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| 1 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 2 | Impacts of thermodynamic processes over the Tibetan Plateau on the Northern Hemispheric climate显示文摘We here report our recent research results on the climatic features of Tibetan thermodynamic functions and their impacts on the regional climates of the Northern Hemisphere. The results show that the thermodynamic processes over the Tibetan Plateau not only strongly influence the Asian monsoon and precipitation, but also modulate the atmospheric circulation and climate over North America and Europe through stimulating the large-scale teleconnections such as the Asian-Pacific oscillation and affect the atmospheric circulation over the southern Indian Ocean. The Tibetan climate may be affected by sea surface temperatures over the tropical Pacific. On the other hand, the Tibetan climate also affects the atmosphere-ocean interactions in the tropics and mid-latitudes of the Pacific by the atmospheric circulation over the North Pacific. In spring and summer, the thermodynamic anomalies on the plateau affect the subtropical high pressure, the Hadley circulation, and the intertropical convergence zone over the Pacific, and then modulate the development of the El Ni-o/Southern Oscillation (ENSO). It is necessary to study the forecasting methods for the development of ENSO from the Tibetan climate anomaly. This result also embodies the essence of interactions among land, atmosphere, and ocean over the Northern Hemisphere. Since the previous studies focused on impacts of the plateau on climates in the Asian monsoon regions, it is essential to pay more attention to studying the roles of the plateau in the Northern Hemispheric and even global climates. | ZHOU XiuJi ZHAO Ping CHEN JunMing CHEN LongXun LI WeiLiang | 2009 | Science China Earth Sciences2009，52，11： | 42 |
| 3 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 4 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 5 | Single Current Feedback Control Strategy for Grid-connected Inverters With LCL Filters显示文摘LCL滤波器广泛应用于并网逆变器系统中,其对高次谐波具有良好的衰减作用;但LCL滤波器为低阻尼三阶系统,容易发生谐振。传统的有源阻尼方法,通过对电容电流进行采样并反馈,能够抑制系统振荡,但增加了传感器数量。提出一种单电流反馈控制策略,其采用入网电流两次微分的反馈方法,增加了系统阻尼,从而有效地抑制LCL滤波器的谐振尖峰,保证系统的稳定性;同时其对系统参数不敏感,并且不增加额外的传感器,是一种低成本高可靠性的控制策略。文中推导该控制策略下的系统传递函数,并分析系统的稳定性。最后,通过仿真和实验,验证提出的控制策略的可行性与有效性。 | CHEN Dong ZHANG Junming QIAN Zhaoming | 2013 | 中国电机工程学报2013，33，9： | 33 |
| 6 | Metallogenesis related to Mesozoic Granitoids in the Nanling Range, South China and Their Geodynamic Settings显示文摘Affected by the compressive stress from the South-Central (Indo-China) Peninsula, the Indosinianorogenesis, characterized by collision, thrust and uplifting, took place inside the South China Plate during 250?230 Ma.The ages of the Indosinian granitoids in the Nanling Range and vicinity areas are mostly 240?205 Ma, indicating that theywere emplaced in both late collision and post-collision geodynamic environments. No important granite-relatedmetallogenesis occurred in this duration. A post-orogenic setting started at the beginning of the Yanshanian Period, whichcontrolled large-scale granitic magmatism and related metallogenesis. This paper makes the first attempt to divide theYanshanian Period into three sub-periods, i.e. the early, middle and late Yanshanian Periods, based mainly on the featuresof magmatism, especially granitoids and related metallogenesis and their geodynamic environments. The magmaticassociation of the Early Yanshanian (about 185?170 Ma) comprises four categories of magmatism, i.e. basalt, bimodalvolcanics, A-type granite and intraplate high-K calc-alkaline (HKCA) magmatism, which indicates an extension-thinningof lithosphere and upwelling of mantle material to a relative small and local extent. Pb-Zn, Cu and Au mineralizationsassociated with HKCA magmatism represents the first high tide of Mesozoic metallogenesis in the Nanling Range area.During the middle Yanshanian, the lithosphere was subjected to more extensive and intensive extending and thinning, andhence mantle upwelling and basaltic magma underplating caused a great amount of crust remelting granitoids. This periodcan be further divided into two stages. The first stage (170?150 Ma) is represented by large-scale emplacement of crustremelting granites with local tungsten mineralization at its end. The second stage (150?140 Ma) is the most important timeof large-scale mineralizations