|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 2 | Molecular cloning,sequencing,and expression profiles of heat shock protein 90 (HSP90) in Hyriopsis cumingii exposed to different stressors:Temperature,cadmium and Aeromonas hydrophila显示文摘Heat shock protein 90(HSP90)represents a suite of highly conserved and multi-functional molecular chaperone proteins that play an important role in cellular stress responses.In order to better understand the expression of HSP90 in mollusks,a full-length complementary DNA(cDNA)of HSP90(HcHSP90)was identified in Hyriopsis cumingii.HcHSP90 cDNA was 2659 bp in length,consisting of 30 and 50-untranslated regions and an open reading frame of 2187 bp,that encoded a 728 amino acid protein.Homology analyses showed that the HcHSP90 protein was highly conserved and had 5 well-conserved family signatures of HSP90 proteins.HcHSP90 mRNA expressed in various tissues of H.cumingii.The expression level of HcHSP90 was the highest in the digestive gland.In all tissues,with the exception of the digestive gland where it was down-regulated,HcHSP90 mRNA expression was significantly induced by temperature treatments(0,5,25,and 35℃)relative to the control(15℃).Exposure of H.cumingii to different concentrations of cadmium(50,100,and 200 mg/L),up-regulated HcHSP90 mRNA in the haemolymph and gill but without an obvious dose-dependent response.When H.cumingii were infected with Aeromonas hydrophila,HcHSP90 mRNA expression in the haemolymph was up-regulated and peaked 36 h post-infection,while in the gills it was significantly up-regulated 3 h post-infection in the gills,then remained constant until returning to pre-challenge expression levels at 36 h post-infection.The results show that HcHSP90 expression can be significantly regulated by changes in temperature,cadmium exposure and bacterial infection.We deduced that HSP90 may play an important role in helping H.cumingii to cope with environmental stress. | Qin Wang Junnan Wang Guiling Wang Congdi Wu Jiale Li | 2017 | Aquaculture and Fisheries2017，2，2： | 2 |
| 3 | Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress显示文摘(Rce1 ) 地岬和 a-factor-converting 酶 1 位于 endoplasmic 蜂窝胃(嗯) 并且被认为为绝大多数 CAAX 蛋白质处理的 endoproteolytic 负责。Endoplasmic 蜂窝胃应力(ERS ) 在肾的房间癌(RCC ) 起一个重要作用;然而,在 RCC 的 Rce1 的表示和角色广泛地没被学习。我们试图在 RCC 786-O 房间在嗯导致 apoptosis 在 RCC 纸巾和它的分子的机制调查 Rce1 的表示。我们首先使用了检测在肾的癌纸巾和 paracancerous 纸巾的 Rce1 表示的西方的弄污,量的反向的 transcriptase 聚合酶链反应,和 immunohistochemistry。Rce1 表示是在 RCC 的 upregulated,这被发现纸巾,和它的积极表示水平强烈与 clinicopathologic 特征被联系。下次,我们在人的胚胎的肾房间线 HEK293 和人的肾的癌房间线 786-O 检测了 Rce1 的表示, ACHN,和 A498。Rce1 的更高的表示在人的肾的癌房间线被发现,特别在 786-O 房间。在 786-O 房间的 Rce1 击倒增加的 apoptosis | Jianjun Li Delin Wang Junnan Liu Yunlang Qin Liangliang Huang Qiangfeng Zeng Maolin Xiao Jie Hu Qixin Yang Jiang He Li Mai Ying Li Wujiang Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 4 | Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways显示文摘Glucagon-like peptide-1(GLP-1),a novel type of glucose-lowering agent,has been reported to exert cardioprotective effects.However,the cardioprotective mechanism of GLP-1 on spontaneous hypertension-induced cardiac hypertrophy has not been fully elucidated.In this study,we revealed that liraglutide or alogliptin treatment ameliorated spontaneous hypertension-induced cardiac hypertrophy,as evidenced by decreased levels of cardiac hypertrophic markers(atrial natriuretic peptide,brain natriuretic peptide,andβ-myosin heavy chain),as well as systolic blood pressure,diastolic blood pressure,mean arterial pressure,and histological changes.Both drugs significantly reduced the levels of angiotensin II(AngII)and AngII type 1 receptor(AT1R)and upregulated the levels of AngII type 2 receptor(AT2R)and angiotensin-converting enzyme 2(ACE2),as indicated by a reduced AT1R/AT2R ratio.Simultaneously,treatment with liraglutide or alogliptin significantly increased GLP-1 receptor expression and adenosine monophosphate-activated protein kinase(AMPK)phosphorylation and downregulated the phosphorylation of mammalian target of rapamycin(mTOR),p70 ribosomal S6 protein kinase,and eukaryotic translation initiation factor 4E binding protein 1 in spontaneous hypertension rats.Furthermore,our data demonstrated that the AMPK inhibitor compound C or mTOR activator MHY1485 inhibited the anti-hypertrophic effect of GLP-1.In summary,our study suggests that liraglutide or alogliptin protects the heart against cardiac hypertrophy by regulating the expression of AngII/AT1R/ACE2 and activating the AMPK/mTOR pathway,and GLP-1 agonist can be used in the treatment of patients with cardiac hypertrophy. | Jing Wang Shaohua Fan Qianfeng Xiong Yu Niu Xin Zhang Junnan Qin Yawei Shi Lihui Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 1 |
| 5 | Controllable synthesis of hollow mesoporous silica spheres and application as support of nano-gold显示文摘 | Weihua Ma Tao Wang Junnan Shangguan Wei Jiang Qin Zhong | 2014 | Journal of Solid State Chemistry2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员