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| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 3 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 4 | miR-21 and its target gene CCL20 are both highly overexpressed in themicroenvironment of colorectal tumors: Significance of their regulation显示文摘 | Benjamin Vicinus Claudia Rubie Nathalie Stegmaier Vilma Frick Kathrin K?lsch Anne Kauffels Pirus Ghadjar Mathias Wagner Matthias Glanemann | 2013 | Oncology Reports2013，，3： | 2 |
| 5 | Impaired chronotropic response to beta-stimulation in chronic coronary artery disease显示文摘 | Frick M H Huttunen J K Harkonen M | 1973 | The American Journal of Medicine1973，55，3： | 1 |
| 6 | Improvement of the anodic bioelectrocatalytic activity of mixed culture biofilms by a simple consecutive electrochemical selection procedure显示文摘 | LIU Y HARNISCH F FRICKE K SIETMANN R SCHRODER U | 2008 | Biosens Bioeletron2008，24，4： | 1 |
| 7 | Variation of frequency of the erythrocyte flickering caused by age,osmolarity,temperature and pathological changes显示文摘 | K Fricke E Sackmann | 1984 | Biochimica et Biophysia Acta1984，803，： | 1 |
| 8 | Integrated Microwave Power Sensor显示文摘 | Krozer V Fricke K Klingbeil H | 1995 | IEEE Electron Device Letters1995，31，25： | 1 |
| 9 | Thermal processing of polycrystalline Ni-Ti shape memory alloys 显示文摘 | FRICK C P ORTEGA A M TYBER J MAKSOUND A E M MAIER H J LIU Y N GALL K | 2005 | Materials Science and Engineering A2005，405，12： | 1 |
| 10 | Coassembly of flotillins induces formation of membrane microdomains,mem brane curvature, and vesicle budding显示文摘 | FRICK M BRIGHT N A RIENTO K | 2007 | Curr Biol2007，17，13： | 1 |
| 11 | Aspirin downregulates homocysteine formation in stimulated human perip- heral blood mononuclear cells 显示文摘 | SCHROECKSNADEL K FRICK B WINKLER C | 2005 | Scand J Immunol2005，62，2： | 1 |
| 12 | In- creased intrapancreatic trypsinogen activation in ischemia-in- duced experimental pancreatitis 显示文摘 | Mithofer K Fernandez-del Castillo C Frick TW | 1995 | Ann Surg1995，22，40： | 1 |
| 13 | Molecular mechanisms of primary hypercalciuria显示文摘 | Frick K K Bushinsky D A | 2003 | J Am Soc Nephrol2003，14，4： | 1 |
| 14 | Acute hy- percalcemia causes acute panereatitis and cctoplc trypslnogen acti- vation in the rat显示文摘 | Mithofer K Fernandez-Del Castillo C Frick TW | 1995 | Gastroenterology1995，109，1： | 1 |
| 15 | Pharmacologi- cal modulation of cortical excitability shifts induced by tran- scranial direct current stimulation in humans显示文摘 | Nitsche MA Fricke K Henschke U | 2003 | J Physiol2003，553，1： | 1 |
| 16 | Age - related spatial refernce and working memory deficits assessed in the water maze显示文摘 | Frick K M Baxter M G Markowaska A L | 1995 | Neubiology of Aging1995，16，2： | 1 |
| 17 | Determining emergence of the cherry fruit fly with ammonium carbonate bait traps显示文摘 | Frick K E | 1952 | J Econ Entomol1952，45，： | 1 |
| 18 | Acute hypercalcemia causes acute pancreatitis and ec- topic trypsinogen activation in the rat显示文摘 | Mith6fer K Fem6ndez-del Castillo C Frick TW | 1995 | Gastroenterology1995，109，1： | 1 |
| 19 | D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats显示文摘 | BAXTER M G LANTHORN T H FRICK K M | 1994 | Neurobiol Aging1994，15，2： | 1 |
| 20 | Summary of a large and small scale unreinforced masonry infill test program 显示文摘 | Henderson R C Fricke K E Jones W D | 2003 | Journal of Structural Engineering2003，129，12： | 1 |
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