of non-ferrous and rare metals, e.g. W, Sn, Nb-Ta, Bi, Mo, Be, in the Nanling Range area.The late Yanshanian (140?65 Ma) was generally characterized by full extension and breakup of the lithosphere of SouthChina. However, owing to the influence of the Pacific Plate movement, the eastern part of South China was predominatedby subduction-related compression, which resulted in magmatism of calc-alkaline and shoshonite series and relatedmetallogeneses of Au, Ag, Pb-Zn, Cu and (Mo, Sn), followed by extension in its late stage. In the Nanling Range area, thelate Yanshanian magmatism was represented by granitic volcanic-intrusive complexes and mafic dikes, which aregenetically related to volcanic-type uranium and porphyry tin deposits, and the mobilization-mineralization of uraniumfrom pre-existing Indosinian granites. | HUA Renmin CHEN Peirong ZHANG Wenlan YAO Junming LIN Jinfu ZHANG Zhanshi GU Shengyan LIU Xiaodong QI Huawen | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 22 |
| 7 | Effects of dietary arginine levels on growth performance,body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco)显示文摘This experiment was conducted to investigate the effects of dietary arginine levels on growth performance, body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco). Five isonitrogenous and isolipidic diets(42%protein and 9% lipid) were formulated to contain graded levels of arginine(2.44%, 2.64%, 2.81%, 3.01% and3.23% of diet), by supplementing L-Arginine HCI. Seven hundred juvenile yellow catfish with an initial average body weight of 1.13 ± 0.02 g were randomly divided into 5 groups with 4 replicates of 35 fish each and each group was fed one of the diets. After 56 d feeding, fish were exposed to 100 mg/L of ammonia-nitrogen for 72 h. The results showed that weight gain(WG) and specific growth rate(SGR) in2.64% and 2.81% groups were significantly higher than those in 3.23% group(P < 0.05). The feed conversation ratio(FCR) in 2,64%, 2,81% and 3.01% groups was significantly decreased when compared with3,23% group. The protein efficiency ratio(PER) in 2.64% group was significantly higher than that in 2.44%and 3.23% groups(P < 0.05). The condition factor(CF) of fish was significantly higher in 2.81% group than that in 2,44% group(P < 0.05). Dietary arginine levels had no significant effect on hepatosomatic index(HSI), viscerosomatic index(VSI), and whole-body dry matter, crude protein, crude lipid, ash contents, as well as serum total protein(TP), triglyceride(TG), glucose(GLU), urea nitrogen(UN) contents and aspartate aminotransferase(AST), alanine aminotransferase(ALT) activities(P> 0.05). After the fish were challenged to ammonia-nitrogen for 72 h, their cumulative mortality rate in 2.81% group was significantly lower than that in 2.44% group(P < 0.05). The results suggested that dietary arginine level at 2.81%could optimize anti-ammonia-nitrogen stress ability of juvenile yellow catfish and a level of 3.23%arginine seemed to depress the growth performance of fish and decreased their tolerance to the ammonia-nitrogen stress under current study. A quadratic regression analysis based on WG indicated that the optimal dietary arginine requirement of juvenile yellow catfish was estimated to be 2.74% of the diet(6.45% of dietary protein) under current culture conditions. | Qiming Chen Hongxia Zhao Yanhua Huang Junming Cao Guoxia Wang Yuping Sun Yongjuan Li | 2016 | Animal Nutrition2016，，3： | 19 |
| 8 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 9 | Photonic integrated technology for multi-wavelength laser emission显示文摘We summarized the design, fabrication challenges and important technologies for multi-wavelength laser transmitting photonic integration. Technologies discussed include multi-wavelength laser arrays, monolithic integration and modularizing coupling and packaging. Fabrication technique requirements have significantly declined with the rise of reconstruction-equivalent-chirp and second nanoimprint mask technologies. The monolithic integration problem between active and passive waveguides can be overcome with Butt-joint and InP array waveguide grating technologies. The dynamic characteristics of multi-factors will be simultaneously measured with multi-port analyzing modules. The performance of photonic integration chips is significantly improved with the autoecious factors compensation packaging technique. | CHEN XiangFei LIU Wen AN JunMing LIU Yu XU Kun WANG Xin LIU JianGuo JI YueFeng ZHU NingHua | 2011 | Chinese Science Bulletin2011，56，28： | 9 |
