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| 1 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 2 | Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report of three cases显示文摘Castleman 疾病(CD ) 是有未知病原学的不平常的非同种细胞的 lymphoproliferative 混乱。没有标准治疗为 relapsed/refractory CD 病人被推荐,因此要求新奇试验性的途径的开发。我们有 multicentric CD (MCD ) 的三个成年病人的队被对待与对传统的化疗包含 lenalidomide 政体倔强(1025 mg lenalidomide perorally 在天管理了 121 在 28 天的周期) 作为第二 -- 到第四线的治疗。部分宽恕在第一个血浆房间 CD 病人被完成, relapsed 在自体同源的造血的干细胞移植以后的七个月然后没能对化疗的四个周期作出回应。organomegaly,部分宽恕与 CD 和 polyneuropathy 在第二个病人被获得 endocrinopathy, monoclonal gammopathy,和皮肤变化症候群。第三个案例与血小板计数的肋膜的流出和腹水和正规化的完全的消失显示出完全的宽恕。得出结论,令人鼓舞的临床的回答与基于 lenalidomide 的政体在三个病人的队被完成,不过,长期的功效尚待被遵守。我们在对待 MCD 建议这药的治疗学的潜力的进一步的调查。 | Xinping Zhou Juying Wei Yinjun Lou Gaixiang Xu Min Yang Hui Liu Liping Mao Hongyan Tong Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 6 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | Downregulation of microRNA‐15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2‐induced Globo H expression显示文摘 | Chen‐Shiou Wu Chia‐Jui Yen Ruey‐Hwang Chou Jia‐Ni Chen Wei‐Chien Huang Chung‐Yi Wu Yung‐Luen Yu | 2014 | Int J Cancer2014，，7： | 3 |
| 5 | Somatic Mutations Confer Severe Peripheral Neuropathy in POEMS Syndrome-Associated Multicentric Castleman Disease显示文摘Dear Editor,POEMS-associated multicentric Castleman disease(POEMS-MCD)is a subtype of MCD that presents POEMS symptoms(polyneuropathy,organomegaly,endocrinopathy,M protein,and skin changes)as well as the manifestations of MCD.Among these symptoms,polyneuropathy is a critical feature.However,its mechanism remains poorly understood.The present study presents a case of severe peripheral neuropathy in a POEMSMCD patient.Whole-exome sequencing(WES),threedimensional modeling,and protein stability analysis demonstrated that the mutation V49G in PDLIM5 resulted in instability of the protein,which may play a key role in the pathogenesis of peripheral neuropathy in POEMSMCD. | Qingqing Lin Juying Wei Jiejing Qian Liangshun You Wenbin Qian | 2020 | Neuroscience Bulletin2020，36，6： | 3 |
| 6 | Diagnosis and management of acquired thrombotic thrombocy- topenic purpura in southeast China: a single center experience of 60 cases显示文摘 | Xinping Zhou XingnongYe Yanling Ren Chen Mei Liya Ma Jiansong Huang Weilai Xu Juying Wei Li Ye Wenyuan Mai Wenbin Qian Haitao Meng Jie Jin Hongyan Tong | 2016 | Frontiers of Medicine2016，10，4： | 2 |
| 7 | Global and local co-ordinates in digital image correlation 显示文摘 | Sun Wei Quan Chenggen Tay Cho Jui | 2007 | Applied Optics2007，46，7： | 1 |
| 8 | A New Compact LTCC Bandpass Filter Using Negative Coupling 显示文摘 | Wei Shin Tung Yi Chyun Chiang Jui Ching Cheng | 2005 | IEEE Microwave and Wireless Components Letters2005，15，10： | 1 |
| 9 | Preparation and Properties of Poly(vinyl alcohol)-clay Nanocomposite Materi-als显示文摘 | Yuan H Y Ching Y L Jui M Y Wei H L | 2003 | Polymer2003，44，： | 1 |
| 10 | Adaptive chattering free variable structure control for a class of chaotic systems with unknown bounded uncertain- ties显示文摘 | YAN Jun Juh CHANG Wei Der LIN Jui Sheng | 2005 | Physics Letters A2005，335，4： | 1 |
| 11 | Influential factors and relational structure of Internet banner advertising in the tourism industry 显示文摘 | Shwu - Ing Wu Pao - Lien Wei and Jui - Ho Chen | 2007 | Tourism Management2007，28，2： | 1 |
| 12 | Influential Factors and Relational Structure of Interuet Banner Advertising in The tourism Industry 显示文摘 | Shwu - Ing Wu Pao - Lien Wei Jui - Ho Chen | 2008 | Tourism Management2008，29，1： | 1 |
| 13 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
| 14 | Downregulation of microRNA‐15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2‐induced Globo H expression显示文摘 | Chen‐Shiou Wu Chia‐Jui Yen Ruey‐Hwang Chou Jia‐Ni Chen Wei‐Chien Huang Chung‐Yi Wu Yung‐Luen Yu | 2014 | Int. J. Cancer2014，，： | 1 |
| 15 | Discovery of novel src homology region 2 domain‐containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma显示文摘 | Wei‐Tien Tai Chung‐Wai Shiau Pei‐Jer Chen Pei‐Yi Chu Hsiang‐Po Huang Chun‐Yu Liu Jui‐Wen Huang Kuen‐Feng Chen | 2014 | Hepatology2014，，1： | 1 |
| 16 | Economic design of variable sampling intervals EWMA charts with sampling at fixed times using genetic algorithms显示文摘 | Chao Y C Jui C C Wei T L | 2008 | Expert Systems with Applications2008，34，1： | 1 |
| 17 | Passive protection effect of chicken egg yolk immunoglobulins on enterovirus 71 infected mice显示文摘 | Jenn - Fa Liou Chih - Wei Chang Jui - jane Tailiu | 2010 | Vaccine2010，28，： | 1 |
| 18 | Enhancement of physical properties of electroactive polyimide nanocomposites by addition of graphene nanosheets显示文摘 | Kung‐Chin Chang Hsin‐I Lu Mei‐Chun Lai Chien‐Hua Hsu You‐Rong Hsiao Kuan‐Yeh Huang Tsao‐Li Chuang Jui‐Ming Yeh Wei‐Ren Liu | 2014 | Polym. Int2014，，6： | 1 |
| 19 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
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