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465篇 您的检索式:作者名="K Kuwano"
    题名 作者 年代 出处 被引量
1治疗肺动脉高压药物赛乐西帕显示文摘1研制背景花生四烯酸(AA)代谢产物中的一个重要成分是前列环素(1,PGl2),主要在血管内皮细胞中生成。PGI:具有多种生理功能,可强效地舒张血管,抑制血小板聚集,还抑制血管平滑肌细胞分化、增殖和迁移。PGl2的这些功能是通过与血管平滑肌细胞、血小板或其他细胞膜上的PGl2受体结合而产生的。PGl2途径的下调可引起一些血管性疾病,例如肺动脉高压。郭宗儒 asaki t kuwano k morrison k 2018药学学报2018,53,12:3
2Analysis on permanent deformation of embankments caused by earthquakes 显示文摘Kuwano J Ishihara K Haya H 1991Soils and Foundations1991,31,3:1
3Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis显示文摘Kuwano K Hagimoto N Kawasaki M 1999J Clin Invest1999,104,1:1
4Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis显示文摘Maeyama T Kuwano K Kawasaki M 2001Eur Respir2001,17,2:1
5Expression of apoptosis-regulatory genes in epithelial cells in pulmonary fibrosis in mice显示文摘Kuwano K Hagimoto N Tanaka T 2000J Pathology2000,190,2:1
6Molecular mechanisms of pulmomary fibrosis and current treatment 显示文摘Kuwano K Hagimoto N Hara N 2001Curr Mol Med2001,1,:1
7Upregulation of Fas-sig- nailing molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis 显示文摘Maeyama T Kuwano K kawasaki M et ai 2001Eur Respir J2001,17,2:1
8Expression of apoptosis regulatory genes in epithelial cells in pulmonary fibrosis in mice显示文摘Kuwano K Hagimoto N Tanaka T 2000J Pathol2000,190,2:1
9Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor显示文摘Kuwano K Kunitake R Maeyama T 2001Am Physiol Lung Cell Mol Physiol2001,280,2:1
10Protection from lethal apoptosis in lipopolysaccharide - induced acute lung injury in mice by a caspase inhibitor显示文摘Kawasaki M Kuwano K Hagimoto N 2000Am J Pathol2000,157,2:1
11Soluble forms of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia 显示文摘Kuwano K Kawaski M Maeyama T 2000Chest2000,118,2:1
12Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen显示文摘Hagimoto N Kuwano K Miyazaki H 1997Am J Respir Cell Mol Bio1997,17,3:1
13Induction of interleukin-8 secretion and apoptosis in bronchiolar epithelial cells by Fas ligation显示文摘Hagimoto N Kuwano K Kawasaki M 1999Am J Respir Cell Mol Biol1999,21,3:1
14Apoptosis in the course of granulomatous inflammation in pulmonary sarcoidosis 显示文摘R Kunitake K Kuwano H Miyazaki 1999Eur Respir J1999,13,6:1
15Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis 显示文摘Inoshima Kuwano K Hamada N Yoshimi M Maeyama T Hagimoto N 2004Am J Physiol2004,286,2:1
16The utility of p53immunostaining of transbronchial biopsy specimens of lung cancer:p53 overexpression predicts poor prognosis and chemoresistance in advanced non small cell lung cancer显示文摘Kawasaki M Nakanishi Y Kuwano K 1997Clin Cancer Res1997,3,7:1
17Comparison between the shape of reseeted femoral sections and i~moral prostheses used in total knee arthroplasty in Japanese patients: simulation using three-dimensional computed tomography显示文摘Urabe K Miura H Kuwano T 2003J Knee Surg2003,16,:1
18Proteins of 30 and 36 kilodahons, membrane constituents of the Staphylococcus aureus L form, induce production of tumor necrosis factor alpha and activate the human immunodeficiency virus type 1 long terminal repeat显示文摘Akashi A Ono S Kuwano K 1996Infect Immun1996,64,8:1
19Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases 显示文摘Kuwano K Maeyama T Inoshima I 2002Respirology2002,7,1:1
20A long-acting and highly selective prostacyclin receptor agonist prodrug, 2- {4- butoxy}- N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-butoxy} acetic acid (MRE-269), on rat pulmonary artery 显示文摘Kuwano K Hashino A Noda K 2008J Pharmacol Exp Ther2008,326,3:1
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