| 10 | Global climate effects of summer Tibetan Plateau显示文摘Because the Tibetan Plateau (TP)has the highest elevation in the world and is a key area affecting the Asian extreme weather and climate events,studies on the Tibetan Plateau meteorology have been highly concerned by the international scientific community.In the late 1970s.Ye and Gao [1]reveled the climatic characteristics of the TP heating and its connection with global and regional atmospheric circulations.With the seasonal evolution from winter to summer,strong surface sensible heat regulates the timing of the establishment of the Asian summer monsoon [2].However,Boos and Kuang [3]addressed that the large-scale South Asian summer monsoon is unaffected by removal of the plateau,provided that the narrow orography of the Himalayas and adjacent mountain ranges is preserved,and revealed the domi- nance of the uplift of the Himalayas in the formation of the present South Asian summer monsoon.Then,does this indicate a weak effect of the summer TP thermal forcing on the variability of the present South Asian monsoon and larger-scale climates?Some dis- cussions have been also stimulated in Science [4]. | Ping Zhao Xiuji Zhou Junming Chen Ge Liu Sulan Nan | 2019 | Science Bulletin2019，64，1： | 7 |
| 11 | Curative effect of Xuebijing injection on severe pulmonary contusion显示文摘OBJECTIVE: To investigate the curative effects of Xuebijing(XBJ) injection, a Chinese patent medicine, on severe pulmonary contusion(PC). METHODS: Sixty-three patients with PC were randomized to conventional therapy plus XBJ injection(n=33) or conventional therapy alone(n=30). Between groups differences in corticosteroid treatment, immune regulation therapy, hemofiltration, infusion volume, transfusion volume and antibiotic period were measured, as were intensive care unit (ICU)-free time, ventilation time, 28-day mortality rate and incidence of ventilation-associated pneumonia(VAP). Serum concentrations of procalcitonin(PCT), tumor necrosis factor-α(TNF-α), interleukin(IL)-6, and IL-10, white blood cell(WBC) counts and percentages of human leukocyte antigen DR/ CD14+(HLA-DR/CD14+) peripheral blood mononuclear cells were compared. Markers of ventilation were determined by blood gas analysis and ventilator parameters. RESULTS: WBC counts and serum concentrations of PCT, TNF-α, IL-6 and IL-10 were reduced significantly more quickly, and CD14+ percentage was increased significantly earlier, in the XBJ group than in the control group(P<0.05 each).The level of ventilation and oxygenation index were ameliorated earlier in the XBJ than in the control group(P< 0.05). XBJ treatment significantly reduced ICU-stay time, ventilation time and incidence of VAP(P<0.05 each), but had no effect on 28-day mortality rate(P>0.05). CONCLUSION: XBJ treatment can shorten ICU-free and ventilation times and reduce the incidence of VAP, improving outcomes in patients with severe PC. XBJ may act by regulating inflammation and immunity, alleviating systemic inflammatory response syndrome induced by trauma. | Yi Chen Huasheng Tong Wang Zhang Xingqin Zhang Zhigguo Pan Junming Qiu Ruihuan Pan Lei Su | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 6 |
| 12 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 13 | Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages显示文摘Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic signaling motifs,are highly expressed by myeloid cells.Due to the potential redundancy,whether these two receptors regulate macrophage function remains largely unknown.Here,we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation.To overcome the redundancy,we generated mice that simultaneously lacked SLAMF8 and SLAMF9 using CRISPR-Cas9 technology.Although macrophage differentiation was not altered by the combined deficiency of SLAMF8 and SLAMF9,the loss of these two receptors significantly protected against lipopolysaccharide(LPS)-induced liver injury.SLAMF8 and SLAMF9 double-deficient mice had a prolonged survival rate and less infiltration of inflammatory cells.The depletion of macrophages using clodronate liposomes abolished the effects of SLAMF8 and SLAMF9 deficiencies on LPS-induced liver injury,which demonstrates that these receptors are required for macrophage activation following LPS challenge.Moreover,the deficiency of SLAMF8 and SLAMF9 suppressed the secretion