 显示文摘	Matthiesen L Kalkunte S Sharma S	2012	Am J Reprod Immunol2012，67，4：	1
19	The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies显示文摘	Tewari N Kalkunte S Murray DW	2009	J Biol Chem2009，284，15：	1
20	Uterine regulatory T cells, lL-10 and hypertension显示文摘	NEVERS T KALKUNTE S SHARMA S	2011	Am J Reprod Immunol2011，66，：	1

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