of inflammatory cytokines by downregulating the expression of Toll-like receptor-4(TLR4),a receptor that specifically binds LPS,which led to decreased mitogen-activated protein kinases(MAPK)signaling activation.Notably,combined injections of truncated extracellular SLAMF8 and SLAMF9 proteins significantly alleviated LPS-induced liver injury.Thus,our findings provide insights into the role of SLAMF8 and SLAMF9 in endotoxin-induced liver injury and suggest that SLAMF8 and SLAMF9 are potential therapeutic targets for acute hepatic injury. | Xiaokang Zeng Guangao Liu Wanwen Peng Junming He Chenxu Cai Wei Xiong Shasha Chen Meixiang Yang Zhongjun Dong | 2020 | Cellular & Molecular Immunology2020，17，2： | 5 |
| 14 | Development of an invasive brain machine interface with a monkey model显示文摘Brain-machine interfaces (BMIs) translate neural activities of the brain into specific instructions that can be carried out by external devices. BMIs have the potential to restore or augment motor functions of paralyzed patients suffering from spinal cord damage. The neural activities have been used to predict the 2D or 3D movement trajectory of monkey's arm or hand in many studies. However, there are few studies on decoding the wrist movement from neural activities in center-out paradigm. The present study developed an invasive BMI system with a monkey model using a 10×10-microelectrode array in the primary motor cortex. The monkey was trained to perform a two-dimensional forelimb wrist movement paradigm where neural activities and movement signals were simultaneous recorded. Results showed that neuronal firing rates highly correlated with forelimb wrist movement; > 70% (105/149) neurons exhibited specific firing changes during movement and > 36% (54/149) neurons were used to discriminate directional pairs. The neuronal firing rates were also used to predict the wrist moving directions and continuous trajectories of the forelimb wrist. The four directions could be classified with 96% accuracy using a support vector machine, and the correlation coefficients of trajectory prediction using a general regression neural network were above 0.8 for both horizontal and vertical directions. Results showed that this BMI system could predict monkey wrist movements in high accuracy through the use of neuronal firing information. | ZHANG QiaoSheng ZHANG ShaoMin HAO YaoYao ZHANG HuaiJian ZHU JunMing ZHAO Ting ZHANG JianMin WANG YiWen ZHENG XiaoXiang CHEN WeiDong | 2012 | Chinese Science Bulletin2012，57，16： | 4 |
| 15 | The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment显示文摘The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian 'atmospheric water tower' and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation of sensible heat flux can be reduced via modifying the heat transfer parameterization over the TP, and considering climatic signals in some key areas of the TP can improve the skill for rainfall forecast in the central and eastern parts of China. Furthermore, the TIPEX-Ⅲ has been promoting the technology in processing surface observations, soundings, and radar observations, improving the quality of satellite retrieved soil moisture and atmospheric water vapor content products as well as high-resolution gauge–radar–satellite merged rainfall products, and facilitating the meteorological monitoring, forecasting, and data sharing operations. | Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun CHEN Yanju LIU Jian LI Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 16 | MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation显示文摘 | Ruirui Ji Yunhui Cheng Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | Circulation Research2007，，11： | 4 |
| 17 | Characterization of different-Al-content AlGaN/GaN heterostructures on sapphire显示文摘Al x Ga 1-x N/GaN high-electron-mobility transistor (HEMT) structures with Al composition ranging from x = 0.13 to 0.36 are grown on sapphire substrates by low-pressure metalorganic chemical vapor deposition (LP-MOCVD). The effects of Al content on crystal quality, surface morphology, optical and electrical characteristics of the AlGaN/GaN heterostructures have been analyzed. Although high Al-content (36%) heterostructure exhibits a distinguished photoluminescence peak related to recombination between the two-dimensional electron gas and photoexcited holes (2DEG-h), its crystal quality and rough surface morphology are poor. 2DEG mobility increases with the Al content up to 26% and then it apparently decreases for high Al-content (36%) AlGaN/GaN heterostructure. The increase of sheet carrier density with the increase of Al content has been observed. A high mobility at room temperature of 2105 cm 2 /V s with a sheet carrier density of n s = 1.10 × 10 13 cm -2 , for a 26% Al-content AlGaN/GaN heterostructure has been obtained, which is approaching state-of-the-art for HEMT grown on SiC. Sheet resistance as low as 274 Ω/□ has also been achieved. | DING GuoJian , GUO LiWei, XING ZhiGang, CHEN Yao, XU PeiQiang, JIA HaiQiang, ZHOU JunMing & CHEN Hong Beijing National Laboratory of Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 3 |
| 18 | Integration of data-intensive,machine learning and robotic experimental approaches for accelerated discovery of catalysts in renewable energy-related reactions显示文摘Technological advancements in recent decades have greatly transformed the field of material chemistry.Juxtaposing the accentuating energy demand with the pollution associated,urgent measures are required to ensure energy maximization,while reducing the extended experimental time cycle involved in energy production.In lieu of this,the prominence of catalysts in chemical reactions,particularly energy related reactions cannot be undermined,and thus it is critical to discover and design catalyst,towards the optimization of chemical processes and generation of sustainable energy.Most recently,artificial intelligence(AI)has been incorporated into several fields,particularly in advancing catalytic processes.The integration of intensive data set,machine learning models and robotics,provides a very powerful tool in modifying material synthesis and optimization by generating multifarious dataset amenable with machine learning techniques.The employment of robots automates the process of dataset and machine learning models integration in screening intermetallic surfaces of catalyst,with extreme accuracy and swiftness comparable to a number of human researchers.Although,the utilization of robots in catalyst discovery is still in its infancy,in this review we summarize current sway of artificial intelligence in catalyst discovery,briefly describe the application of databases,machine learning models and robots in this field,with emphasis on the consolidation of these monomeric units into a tripartite flow process.We point out current trends of machine learning and hybrid models of first principle calculations(DFT)for generating dataset,which is integrable into autonomous flow process of catalyst discovery.Also,we discuss catalyst discovery for renewable energy related reactions using this tripartite flow process with predetermined descriptors. | Oyawale Adetunji Moses Wei Chen Mukhtar Lawan Adam Zhuo Wang Kaili Liu Junming Shao Zhengsheng Li Wentao Li Chensu Wang Haitao Zhao Cheng Heng Pang Zongyou Yin Xuefeng Yu | 2021 | Materials Reports(Energy)2021，1，3： | 3 |
| 19 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 20 | A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation,apoptosis and M2 macrophages polarization显示文摘Glioma is a primary aggressive brain tumor with high recurrence rate.The poor efficiency of chemotherapeutic drugs crossing the blood-brain barrier(BBB) is well-known as one of the main challenges for anti-glioma therapy.Moreover,massive infiltrated tumor-associated macrophages(TAMs) in glioma further thwart the drug efficacy.Herein,a therapeutic nanosystem(SPP-ARV-825) is constructed by incorporating the BRD4-degrading proteolytic targeting chimera(PROTAC) ARV-825 into the complex micelle(SPP) composed of substance P(SP) peptide-modified poly(ethylene glycol)-poly(D,L-lactic acid)(SP-PEG-PDLL A) and methoxy poly(ethylene glycol)-poly(D,L-lac tic acid)(mPEG-PDLL A,PP),which could penetrate BBB and target brain tumor.Subsequently,released drug engenders antitumor effect via attenuating cells proliferation,inducing cells apoptosis and suppressing M2 macrophages polarization through the inhibition of IRF4 promoter transcription and phosphorylation of STAT6,STAT3 and AKT.Taken together,our work demonstrates the versatile role and therapeutic efficacy of SPP-ARV-825 micelle against glioma,which may provide a novel strategy for glioma therapy in future. | Tingting Yang Yuzhu Hu Junming Miao Jing Chen Jiagang Liu Yongzhong Cheng Xiang Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
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